In vivo antioxidant effect of aqueous root bark, stem bark and leaves extracts of Vitex doniana in CCl4 induced liver damage rats

Adetoro, Kadejo Olubukola; James, Dorcas Bolanle; Abdullahi, Sallau Balarebe; Ahmed, Ozigi Abdulrahaman

doi:10.1016/s2221-1691(13)60083-0

Cited by 20 publications

(10 citation statements)

References 23 publications

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“…The elevated levels of ALT, AST, ALP reported in the current study in animals treated with CCl 4 , indicated severe hepatic parenchymal cell injury and were in agreement with the previous reports [72]- [75]. Moreover, CCl 4 was found to induce oxidative stress in hepatic tissue leading to accumulation of free radicals and consequently decreased activities of hepatic antioxidant enzymes; SOD, CAT and GPx with increased level of MDA indicating the oxidative damage to the hepatic tissue caused by CCl 4 [76]- [78]. 4 .…”

Section: Discussionsupporting

confidence: 92%

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

El-Denshary¹,

Aljawish²,

El‐Nekeety³

et al. 2015

SNL

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This study was conducted to prepare chitosan nanoparticles (CNPs), to determine their properties and to evaluate the synergistic protective role of CNPs alone or in combination with quercetin (Q) against oxidative stress and hepatotoxicity in rats. Female Sprague-Dawley rats were divided into 12 groups (7 rats/group) and were maintained on their respective diet for 3 weeks as follow: control group, the group treated with CCl4 (100 mg/kg b.w twice a week); the groups received CNPs at low and high doses (140 and 280 mg/kg b.w); the group received Q (50 mg/kg b.w); the groups received CNPs at the low or high doses plus Q and the groups treated with CCl4 plus Q and/or CNPs at the two tested doses. Blood and liver samples were collected at the end of experiment period for biochemical and histological studies. The results indicated that chitosan showed deacetylation degree of 17.5% and 19.2% and the molar mass average of monomer was 168.35 g/mol and 169.1 g/mol by UV and IR methods respectively. The particle size of CNPs was around 100 nm with a rough surface. The in vivo results revealed that CCl4 induced biochemical and histological changes typical to those reported in the literature. Animals treated with CNPs at the two tested doses alone or in combination with Q were comparable to the control. CNPs alone or plus Q succeeded to induce significant improvements in the biochemical parameters and histological picture of the liver in rats treated with CCl4. This improvement was in dose-dependent manner for CNPs and was * Corresponding author. E. S. El-Denshary et al. 37more pronounced in the group treated with the high dose plus Q. It could be concluded that both CNPs and Q could induce protection against hepatotoxicity. Consequently, CNPs was a promise candidate as drug delivery in liver diseases treatments.

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Section: Discussionsupporting

confidence: 92%

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

El-Denshary¹,

Aljawish²,

El‐Nekeety³

et al. 2015

SNL

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“…Drugs that lead to the depletion of GSH or influence the activity of any of these GSH-dependent enzymes may result in toxic responses. Glutathione makes a complex with NAPQI in the liver [50] and the depletion of the former increases the risk of hepatotoxicity [51]. CAT is an enzymatic antioxidant widely distributed in all animal tissues.…”

Section: Discussionmentioning

confidence: 99%

Volatile compounds and antioxidant activity of the aromatic herb Anethum graveolens

