In vivo anti-inflammatory and anti-allergic activities of cynaroside evaluated by using hydrogel formulations

Szekalska, Marta; Sosnowska, Katarzyna; Tomczykowa, Monika; Winnicka, Katarzyna; Kasacka, Irena

doi:10.1016/j.biopha.2019.109681

Cited by 45 publications

(21 citation statements)

References 36 publications

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“…Cynaroside was the most abundant phenolic compound in the range of 39.79–741.60 μg g −1 , with the highest amount detected in the ethanol extract. Such a compound was reported as anti-inflammatory and anti-allergic agent [ 36 ] and it has been detected frequently in S. atropurpurea L. from Egypt, but also in other Scabiosa species ( S. olgae, S. tenuis, and S. argentea ) [ 18 , 37 , 38 ]. Chlorogenic acid was present in all extracts with a value ranging from 6.08 to 657.78 μg g −1 , and relatively the highest amount was detected in ethanol extract.…”

Section: Resultsmentioning

confidence: 99%

Botanical and Genetic Identification Followed by Investigation of Chemical Composition and Biological Activities on the Scabiosa atropurpurea L. Stem from Tunisian Flora

et al. 2020

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Scarce information about the phenolic composition of Scabiosa atropurpurea L. is available, and no carotenoid compounds have been reported thus far. In this study the phenolic and carotenoid composition of this plant was both investigated and associated bioactivities were evaluated. Aiming to obtain extracts and volatile fractions of known medicinal plants to valorize them in the pharmaceutical or food industries, two techniques of extraction and five solvents were used to determine the biologically active compounds. Gas chromatography coupled to flame ionization and mass spectrometry and liquid chromatography coupled to photodiode array and atmospheric pressure chemical ionization/electrospray ionization mass spectrometry highlighted the presence of 15 volatiles, 19 phenolic, and 24 natural pigments in Scabiosa atropurpurea L. stem samples; among them, the most abundant were 1,8-cineole, chlorogenic acid, cynaroside, and lutein. Bioactivity was assessed by a set of in vitro tests checking for antioxidant, antibacterial, antifungal, and allelopathic (against Brassica oleracea L. and Lens culinaris Medik) effects. Scabiosa atropurpurea L. stem extracts presented a considerable antioxidant, antibacterial, and allelopathic potential, with less antifungal effectiveness. These results indicate that the volatile fractions and extracts from S. atropurpurea L. stem could be considered as a good source of bioactive agents, with possible applications in food-related, agriculture, and pharmaceutical fields. Genetic investigations showed 97% of similarity with Scabiosa tschiliensis, also called Japanese Scabiosa.

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Section: Resultsmentioning

confidence: 99%

Botanical and Genetic Identification Followed by Investigation of Chemical Composition and Biological Activities on the Scabiosa atropurpurea L. Stem from Tunisian Flora

et al. 2020

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“…For instance, to screen for new drugs, researchers use mouse paw edema test. [19] After induction of the inflammation by carrageenan, swelling of the paw is measured, and the antiinflammatory effect is presented as the decrease in the paw volume. Another model is arachidonic acid-induced mouse ear edema, which is measured using a thickness gauge.…”

Section: Evaluation Of Inflammatory Response To Biomaterialsmentioning

confidence: 99%

Recent Advances in Antiinflammatory Material Design

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Fournel

Lavalle

et al. 2020

Adv Healthcare Materials

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Implants and prostheses are widely used to replace damaged tissues or to treat various diseases. However, besides the risk of bacterial or fungal infection, an inflammatory response usually occurs. Here, recent progress in the field of anti‐inflammatory biomaterials is described. Different materials and approaches are used to decrease the inflammatory response, including hydrogels, nanoparticles, implant surface coating by polymers, and a variety of systems for anti‐inflammatory drug delivery. Complex multifunctional systems dealing with inflammation, microbial infection, bone regeneration, or angiogenesis are also described. New promising stimuli‐responsive systems, such as pH‐ and temperature‐responsive materials, are also being developed that would enable an “intelligent” antiinflammatory response when the inflammation occurs. Together, different approaches hold promise for creation of novel multifunctional smart materials allowing better implant integration and tissue regeneration.

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“…et al [ 36 ] designed SB-loaded solid lipid nanoparticle-enriched Carbopol gel whose topical application appears efficient in dinitrochlorobenzene-induced ICD in mice. Szekalska et al [ 62 ] tested an alginate-based HG, considered a suitable drug carrier for this kind of application due to its antiallergic and anti-inflammatory activities, incorporated with cynaroside (CYN) [a luteolin (LT) derivative]. Theses HGs were efficient for the treatment of atopic dermatitis, as demonstrated not only in a carrageenan-induced mouse paw edema inflammation model but also in an oxazolone-induced mouse allergic contact dermatitis model.…”

Section: Potential Biomedical Applications Of (Poly)phenols Loadedmentioning

confidence: 99%

“…The anti-inflammatory and anti-allergic properties of this flavonoid was evidenced by Szekalska M. et al in multiple alginate-based micro-HGs loaded with CYN ( Figure 3 ), that is, the naturally occurring 7- O -glucoside derivative of LT [ 62 ]. The glycoside was isolated from the extract of the aerial parts of Bidens tripartita and loaded into sodium alginate (which was chosen for its bioadhesive properties) HGs mixed with a variable amount of glycerol and/or propylene glycol.…”

Section: Hydrogels Projected For Topical Applicationsmentioning

confidence: 99%

Hydrogels for the Delivery of Plant-Derived (Poly)Phenols

et al. 2020

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This review deals with hydrogels as soft and biocompatible vehicles for the delivery of plant-derived (poly)phenols, compounds with low general toxicity and an extraordinary and partially unexplored wide range of biological properties, whose use presents some major issues due to their poor bioavailability and water solubility. Hydrogels are composed of polymeric networks which are able to absorb large amounts of water or biological fluids while retaining their three-dimensional structure. Apart from this primary swelling capacity, hydrogels may be easily tailored in their properties according to the chemical structure of the polymeric component in order to obtain smart delivery systems that can be responsive to various internal/external stimuli. The functionalization of the polymeric component of hydrogels may also be widely exploited to facilitate the incorporation of bioactive compounds with different physicochemical properties into the system. Several prototype hydrogel systems have been designed for effective polyphenol delivery and potential employment in the treatment of human diseases. Therefore, the inherent features of hydrogels have been the focus of considerable research efforts over the past few decades. Herein, we review the most recent advances in (poly)phenol-loaded hydrogels by analyzing them primarily from the therapeutic perspective and highlighting the innovative aspects in terms of design and chemistry.

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In vivo anti-inflammatory and anti-allergic activities of cynaroside evaluated by using hydrogel formulations

Cited by 45 publications

References 36 publications

Botanical and Genetic Identification Followed by Investigation of Chemical Composition and Biological Activities on the Scabiosa atropurpurea L. Stem from Tunisian Flora

Botanical and Genetic Identification Followed by Investigation of Chemical Composition and Biological Activities on the Scabiosa atropurpurea L. Stem from Tunisian Flora

Recent Advances in Antiinflammatory Material Design

Hydrogels for the Delivery of Plant-Derived (Poly)Phenols

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