In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract

Dyary, Hiewa Othman; Arifah, A. K.; Sharma, R. S.; Rasedee, Ahmad Fadly Nurullah; Aspollah, Mohammed; Zakaria, Zuhaina; Zuraini, A.; Somchit, M. N.

doi:10.1016/j.rvsc.2015.03.007

Cited by 12 publications

(15 citation statements)

References 23 publications

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“…The greatest challenge facing the treatment of T. evansi infection today is the drug resistance and toxicity associated with the available chemotherapy (Baldissera et al, 2017). Natural products and their compounds are considered to be promising sources of new drugs and alternative treatment strategies to medicate trypanosomes (Habila et al, 2011, Dyary et al, 2015, Baldissera et al, 2017). In this context, the antitrypanosomal activity of LSSE was screened against T. evansi .…”

Section: Discussionmentioning

confidence: 99%

Therapeutic potential of the methanolic extract of Lepidium sativum seeds on mice infected with Trypanosoma evansi

Al-Otaibi

Al‐Quraishy

Al-Malki

et al. 2019

Saudi Journal of Biological Sciences

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The present study aimed to investigate the therapeutic potential of the methanolic extract of Lepidium sativum seeds in mice experimentally infected with Trypanosoma evansi. A total of thirty-two male Swiss albino mice were randomly divided into four groups: the first group was the normal control, while the second, third and fourth groups were infected intraperitoneally with 1 × 104 trypanosomes. The third and fourth groups were treated with 100 μl of Lepidium sativum seed extract (LSSE) at a dose of 200 mg/kg body weight intraperitoneally (infected + LSSEI) and orally (infected + LSSEO) respectively, once a day, for a period of four days.Parasitaemia was found to be significantly raised in the untreated infected group, reaching 2 × 107 at day 4 post-infection, but was significantly reduced by 65.5% and 88% in the mice treated orally and intraperitoneally with LSSE, respectively. The erythrocyte count, HCT, haemoglobin content, leucocyte count and the percentage of lymphocytes was significantly reduced in the untreated infected group, while the treatment with LSSE returned these parameters to their pre-infection values. In addition, our study proved that LSSE provided protection against liver tissue damage and decreased the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT). The present study also established that intraperitoneal injection of LSSE is more effective than oral administration in the treatment of trypanosome infection in mice. In conclusion, the infection caused haematological, biochemical and histological changes that were ameliorated following treatment with LSSE.

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Section: Discussionmentioning

confidence: 99%

Therapeutic potential of the methanolic extract of Lepidium sativum seeds on mice infected with Trypanosoma evansi

Al-Otaibi

Al‐Quraishy

Al-Malki

et al. 2019

Saudi Journal of Biological Sciences

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“…Previous research reported that the aqueous extract of G. hombroniana (seaushore mangosteen) has a potential antitrypanosomal activity through the inhibition of kinetoplast division, as one of the possible mechanisms of its antitrypanosomal effect. This plant could serve as a possible source of new antitrypanosomal compounds (Dyary et al 2015). Trypanocidal activity of free and nanoencapsulated curcumin against T. evansi was tested in vitro.…”

Section: Prevention and Controlmentioning

confidence: 99%

Insight into trypanosomosis (Surra) of Indian livestock: Recent updates

Singh

Maharana

2018

Indian J of Anim Sci

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Surra, caused by Trypanosoma evansi, is an economically important disease of a wide range of domestic and wild animals, and is most widely distributed. It is a potentially fatal disease causing huge economic losses to the livestock owners in terms of morbidity, mortality, abortion, infertility, reduced milk yield and also by interfering with vaccination programme in India. Due to sub clinical nature of the disease, it has been underestimated in cattle and buffaloes. Emergence of atypical cases of human trypanosomiasis has created an alarming situation and indicates a possible zoonotic threat in future. Accurate diagnosis of surra is extremely essential to identify animals for treatment, to assess the prevalence of the disease and to avoid indiscriminate usage of trypanocidal drugs. Diagnosis of surra still suffers from low sensitivity and specificity. There is an urgent need for sensitive cost effective penside diagnostic that can be applicable and affordable to smallholder farmers in endemic regions. The present review addresses various aspects of surra with special emphasis on disease epidemiology, emerging issues, current diagnostic trends, chemotherapeutics and preventive measures to limits its prevalence in livestock.

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“…The root is widely used in folk medicine as an anti-infective agent after birth and to relieve itchiness. Besides, the ethanolic extracts of this species have been shown to exhibit cytotoxicity, antitrypanosomal, antioxidation and antiplatelet aggregation activities (Saputri and Jantan, 2012;Dyary et al, 2015;Jamila et al, 2017). Although phytochemical analyses were performed on the pericarp, leaves, and twigs of G. hombroniana yielding compounds such as lanostanes, friedolanostanes, xanthones, biflavonoids and triterpenes (Klaiklay et al, 2013;Jamila et al, 2014aJamila et al, , 2014bJamila et al, , 2016, no phytochemical investigation has ever been performed on the roots of the G. hombroniana.…”

Section: Introductionmentioning

confidence: 99%