In vivo anti-diabetic, antioxidant and molecular docking studies of 1, 2, 8-trihydroxy-6-methoxy xanthone and 1, 2-dihydroxy-6-methoxyxanthone-8-O-β-d-xylopyranosyl isolated from Swertia corymbosa

Mahendran, G.; Manickam, Manoj; Murugesh, E.; Kumar, R. Sathish; Shanmughavel, P.; Prasad, K. J. Rajendra; Bai, V. Narmatha

doi:10.1016/j.phymed.2014.06.011

Cited by 46 publications

(25 citation statements)

References 57 publications

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“…Lipid peroxidation (LPO) in the liver and kidney tissue was estimated according to Niehaus and Samuelsson (1968) method using the standard procedure described previously by Mahendran et al (2014a). Superoxide dismutase (SOD) activity was assayed according to the Marklund and Marklund (1974) method.…”

Section: Assessment Of Antioxidant Activitiesmentioning

confidence: 99%

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Gopinath

Muthusamy

Chellappan

et al. 2015

Pharmaceutical Biology

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Context Syzygium densiflorum Wall. ex Wight & Arn (Myrtaceae) has been traditionally used by local tribes of the Nilgiris, Tamil Nadu, India, for the treatment of diabetes, however, no definitive experimental studies are available. Objective This study investigates the antidiabetic, antihyperlipidaemic and antioxidant activities of ethanol extract of S. densiflorum (EFSD) fruits in streptozotocin (STZ) and nicotinamide (NA)-induced diabetic rats. Materials and methods Acute oral toxicity and oral glucose tolerance were assessed in normal rats. The antidiabetic, antihyperlipidaemic and antioxidant activities were investigated in STZ À NAinduced diabetic rats. Diabetic rats were orally administered with glibenclamide (10 mg/kg b.wt), EFSD (200, 400 and 800 mg/kg b.wt) for 28 d. Further, changes in the blood glucose level (BGL), biochemical parameters, antioxidants were observed and histology of pancreas was performed.Results No toxicity and lethality were observed. Results of the following parameters are represented by treated versus disease control (STZ + NA) groups. BGL (161.33 ± 22.8 versus 476.17 ± 56.58 mg/dl), glycosylated haemoglobin (5.285 ± 0.19 versus 8.05 ± 0.55%), urea (40.32 ± 1.96 versus 75.37 ± 2.91 mg/dl), uric acid (1.2 ± 0.07 versus 2.16 ± 0.05 mg/dl), total cholesterol (89.3 ± 5.14 versus 139.7 ± 5.95 mg/dl) and triglycerides (79.65 ± 2.52 versus 108.9 ± 3.61 mg/dl) were significantly decreased, whereas haemoglobin (11.75 ± 0.73 versus 7.95 ± 0.42 g/dl), high-density lipoprotein cholesterol (14.2 ± 1.11 versus 6.97 ± 0.84 mg/dl), total protein (45%) and liver glycogen (87%) were significantly increased in EFSD-treated diabetic group. Significant changes were observed in the enzymatic and non-enzymatic antioxidants in EFSDtreated groups (p50.001). Histopathological examination showed the regeneration of b-cells in Islets of Langerhans. Conclusion This study confirms the antidiabetic, antihyperlipidaemic and antioxidant activities of S. densiflorum fruits. ARTICLE HISTORY

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Section: Assessment Of Antioxidant Activitiesmentioning

confidence: 99%

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Gopinath

Muthusamy

Chellappan

et al. 2015

Pharmaceutical Biology

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“…G. acuta contains various different components including xanthones, iridoids and triterpenoids (Lv et al, 2009). Modern pharmacological studies have shown that xanthones are the main active compounds of G. acuta and possessed a lot of pharmacological and biological activities such as anti-tumor, protect cardiovascular, hypoglycemic, antioxidant, antibacterial and anti-inflammation activities (Shen et al, 2014;Marona et al, 2008;Ryu et al 2011;Mahendran et al, 2014;Al-Massarani et al, 2013;Zhang et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Determination and pharmacokinetic study of four xanthones in rat plasma after oral administration of Gentianella acuta extract by UHPLC–ESI–MS/MS

Wang

et al. 2015

Journal of Ethnopharmacology

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“…The search for protein targets of antioxidants revealed that these compounds might also act by interfering directly on the protein activities. Unfortunately, few studies in the literature have been focused to the binding between antioxidant molecules and specific protein targets As an example, the interaction of two antioxidants (i.e., 1, 2, 8-trihydroxy-6-methoxyxanthone and 1, 2-dihydroxy-6-methoxyxanthone-8-O-β-d-xylopyranosyl) with glucokinase, fructose-1,6-bisphosphatase 1, 11-β-hydroxysteroid dehydrogenase, and modeled protein sulfonylurea receptor has been investigated by in vivo and in silico assays3.…”

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confidence: 99%

A theoretical study on predicted protein targets of apple polyphenols and possible mechanisms of chemoprevention in colorectal cancer

Scafuri

Marabotti

Carbone

et al. 2016

Sci Rep

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We investigated the potential role of apple phenolic compounds in human pathologies by integrating chemical characterization of phenolic compounds in three apple varieties, computational approaches to identify potential protein targets of the compounds, bioinformatics analyses on data from public archive of gene expression data, and functional analyses to hypothesize the effects of the selected compounds in molecular pathways. Starting by the analytic characterization of phenolic compounds in three apple varieties, i.e. Annurca, Red Delicious, and Golden Delicious, we used computational approaches to verify by reverse docking the potential protein targets of the identified compounds. Direct docking validation of the potential protein-ligand interactions has generated a short list of human proteins potentially bound by the apple phenolic compounds. By considering the known chemo-preventive role of apple antioxidants’ extracts against some human pathologies, we performed a functional analysis by comparison with experimental gene expression data and interaction networks, obtained from public repositories. The results suggest the hypothesis that chemo-preventive effects of apple extracts in human pathologies, in particular for colorectal cancer, may be the interference with the activity of nucleotide metabolism and methylation enzymes, similarly to some classes of anticancer drugs.

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In vivo anti-diabetic, antioxidant and molecular docking studies of 1, 2, 8-trihydroxy-6-methoxy xanthone and 1, 2-dihydroxy-6-methoxyxanthone-8-O-β-d-xylopyranosyl isolated from Swertia corymbosa

Cited by 46 publications

References 57 publications

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats

Determination and pharmacokinetic study of four xanthones in rat plasma after oral administration of Gentianella acuta extract by UHPLC–ESI–MS/MS

A theoretical study on predicted protein targets of apple polyphenols and possible mechanisms of chemoprevention in colorectal cancer

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