Ramadan¹,

Abd-Algader²,

EL-Kamali³

et al. 2013

J Arab Soc Med Res

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Background/Aim Anethum graveolens L. (dill) (Apiaceae) is one of the most popular culinary herbs in the world. Dill has been cultivated since ancient times, and the use of this plant for medicinal and consumption purposes has been recorded dating back to the Greek and Egyptian civilizations. Dill is widely used to give flavor to food. The aim of this work was to assess the chemical composition of the volatile compounds in dill as well as their hepatoprotective and nephroprotective activity against free radicals generated by paracetamol. Materials and methods The chemical composition of the volatile compounds of dill was assessed by gas chromatography and gas chromatography-mass spectrometry. Four groups of rats were used (the normal control group, the A. graveolens-supplemented group, the paracetamol-intoxicated group, and the A. graveolens-protected group) for studying the effect of plant infusion on panadol (paracetamol)induced free radicals and hepatotoxicity. Plasma total antioxidant capacity, plasma catalase, cellular glutathione peroxidase, plasma total protein, albumin, alanine amino transferase, aspartate amino transferase, alkaline phosphate, γ-glutamyl transferase, total bilirubin, and direct bilirubin levels were determined. In addition, kidney functions (plasma urea and creatinine) and histopathological and histochemical changes in the liver were investigated. Results The phytochemical results identified volatile components 7-α-hydroxy manool (24.43%), l-carvone (14.28%), limonene (13.9%), epi-α-bisabolol (6.81%), α-terpinene (5.44%), and α-phellandrene (4.63%) as the main constituents. p-Cymene (2.13%), sabinene (1.98), and α-pinene (1.43%) were determined as the minor constituents. The biochemical results showed that a mega dose of paracetamol induced the production of free radicals, which caused damage to hepatocytes and nephrocytes in rats. The aqueous extract of dill revealed high antioxidant properties and acted as an extracellular neutralizer of free radicals. Histopathological and histochemical observations showed severe damage in the liver. Supplementation with dill in paracetamol-intoxicated rats attenuated the damage to the liver. Conclusion The present study revealed that A. graveolens has antihepatotoxic properties that could minimize the deleterious effects generated by hepatotoxin paracetamol, and therefore it can be used as a potent antihepatotoxic agent.

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“…Processing the fleshy fruits provides juice, jam, syrup and alcohol ( Agbede and Ibitoye 2007 ; Mapongmetsem et al 2005 , 2008; Oumorou et al 2010 ; Ajenifujah-Solebo and Aina 2011 ; Vunchi et al 2011 ; Dadjo et al 2012 ). Also, new shoots and leaves are traditionally consumed as leafy vegetables ( Codjia et al 2003 ; Dansi et al 2008 ; Achigan-Dako et al 2011 ), and almost all parts of the plant have medicinal properties (anti-bacterial, anti-inflammatory, analgesic, anti-fungal, hepato-protective, anti-oxidant and hypotensive; Ladedji and Okoye 1996 ; Ladedji et al 1996 ; Ganapaty and Vidyadhar 2005 ; Iwueke et al 2006 ; Kilani 2006 ; Padmalatha et al 2009 ; Lagnika et al 2012 ; Adetoro et al 2013 ; Hamzah et al 2013 ). Overall, 25 diseases are known to be treated with Black plum ( Oumorou et al 2010 ; Dadjo et al 2012 ).…”

Section: Methodsmentioning

confidence: 99%

Reproductive traits affect the rescue of valuable and endangered multipurpose tropical trees

Sinébou¹,

Quinet²,

Ahohuendo³

et al. 2015

AoB PLANTS

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Conservation strategies are urgently needed for widely used tree species. Increasing numbers of species are threatened by overexploitation and their recovery might be poor due to low reproductive success, and poor regeneration rates. One of the first steps for any conservation policy should be an assessment of their reproductive biology. We studied the flowering biology, pollination, breeding system and germination potential of Vitex doniana, a multipurpose threatened African tree. Vitex doniana's breeding characteristics as well as germination performance offered the required conditions to develop successful conservation strategies. Protection and integration in agroforestry systems could improve the regeneration of the tree.

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In vivo antioxidant effect of aqueous root bark, stem bark and leaves extracts of Vitex doniana in CCl4 induced liver damage rats

Cited by 20 publications

References 23 publications

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

Possible Synergistic Effect and Antioxidant Properties of Chitosan Nanoparticles and Quercetin against Carbon Tetrachloride-Induce Hepatotoxicity in Rats

Volatile compounds and antioxidant activity of the aromatic herb Anethum graveolens

Reproductive traits affect the rescue of valuable and endangered multipurpose tropical trees

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