Volatile compounds and antioxidant activity of the aromatic herb Anethum graveolens

Ramadan, Manal M.; Abd-Algader, Nadia N.; EL-Kamali, Hatil Hashim; Ghanem, Kadry Z.; Farrag, Abdel Razik H.

doi:10.4103/1687-4293.123791

Cited by 24 publications

(17 citation statements)

References 47 publications

(45 reference statements)

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“…Therefore, Table 2 also shows the results of the β-carotene bleaching assay based on the loss in the yellow color of β-carotene due to its reaction with radicals produced during linoleic acid oxidation. The high inhibition effect of the oxidation of linoleic acid and the subsequent bleaching of β-carotene compared to TBHQ at the same concentration may be attributed to the presence of terpene hydrocarbons and oxygenated volatile compounds (Ramadan et al, 2013a). In both assays, the radical scavenging capacity of the tested EOs increased in a concentration dependent manner.…”

Section: Antioxidative Activitymentioning

confidence: 81%

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Essential oils from Egyptian aromatic plants as antioxidant and novel anticancer agents in human cancer cell lines

Ramadan¹,

Ali²,

Ghanem³

et al. 2015

Grasas y Aceites

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SUMMARY:Inhibitors of tumor growth using extracts from aromatic plants are rapidly emerging as important new drug candidates for cancer therapy. The cytotoxicity and in vitro anticancer evaluation of the essential oils from thyme, juniper and clove has been assessed against five different human cancer cell lines (liver HepG2, breast MCF-7, prostate PC3, colon HCT116 and lung A549). A GC/MS analysis revealed that α-pinene, thymol and eugenol are the major components of Egyptian juniper, thyme and clove oils with concentrations of 31.19%, 79.15% and 82.71%, respectively. Strong antioxidant profiles of all the oils are revealed in vitro by DPPH and β-carotene bleaching assays. The results showed that clove oil was similarly potent to the reference drug, doxorubicin in prostate, colon and lung cell lines. Thyme oil was more effective than the doxorubicin in breast and lung cell lines while juniper oil was more effective than the doxorubicin in all the tested cancer cell lines except prostate cancer. In conclusion, the essential oils from Egyptian aromatic plants can be used as good candidates for novel therapeutic strategies for cancer as they possess significant anticancer activity. KEYWORDS:Anticancer; Antioxidant; Clove Juniper; Thyme RESUMEN: Aceites esenciales de plantas aromáticas egipcias como novedosos agentes anticancerígenos y antioxidantes en líneas celulares de cáncer humano. Los inhibidores de crecimiento de tumores usando extractos de plantas aromáticas están emergiendo con rapidez como nuevos e importantes medicamentos para el tratamiento del cáncer. La citotoxicidad y la acción anticancerígena in vitro de aceites esenciales de tomillo, enebro y clavo han sido evaluadas en cinco líneas celulares de cáncer humano (hígado HepG2, mama MCF-7, próstata PC3, colon HCT116 y pulmón A549). Los análisis de GC/MS mostraron que α-pineno, timol y eugenol son los principales componentes de los aceites egipcios de enebro, tomillo y clavo, con concentraciones de 31,19%, 79,15% y 82,71%, respectivamente. Se demuestra, mediante ensayos in vitro de blanqueo de DPPH y β-caroteno, el enérgico perfil antioxidante de todos los aceites. Los resultados mostraron que el aceite de clavo fue similar de potente al fármaco de referencia, doxorrubicina en las líneas celulares de próstata, colon y pulmón. El aceite de tomillo fue más efectivo que la doxorrubicina en las líneas celulares de mama y de pulmón, mientras que el aceite de enebro fue más eficaz que la doxorrubicina en todas las líneas celulares de cáncer ensayados, excepto en la de cáncer de próstata. En conclusión, los aceites esenciales de plantas aromáticas egipcias se pueden utilizar como buenos candidatos para nuevas estrategias terapéuticas para el cáncer al poseer una significativa actividad anticancerígena

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Section: Antioxidative Activitymentioning

confidence: 81%

“…• to non-radical DPPH-H (Ramadan et al, 2013a). Numerous and diverse techniques are available to evaluate the antioxidant activities of specific compounds or complex mixtures such as EOs; however a single procedure cannot identify all the possible mechanisms characterizing an antioxidant.…”

Section: Antioxidative Activitymentioning

confidence: 99%

Essential oils from Egyptian aromatic plants as antioxidant and novel anticancer agents in human cancer cell lines

Ramadan¹,

Ali²,

Ghanem³

et al. 2015

Grasas y Aceites

View full text Add to dashboard Cite

show abstract

“…This is may be due to the presence of phenolic compound including flavonoids and proanthocyanidins in flower extracts. Furthermore, an excellent, dose dependent antioxidant activity have been reported for dill aqueous extract, percentages of inhibition are 87.5 and 89.7% at 400 μg/ml according to the β car otene linoleate and DPPH free radicals methods, respectively (Ramadan et al, 2013;Shyu et al, 2009).…”

