In vivo anthelmintic activity of Anogeissus leiocarpus Guill &amp; Perr (Combretaceae) against nematodes in naturally infected sheep

Soro, D.; Koné, Witabouna Mamidou; Bonfoh, Bassirou; Dro, B.; Toily, Kassédo Bénédicte; Kamanzi, Kagoyire

doi:10.1007/s00436-013-3435-y

Cited by 25 publications

(9 citation statements)

References 37 publications

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“…In contrast, a lesser faecal egg count reduction was observed by Strickland et al (2007) when pumpkin kernel was administered to the animals instead of extracts which are expected to contain higher level of the active ingredients. Similar findings were also recorded by Mesquita and Batista (2013) with Eucalyptus staigeriana essential oil; with banana crop residues; Soro et al (2013) with ethanolic extract of Anogeissus leiocarpus and Ahmed et al (2014) by using Lespedeza cuneata.…”

Section: Effect Of Plant Extracts On Haematological and Serum Biochemsupporting

confidence: 75%

Anthelmintic evaluation of Cucurbita pepo againstgastrointestinal nematodes of sheep

Meenakshisundaram¹,

Harikrishnan²,

Anna³

2017

IJAR

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The study was aimed at to investigate the anthelmintic efficacy of aqueous and ethanolic extracts of Cucurbita pepo against gastrointestinal nematodes of sheep by scientifically validated in vitro and in vivo tests. In vitro anthelmintic activity was determined by egg hatch assay, larval migration inhibition assay and larval development assay against eggs and larvae of mixed gastrointestinal nematodes of sheep. The extracts which were found to be effective in in vitro assays were further evaluated by in vivo faecal egg count reduction test against mixed species of sheep gastrointestinal nematodes with 3 different doses (125, 250 and 500 mg kg -1 ). Haematological and serum parameters were estimated before and after treatment to determine the impact of plant extracts on health of the animal. Aqueous extract of C. pepo demonstrated significant inhibition of egg hatch at 40 and 80 mg/ml. The ED 50 value of egg hatch inhibition was 3.51mg/ml. In larval migration inhibition assay, both aqueous and ethanolic extracts of C. pepo demonstrated inhibition of larval migration and the LM 50 was 1.75 and 0.32 mg/ml respectively. However, in larval development assay, both aqueous and ethanolic extracts showed only marginal inhibition of larval development at all concentrations tested. In faecal egg count reduction test (FECRT), aqueous extracts of C. pepo at 500 mg/kg caused significant reduction in eggs per gram (96.61 per cent) the reduction being higher than the result obtained with albendazole, the positive control (93.25 per cent). There was a significant difference in EPG reduction between sheep treated with albendazole and C. pepo. Haematological and serum parameters were not affected in both the treated and untreated sheep indicating that the extracts did not cause toxic effects. Based on the results obtained in this study, the aqueous extract of C. pepo possesses anthelmintic activity and could offer an alternative source for the control of gastrointestinal nematodes of sheep.

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Section: Effect Of Plant Extracts On Haematological and Serum Biochemsupporting

confidence: 75%

Anthelmintic evaluation of Cucurbita pepo againstgastrointestinal nematodes of sheep

Meenakshisundaram¹,

Harikrishnan²,

Anna³

2017

IJAR

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“…The highest percent FECR (47.78%) recorded with ethanolic extract of I. tinctoria was in agreement with Soro et al . [ 21 ] who recorded a 81% FECR at a single oral dose of 80 mg/kg 3 weeks post-treatment using ethanolic extract of Anogeissus leiocarpus in sheep naturally infected with GI nematodes. The results were in par with the findings recorded by Mesquita Mde and Batista [ 22 ] with Eucalyptus staigeriana essential oil, banana crop residues [ 23 ] and Lespedeza cuneata [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Anthelmintic activity of Indigofera tinctoria against gastrointestinal nematodes of sheep

