In vivo and liver microsomal metabolism of diflubenzuron by two breeds of chickens

Opdycke, Joseph C.; Miller, Richard W.; Menzer, Robert E.

doi:10.1021/jf00114a056

Cited by 11 publications

(4 citation statements)

References 8 publications

(19 reference statements)

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“…Quail microsomes incubated at 37 °C metabolized fenvalerate at a slower rate than when incubated at 42 °C, the body temperature of birds (Figure 3). Since most of the in vitro methods for birds are adapted from mammalian methods, the temperature factor is overlooked (Opdycke et al, 1982;Akhtar, 1983). However, incubation temperature could have a bearing on the outcome of results, particularly in comparative metabolism studies between different species, and should be included in the design of such experiments.…”

Section: Resultsmentioning

confidence: 99%

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Comparative metabolism and fate of fenvalerate in Japanese quail (Coturnix coturnix japonica) and rats (Rattus norwegicus)

Mumtaz¹,

Menzer²

1986

J. Agric. Food Chem.

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Japanese quail were administered 100 mg/kg chlorophenyl-labeled [UC] fenvalerate, a-cyano-3phenoxybenzyl 2-(4-chlorophenyl)isovalerate, for study of its distribution, elimination, and metabolism. Ninety percent of the administered dose was eliminated in the excreta within the first 24 h. In addition to fenvalerate, the following metabolites were present: benzeneacetic acid, 4-chloro-a-(l-methylethyl)-, cyano(3-phenoxy-4-hydroxyphenyl)methyl ester [4'-OH-fenvalerate]; benzeneacetic acid, 4-chloro-a-(1-methylethyl)-, (aminocarbonyl)(3-phenoxyphenyl)methyl ester [CONH2-fenvalerate]; 4-chloro-a-(lmethylethyl)benzeneacetic acid [Cl-V acid]; 4-chloro-a-(2-hydroxy-1-methylethyl)benzeneacetic acid [4-OH-C1-V acid].In time course studies radiocarbon peaked at 3 h (9 pg/g) in the liver and gradually declined, while in the blood it peaked within 2 h and fell quickly to an equilibrium value of 1.5 pg/mL blood. In liver microsomal and isolated heptatocyte preparations of Japanese quail and rat, the following metabolites were identified: Cl-V acid, 4-OH-C1-V acid, 4'-OH-fenvalerate, CONH2-fenvalerate. Oxidation was found to be the predominant route of degradation either pre-or posthydrolysis of the parent compound. Rapid excretion, lesser absorption, and faster metabolism probably explain the lower toxicity of fenvalerate to birds compared to rats.

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Section: Resultsmentioning

confidence: 99%

“…Microsomal Assay. In order to assess the microsomal activity the conversion of aldrin to dieldrin was measured (Opdycke et al 1982). Fenvalerate incubations were carried out in 25-mL Erlenmyer flasks.…”

Section: Methodsmentioning

confidence: 99%

Comparative metabolism and fate of fenvalerate in Japanese quail (Coturnix coturnix japonica) and rats (Rattus norwegicus)

Mumtaz¹,

Menzer²

1986

J. Agric. Food Chem.

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“…85) Furthermore, strain differences in the metabolic profiles were reported for [Ph- 14 C]diflubenzuron between White Leghorn hens (WL) and Rhode Island Red/Barred Plymouth Rock (RIR/BPR) chickens. 115,134) The faster uptake and elimination of 14 C were observed in the RIR/BPR strain than in the WL strain, and the major elimination route was different between RIR/BPR (excreta) and WL (eggs). The same metabolites were detected in both strains but with different profiles of the bond cleavage in the benzoylurea bridge connecting the two phenyl groups.…”

Section: Species Differencesmentioning

confidence: 99%

Acute toxicity and metabolism of pesticides in birds

Katagi

Fujisawa

2021

J. Pestic. Sci.

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The median lethal dose of pesticide in acute oral toxicity, used as a conservative index in avian risk assessment, varies by the species with differences of less than one order of magnitude, depending on body size, feeding habit, and metabolic enzyme activity. The profiles of pesticide metabolism in birds with characteristic conjugations are basically common to those in mammals, but less information is available on their relevant enzymes. The higher toxicity of some pesticides in birds than in mammals is due to the lower activity of avian metabolic enzymes. The bioaccumulation in birds is limited for very hydrophobic pesticides resistant to metabolic degradation. Several in silico approaches using the descriptors of a pesticide molecule have recently been employed to estimate the profiles of acute oral toxicity and bioaccumulation.

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“…Residues in eggs ranged from 0.16 (RIR) to 0.25 (WL) mg/kg 3–6 days after treatment. Residues in body fat were very low, 0.007 mg/kg (WL) to 0.043 mg/kg (RIR) [223, 225]. In an already mentioned study [210] where hens received medicated feed containing 10 ppm diflubenzuron for 15 weeks, residues in eggs reached 0.38–0.55 ppm.…”

Section: Fate Of Bpus In Treated Domestic Animals and Fishmentioning

confidence: 99%

Benzoylphenyl ureas as veterinary antiparasitics. An overview and outlook with emphasis on efficacy, usage and resistance

Junquera¹,

Hosking²,

Gameiro³

et al. 2019

Parasite

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Six benzoylphenyl ureas are currently used in formulations approved as veterinary medicines: diflubenzuron for fly control mainly on cattle, lice and blowfly strike control on sheep, and lice control on farmed salmonids; lufenuron for flea control on dogs and cats and for lice control on farmed salmonids; triflumuron for lice and blowfly strike control on sheep; fluazuron for tick control on cattle; teflubenzuron for lice control on farmed salmon; and novaluron for fly and tick control on cattle and for flea control on dogs. Resistance to diflubenzuron and triflumuron has already been reported for sheep body lice and blowflies, and to fluazuron in cattle ticks. These and other minor veterinary usages, as well as the current status of resistance, are reviewed and perspectives for future opportunities are discussed based on unexplored potentials and threats posed by future resistance development.

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In vivo and liver microsomal metabolism of diflubenzuron by two breeds of chickens

Cited by 11 publications

References 8 publications

Comparative metabolism and fate of fenvalerate in Japanese quail (Coturnix coturnix japonica) and rats (Rattus norwegicus)

Comparative metabolism and fate of fenvalerate in Japanese quail (Coturnix coturnix japonica) and rats (Rattus norwegicus)

Acute toxicity and metabolism of pesticides in birds

Benzoylphenyl ureas as veterinary antiparasitics. An overview and outlook with emphasis on efficacy, usage and resistance

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