Section: -30%mentioning

confidence: 99%

The Apiaceae: Ethnomedicinal family as source for industrial uses

Ahmad

Talou

Saad

et al. 2017

Industrial Crops and Products

148

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Plants from Api aceae family are commonly used for food, flavoring, fragrance and medical purposes; they are also known to be used as a household remedies sinoe antiquity. Recently, many experimental and biological investigations have been carried out in on:ler to validate the ethno-medicinal claims of plants belonging to this family. Moreover, rediscovery of this family can be responsible for launching a new generation of botanical chemicals for industrial applications. This review paper may help upcoming research activities on Apiaoeae family membersby giving up to date information on their main common features, their origins and traditional backgrounds. Furthermore, this review gathers and discusses the fragmented information described in literature concerning the chemical compoeition and the biological activities of essential oils and different extracts of some Apiaceae species, it illustrates also their potential for the development of pharmaoeutical, cosmetic products and other industrial uses. 1. General introduction Medicinal and aromatic plants have attracted the attention of re searchers worldwide as a major source of raw materials used in the pharmaceutical, cosmetic, flavor and perfumery industries. Despite the progress made in synthetic medication research, nowadays, the large numbers of drugs in use are derived from plants by applying modem technologies to traditional practices (Canter et al., 2005; Singh and Singh, 2001). Apiaceae family is one of the most important familles of flowering plants, which consists of 3780 species in 434 genera. lt is distributed throughout the world, mostly in the northem temperate regions and high altitudes in the tropics. The main common features of Apiaceae species are: aromatic herbaceous nature, altemate leaves with sheathing bases, hollow stems, small flowers, inflorescences determined in simple or compound umbel, and indehiscent fruits or seeds with oil ducts (Christensen and Brandt, 2006). This family is well known for its distinctive flavors due to the secretory cavities consisting of schizo genous oil ducts with resin, oil, or mucilage and located in the fruits, stems, leaves and roots (Berenba um, 1990). Apiaceae family pro vides a large number of plants which are used for different purposes including nutrition, medicine, beverages, spices, repellents, staining, cosmetics, fragrances and industrial uses. Ethnomedically, several plants of this family are used as home based remedies to treat various illnesses re lated to digestive, endocrine, reproductive and respiratory systems (Aéimovié and Kostadinovié, 2015). This family is rich in phytochem icals and secondary metabolites which are potential source of drugs Table 1 Ethno-medicinal uses of Apiaceae species and chemical composition of their seeds essential oils.

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“…The high concentrations of both polyphenols and volatile constituents in plant extracts account for their higher antioxidant activity [17][18][19] . Recently, plant extracts have been screened for anticancer activity to identify novel therapeutic strategies against cancer [20][21][22] .…”

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confidence: 99%

A comparative study on flavour components and therapeutic properties of unfermented and fermented defatted soybean meal extract

Ghanem

Mahran

Ramadan

et al. 2020

Sci Rep

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Microbial fermentation of plant material alters the composition of volatile and non-volatile plant natural products. We investigated the antioxidant, anticancer, and antiviral properties of extracts of defatted soybean meal fermented with Aspergillus fumigatus F-993 or A. awamori FB-133 using in vitro methods. Gas chromatography-mass spectrometry analysis of soybean meal fermented with A. awamori FB-133 and A. fumigatus F-993 identified 26 compounds with 11,14-octadecadienoic acid and methyl ester (63.63%) and 31 compounds with butylated hydroxytoluene (66.83%) and δ-myrcene (11.43%) as main constituents, respectively. The antioxidant activities of DSM extract were 3.362 ± 0.05 and 2.11 ± 0.02 mmol TE/mL, FDSM treated with A. awamori FB-133 were 4.763 ± 0.05 and 3.795 ± 0.03 mmol TE/mL and FDSM treated with A. fumigatus F-993 were 4.331 ± 0.04 and 3.971 ± 0.02 mmol TE/mL as determined by ABTS and FRAP assays, respectively. Both fermented extracts had better antioxidant activity than the unfermented extract as shown by multiple antioxidant activity assays. The concentration of fermented extracts required for 50% inhibition of cell viability was significantly lower than that of the unfermented extract when tested against the human liver cancer cell line HepG2 as shown by cell viability assays, indicating strong anticancer activity. The IC 50 values for DSM, FDSM with A. fumigatusF-993 and FDSM with A. awamori FB-133 were27, 16.88 and 8.60 μg/mL, respectively. The extract of FDSM with A. awamori FB-133 showed the strongest anticancer activity, compared to DSM and FDSM with A. FumigatusF-993 extracts. fermented extracts also reduced hepatitis A virus titres to a greater extent than unfermented extracts, thus showing strong antiviral property. Hepatitis A virus titres were reduced by 2.66 and 3 log 10 /0.1 mL by FDSM with A. fumigatusF-993 and FDSM by A.awamori FB-133, respectively, compared to DSM (5.50 log 10 /0.1 mL). Thus, the fermentation of soybean meal with A. fumigatusF-993 or A. awamori FB-133 improves the therapeutic effect of soybean extracts, which can be used in traditional medicine. Fermentation of plant materials causes a significant change in bioactive volatile and non-volatile components 1. Moreover, the concentrations of both flavonoids and the unsaturated fatty acid esters, as well, increase due to the fermentation of soybean. Extracts of fermented soybean have shown strong antioxidant, anti-breast cancer and antiviral activities 2. A growing major objective interest is to develop special catalytic systems (one-pot tandem), that integrate both the reactivity of a chemical catalyst and a selected active site of an enzyme 3. Fungi (as yeasts,

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Volatile compounds and antioxidant activity of the aromatic herb Anethum graveolens

Cited by 24 publications

References 47 publications

Essential oils from Egyptian aromatic plants as antioxidant and novel anticancer agents in human cancer cell lines

Essential oils from Egyptian aromatic plants as antioxidant and novel anticancer agents in human cancer cell lines

The Apiaceae: Ethnomedicinal family as source for industrial uses

A comparative study on flavour components and therapeutic properties of unfermented and fermented defatted soybean meal extract

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