Meenakshisundaram¹,

Harikrishnan²,

Anna³

2016

Vet World

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Aim:Gastrointestinal (GI) nematodes are considered as a major constraint for successful sheep production. Control of these parasites heavily relies on the use of chemical anthelmintics. Over the past decades, the development of anthelmintic resistance to various groups of anthelmintics and problem of drug residues in animal products has awakened interest in medicinal plants as an alternative source of anthelmintics. Hence, this study was undertaken to evaluate the anthelmintic efficacy of Indigofera tinctoria by scientifically validated in vitro and in vivo tests approved by the World Association for the Advancement of Veterinary Parasitology.Materials and Methods:In vitro assays such as egg hatch assay for ovicidal and larval migration inhibition and larval development assay for larvicidal properties were used to investigate in vitro effect of extracts on strongyle egg and larvae, respectively. Fecal egg count reduction test was conducted in vivo to evaluate the therapeutic efficacy of the extracts administered orally at dose rates of 125, 250, 500 mg/kg to sheep naturally infected with mixed GI nematodes.Results:Ethanolic extract of I. tinctoria demonstrated significant (p<0.01) inhibition on egg hatching at concentrations of 40 mg/ml and 80 mg/ml. In in vivo assay, the ethanolic extract of I. tinctoria reduced the fecal egg count ranging between 30.82% and 47.78% at various doses (125, 250 and 500 mg/kg). Although there was a slight variation, all the hematological parameters were within the normal range reported for sheep. Except for alanine transaminase, the overall mean of all the serum biochemical profile was within the normal range for sheep.Conclusion:Based on the results obtained by in vitro and in vivo assay, the ethanolic extract of I. tinctoria possesses anthelmintic activity and could replace the chemical anthelmintics used presently.

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“…Several plants are currently being investigated to identify available anthelmintic agents for using in animals (Aguilar et al, 2008;Shai et al, 2009;Alonso-Díaz et al, 2010). Soro et al (2013) also reported anthelmintic efficacy of Anogeissus leiocarpus Guill & Perr (Combretaceae) and improvement of body weight after in vivo treatment in sheep. M. paniculata, an important medicinal plant in Thailand, showed presently a significant fecal egg reduction and an increase in body weight in the M. paniculata treated goats.…”

Section: Discussionmentioning

confidence: 99%

In vivo Efficacy of Murraya paniculata Leaf in Controlling Natural Helminthiasis in Goat

Boonkusol

Detraksa

Duangsrikaew

et al. 2019

American Journal of Animal and Veterinary Sciences

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This study investigated the in vivo effect of Murraya paniculata leaf on gastrointestinal nematodes reduction, growth rates and haematological changes of goats. Four experimental groups (n = 6) of goats naturally acquired gastrointestinal nematodes were control (GI) (untreated), positive control (GII) (treated with albendazole, 6 mg/Kg BW) and GIII and GIV treated with 5 and 10 g/Kg BW of M. paniculata leaves. Fecal samples collections were performed weekly for assessment of fecal egg count. Number of nematode eggs in goat feces (egg per gram; EPG) was determined from week 0 (pre-treatment) to week 8 (post-treatment) by modified McMaster egg counting technique. EPG values of GIV goats were significantly lower than that of the controls and those receiving the albendazole (p<0.05) at week 3. GII goats showed highly effective at EPG reduction in 1-2 weeks after giving albendazole and then the efficiency decreased until the end of the experiment. The effect of M. paniculata leaves on growth rate was studied by examining goat weight on days 0, 30, 60 and 90. GIV group revealed significantly higher weight change than other groups (p<0.05). The feeding of M. paniculata leaves at different levels did not affect on haematological parameters, glucose, total protein, urea, albumin and globulin of goats. It was found that values of the haematological parameters were within the range of the standard values. Compound analysis of M. paniculata leaves revealed that M. paniculata leaves contained higher protein content than grass and the protein content was closed to the meal concentrate. This corresponds to the best growth rates of GIV goats. The results demonstrated that M. paniculata leaves reduce the gastrointestinal nematode eggs of goats efficiently, safely and environment-friendly.

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In vivo anthelmintic activity of Anogeissus leiocarpus Guill & Perr (Combretaceae) against nematodes in naturally infected sheep

Cited by 25 publications

References 37 publications

Anthelmintic evaluation of Cucurbita pepo againstgastrointestinal nematodes of sheep

Anthelmintic evaluation of Cucurbita pepo againstgastrointestinal nematodes of sheep

Anthelmintic activity of Indigofera tinctoria against gastrointestinal nematodes of sheep

In vivo Efficacy of Murraya paniculata Leaf in Controlling Natural Helminthiasis in Goat

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