In vivo comparison of bioactive glass particles in rabbits

Vogel, Martin; Voigt, Christian; Groß, Ulrich; Müller‐Mai, C. M.

doi:10.1016/s0142-9612(00)00191-5

Cited by 137 publications

(114 citation statements)

References 14 publications

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“…During surgery, it was observed that the bioglass in the particulate form facilitated its implementation, which agrees with Vogel et al (2001), who made a similar observation and reported it to be particularly useful for the treatment of bone defects. Furthermore, the great capacity of Bioglass cohesion resulted in adequate compaction of the material and consequently in bleeding reduction.…”

Section: Resultssupporting

confidence: 82%

“…Some authors have suggested that Bioglass has osteoinductive effect, namely, the capacity to induce differentiation of cells into osteoblasts (Oonish et al 1999;Xynus et al, 2001). Later, however, it was proven that it is only osteoconductive, serving as a matrix for migration and proliferation of osteoprogenitor cells (Vogel et al 2001;Carlo et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Particulate bioglass in the regeneration of alveolar bone in dogs: clinical, surgical and radiographic evaluations

Tsiomis¹,

Borges²,

Daibert³

et al. 2011

Rev. Ceres

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RESUMOAvaliação clinico-cirúrgica e radiográfica do biovidro particulado na regeneração do osso alveolar de cães A perda óssea, tanto por traumas quanto por outras afecções, gera uma necessidade cada vez maior do uso de substitutos para este tecido. Este trabalho avaliou o biovidro como substituto ósseo na regeneração do osso alveolar da mandíbula de cães, por meio de análises clínico-cirúrgica e radiográfica. Foram utilizados 28 cães adultos, separados aleatoriamente em dois grupos iguais. Em cada animal, foi criado um defeito ósseo na superfície vestibular do osso alveolar, entre as raízes do dente quarto pré-molar direito. No grupo tratado, o defeito foi imediatamente preenchido com biovidro, enquanto no controle, este permaneceu sem preenchimento. Foram realizadas avaliações clínicas diárias durante uma semana, assim como radiografias logo após a cirurgia e aos oito, 14, 21, 42, 60, 90 e 120 dias do pós-operatório. A maioria dos animais dos dois grupos não apresentou sinais de inflamação e a cicatrização da ferida cirúrgica ocorreu de forma semelhante. O exame radiográfico revelou aumento gradual da radiopacidade na região do defeito no grupo controle. No grupo tratado, observou-se inicialmente radiopacidade superior à do osso adjacente, diminuindo até os 21 dias de pós-operatório, voltando a aumentar gradativamente até os 120 dias do pós-cirúrgico, quando o defeito tornou-se imperceptível. O biovidro é integrado ao tecido ósseo, é biocompatível e diminuiu o período para a completa regeneração óssea. Bone loss, either by trauma or other diseases, generates an increasing need for substitutes of this tissue. This study evaluated Bioglass as a bone substitute in the regeneration of the alveolar bone in mandibles of dogs by clinical, surgical and radiological analysis. Twenty-eight adult dogs were randomly separated into two equal groups. In each animal, a bone defect was created on the vestibular surface of the alveolar bone between the roots of the fourth right premolar tooth. In the treated group, the defect was immediately filled with bioglass, while in the control, it remained unfilled. Clinical evaluations were performed daily for a week, as well as x-rays immediately after surgery and at 8, 14, 21, 42, 60, 90 and 120 days post-operative. Most animals in both groups showed no signs of inflammation and wound healing was similar. Radiographic examination revealed a gradual increase of radiopacity in the region of the defect in the control group. In the treated group, initial radiopacity was higher than that of adjacent bone, decreasing until 21 days after surgery. Then it gradually increased until 120 days after surgery, when the defect became undetectable. The results showed that Bioglass integrates into bone tissue, is biocompatible and reduced the period for complete bone regeneration. Palavras

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Section: Resultssupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Particulate bioglass in the regeneration of alveolar bone in dogs: clinical, surgical and radiographic evaluations

Tsiomis¹,

Borges²,

Daibert³

et al. 2011

Rev. Ceres

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show abstract

“…Bioglass Ò is a biocompatible and osteoconductive biomaterial. It bonds to bone without an intervening fibrous connective tissue interface and, due to these properties, it has been widely used for filling bone defects [169]. The primary shortcoming of Bioglass Ò is mechanical weakness and low fracture toughness due to an amorphous two-dimensional glass network.…”

Section: Polymersmentioning

confidence: 99%

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Dorozhkin¹

2009

J Mater Sci

283

146

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“…Many silicate bioactive glasses have been studied such as 45S5, 52S and 55S.The 45S5 Bioglass ® with the composition (45 % SiO 2 , 24.5 % Na 2 O, 24.5 % CaO, 6 % P 2 O 5 in weight %) has the highest solubility rate and exhibits excellent bioactivity enabling its application in bone regeneration and tissue engineering [7]. Many elements like Li, K, Mg, Sr, Zn etc., have been incorporated into different silicate glass compositions to improve dissolution, enhance the cellular response, rate of tissue regeneration and amelioration their physical properties [8,9].…”

Section: Introductionmentioning

confidence: 99%

Structure and Characterization of Some High Chemically Resistance Silicate Glasses

Abo-Mosallam¹

2016

Ceramics - Silikaty

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In vivo comparison of bioactive glass particles in rabbits

Cited by 137 publications

References 14 publications

Particulate bioglass in the regeneration of alveolar bone in dogs: clinical, surgical and radiographic evaluations

Particulate bioglass in the regeneration of alveolar bone in dogs: clinical, surgical and radiographic evaluations

Calcium orthophosphate-based biocomposites and hybrid biomaterials

Structure and Characterization of Some High Chemically Resistance Silicate Glasses

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