In vivo chronic effect of dimethoate and deltamethrin on rabbits

Abstract

The in vivo effect of dimethoate and deltamethrin on body and organ weights, serum proteins and on plasma acetylcholinesterase (AChE), aromatic esterase and ATPase were examined in growing male rabbits throughout five months period. Both compounds had no significant effect on body weight; however, adrenal, testis & pituitary weights decreased (P less than 0.01); the liver and spleen weights increased (P less than 0.01) in a dose dependent manner. Serum total proteins and globulin decreased (P less than 0.01) in a dose dependent trend, while serum albumin was not greatly affected. AChE activity was increased (P less than 0.01) after 1 month of treatment with the two doses of dimethoate and deltamethrin; thereafter, AChE activity showed 40% inhibition of the control level. The activity of aromatic esterase increased markedly after the first month, then declined gradually until the fifth month. High dose of dimethoate markedly inhibited this enzyme particularly after the 5th month of treatment. Both doses of deltamethrin increased ATPase activity after the first month of treatment, then the ATPase activity was normal. Dimethoate inhibited ATPase particularly at the end of treatment in a dose dependent manner.

Neurotoxic Effects of Cypermethrin in Wistar Rats: a Haematological, Biochemical and Histopathological Study

“…However, some authors reported that deltamethrin, a synthetic pyrethroid, had no significant effect on body weight. 26,27) In this regard, our findings are consistent with their results. In the current study, however, cypermethrin had no significant effect in total proteins of serum and brain.…”

“…In the current study, however, cypermethrin had no significant effect in total proteins of serum and brain. Shaker et al 27) found that serum total proteins of deltamethrin treated rabbits decreased in a dose dependent trend. Interestingly, Aziz et al 26) showed that the activity of AChE in hippocampal region significantly increased in 1 mg/kg deltamethrin-administered rats.…”

Toxicity of subacute oral administration of cypermethrin in rats with special reference to histopathological changes

“…This is supported by the result obtained in the present study in which cypermethrin was noted to decrease the level of total protein due to its enhanced catabolism. This result is consistent with the result of Shaker et al, [25] who showed that serum total proteins of deltamethrin-treated rabbits decrease in a dose-dependent manner.…”

Similarities and Differences between the Massive Eel (Anguilla anguillaL.) Devastations That Occurred in Lake Balaton in 1991 and 1995

“…Rose and Dewar state that DM has at least two distinct actions: a short-term pharmacological effect at near-lethal dose levels, and a more long-term neurotoxic effect that results in sparse axonal nerve damage. The literature contains many references to the secondary effects of DM on various parameters such as AChE, ATPases (Shaker et al, 1988), noradrenaline and adrenaline contents in rats (de Boer et al, 1988), choline transport (Matsumura, 1988), induction of chromosome aberrations in mice (Bhunya and Pati, 1990) and the subpopulations of muscarinic and nicotinic ACh receptors (Eriksson and Nordberg, 1990). From former experiments with carp by the authors, it appeared that during in vivo DM exposure at low dosage (1.5 g/liter) the AChE can be strongly inhibited in the heart, the midgut section, and the blood serum .…”