In vivo antianxiety and antidepressant activity of Murraya paniculata leaf extracts

BackgroundBacterial infection is a potential risk factor for depression. However, little is known about the mechanistic link between bacterial endotoxin and depressive-like behaviors. The aim of the present study was to clarify whether liposaccharide (LPS) could induce depressive-like behaviors in mice via sequentially activating small GTPase RagA, mammalian target of rapamycin (mTOR), and p70S6K.MethodsC57BL/6 N mice were treated with 0.83 mg/kg LPS by intraperitoneal injection for 24 h. The animals were assessed for depressive-like behaviors by forced swim test and tail suspension test. The expression levels of RagA, mTOR, and p70S6K were determined in mice, primary cortical neurons, neural stem cells, and PC12 cells.ResultsLPS effectively induced depressive-like behaviors in mice. Biochemical examination revealed that LPS not only upregulated RagA expression but also activated mTOR/p70S6K pathway in mouse brains. LPS challenge also achieved a similar effect in primary cortical neurons, neural stem cells, and PC12 cells. Following the silencing of RagA expression with specific siRNA, LPS failed to induce mTORC1 translocation to the lysosomal membranes in PC12 cells. These results suggested that LPS might sequentially upregulate RagA and activate mTOR and p70S6K pathways in mice and neural stem cells.ConclusionsThis study for the first time demonstrated that LPS might induce depressive-like behaviors in mice via the upregulation of RagA and subsequent activation of mTOR/p70S6K pathway. Such information may highlight the RagA-mTOR-p70S6K signaling cascade as a novel therapeutic target for the development of new anti-depressant therapeutics.

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“…The depressive behaviors were assessed by forced swim test (FST) and tail suspension test (TST) as previously described [28–30].…”

Section: Methodsmentioning

confidence: 99%

Potential link between the RagA-mTOR-p70S6K axis and depressive-behaviors during bacterial liposaccharide challenge

Zhao

Lao

Cui

et al. 2019

J Neuroinflammation

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“…Antianxiety and antidepressant activities were reported for the leaves extract of M. paniculata in ethanol and chloroform solvents. Antianxiety activity was found due to the presence of coumarins and antidepressant activity was due to coumarins, phenols and alkaloids [38] …”

Section: Pharmacological Activities Of Murraya Paniculatamentioning

confidence: 99%

Diversity in Phytochemical Composition and Medicinal Value of Murraya paniculata

Rehman

Anila

Muzaffar

et al. 2023

Chemistry & Biodiversity

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Murraya paniculata is herbal medicinal plant which is traditionally being used for management of cardiovascular, intestinal and respiratory (air way) disorders. This evergreen plant of tropical regions is a member of Rutaceace family. The goal of this review is to analyze and report the biological activities and active phytochemicals reported from Murraya paniculata (M. paniculata) extracts and essential oil. The data was searched using different search engines and using specific key words including M. paniculata, herbal medicine, phytochemicals, extract, essential oil, pharmacological activities. M. paniculata has been found to have wide range of pharmacological activities, including antinociceptive, antianxiety, antioxidant, antidepressant, antibacterial, analgesic and anti-diabetic properties. A diverse range of phytochemicals, including phenols, coumarins, terpenoids, flavonoids, and alkaloids have been isolated from various portions of the plant and tested for a variety of biological activities. This review will provide more information and stimulate additional research to develop more effective and cost-efficient alternative medicine from this plant.

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“…These are the important processes of non‐rapid eye movement (REM) sleep, thus these flavonoids and related biomolecules influence sleep patterns and anxiety processes (Nami et al, 2020 ). Certain plant‐based bioactive compounds like valerenic acid, mahanimbine, and coumarins have sedative, anxiolytic, and antidepressant activities (Batra et al, 2018 ; Jung et al, 2015 ; Sharma et al, 2017 ). Studies have shown that valerenic acid has benzodiazepine‐like tranquilizing activity which acts by increasing the levels of gamma‐aminobutyric acid (GABA).…”

Section: Nutraceuticals and The Management Of Covidmentioning

confidence: 99%

Nutraceuticals and COVID‐19: A mechanistic approach toward attenuating the disease complications

Paudel

Patel

Vishwas

et al. 2022

Journal of Food Biochemistry

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Nutraceuticals have emerged as potential compounds to attenuate the COVID‐19 complications. Precisely, these food additives strengthen the overall COVID treatment and enhance the immunity of a person. Such compounds have been used at a large scale, in almost every household due to their better affordability and easy access. Therefore, current research is focused on developing newer advanced formulations from potential drug candidates including nutraceuticals with desirable properties viz, affordability, ease of availability, ease of administration, stability under room temperature, and potentially longer shelf‐lives. As such, various nutraceutical‐based products such as compounds could be promising agents for effectively managing COVID‐19 symptoms and complications. Most importantly, regular consumption of such nutraceuticals has been shown to boost the immune system and prevent viral infections. Nutraceuticals such as vitamins, amino acids, flavonoids like curcumin, and probiotics have been studied for their role in the prevention of COVID‐19 symptoms such as fever, pain, malaise, and dry cough. In this review, we have critically reviewed the potential of various nutraceutical‐based therapeutics for the management of COVID‐19. We searched the information relevant to our topic from search engines such as PubMed and Scopus using COVID‐19, nutraceuticals, probiotics, and vitamins as a keyword. Any scientific literature published in a language other than English was excluded. Practical applications Nutraceuticals possess both nutritional values and medicinal properties. They can aid in the prevention and treatment of diseases, as well as promote physical health and the immune system, normalizing body functions, and improving longevity. Recently, nutraceuticals such as probiotics, vitamins, polyunsaturated fatty acids, trace minerals, and medicinal plants have attracted considerable attention and are widely regarded as potential alternatives to current therapeutic options for the effective management of various diseases, including COVID‐19.

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In vivo antianxiety and antidepressant activity of Murraya paniculata leaf extracts

Cited by 17 publications

References 17 publications

Potential link between the RagA-mTOR-p70S6K axis and depressive-behaviors during bacterial liposaccharide challenge

Potential link between the RagA-mTOR-p70S6K axis and depressive-behaviors during bacterial liposaccharide challenge

Diversity in Phytochemical Composition and Medicinal Value of Murraya paniculata

Nutraceuticals and COVID‐19: A mechanistic approach toward attenuating the disease complications

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