In vivo and in vitro Ovarian Steroidogenesis in the Pregnant Rat

Taya, Kazuyoshi; Greenwald, Gilbert S.

doi:10.1095/biolreprod25.4.683

Cited by 118 publications

(75 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oestradiol concentrations in the corpus luteum increase in the second half of pregnancy (Taya and Greenwald, 1981) and oestradiol inhibits IGF-I receptor expression both in vivo (Parmer et ah, 1991) and in vitro, as observed in the present study.…”

Section: Discussionsupporting

confidence: 82%

Regulation and role of the insulin-like growth factor I system in rat luteal cells

Sugino

Telleria²,

Tessier³

et al. 1999

Reproduction

View full text Add to dashboard Cite

The relationship between insulin-like growth factor I (IGF-I), a hormone which has potent metabolic effects and stimulates protein synthesis, and prolactin and oestradiol was examined to investigate a possible mechanism for the luteal cell hypertrophy that is responsible for the increase in size of the corpus luteum. A luteal cell line (GG-CL) derived from large luteal cells of the pregnant rat corpus luteum was used. IGF-I,

show abstract

Section: Discussionsupporting

confidence: 82%

Regulation and role of the insulin-like growth factor I system in rat luteal cells

Sugino

Telleria²,

Tessier³

et al. 1999

Reproduction

View full text Add to dashboard Cite

show abstract

“…This was to be expected, since LH levels exhibit very low values on day 15 (Morishige et al 1973, Taya & Greenwald 1981. However, when the addition of LH to the ovary was accompanied by the addition of NE, Prop or Ph to the ganglionic compartment, progesterone production fell.…”

Section: Figurementioning

confidence: 79%

Coeliac ganglion adrenergic activity modifies ovarian progesterone during pregnancy: its inter-relationship with LH

Casais

Sosa²,

Rastrilla³

et al. 2001

Journal of Endocrinology

View full text Add to dashboard Cite

Most of the fibres that constitute the superior ovarian nerve (SON) originate at the neuronal bodies of the coeliac ganglion and innervate rat ovarian stroma cells. The purpose of this work was to study the part played by innervation on ovarian release of progesterone on day 15 and at the end of pregnancy in an integrated in vitro system known as the coeliac ganglion-SON-ovary system.We also investigated, in the same system, whether there is some kind of inter-relationship between the effect of adrenergic agents and LH on progesterone release on day 15 of pregnancy.The coeliac ganglion and the ovary were incubated in separate compartments, linked by the SON. The ovary was immersed in 2 ml buffer solution (ovarian compartment) and the coeliac ganglion was immersed in 2 ml of a different buffer solution (ganglion compartment). Under these conditions, the accumulation of progesterone in the ovarian compartment medium was used as an endpoint. Conditions were standardised on day 15 of pregnancy, when the decrease in the release of ovarian progesterone caused by non-specific stimulation on the ganglion with KCl (56 mM) demonstrated the functional integrity of the system. Neural influence was evaluated by the addition of adrenergic agents at a concentration of 10 6 M to the coeliac ganglion. On day 15 of pregnancy, noradrenaline and propranolol increased progesterone release while phentolamine diminished it. The existence of ganglionic tone was assessed by analysing progesterone basal levels at different stages of pregnancy. The highest secretion of progesterone was found to take place on day 15, diminishing as pregnancy advanced. In addition, adrenergic neural participation was studied during the physiological luteolysis occurring at the end of pregnancy. Major findings were that noradrenaline increased ovarian accumulation of progesterone on day 19 and decreased it on day 20, while propranolol and phentolamine diminished progesterone release on both days. In additional studies, some neuroendocrine aspects were investigated at a peripheral level. The addition of LH only to the ovarian compartment did not affect progesterone secretion. However, when LH in the ovarian compartment was accompanied by noradrenaline, propranolol or phentolamine in the ganglion compartment, the release of progesterone decreased.It can be concluded that modifications of the neural state of the coeliac ganglion affect ovarian progesterone secretion and the physiology of pregnancy via the SON. The results may confirm that the coeliac ganglion-SONovary system provides a direct link between the autonomic nervous system and physiological events during pregnancy.

show abstract

“…The increased coagulant activity was not affected by et al, 1990). In this connection, Taya and Greenwald (1981) reported that with the progression of pregnancy and reached the highest level just before delivery. Therefore, the decrease in the anticoagulant effect of warfarin observed in pregnant concentration in pregnant rats.…”

Section: Discussionmentioning

confidence: 91%

“…In addition, also change with the progression of pregnancy (William, 2005;Taya and Greenwald, 1981;Sakamoto et al, 1979Sakamoto et al, , 1982. The present study was carried out to clarify the effects of pregnancy and lactation on warfarin-induced changes in blood coagulation-related parameters including factor VII and X activities in rats.…”

Section: Introductionmentioning

confidence: 91%

Effects of pregnancy and lactation on warfarin-induced changes in blood coagulation-related parameters in rats

et al. 2010

View full text Add to dashboard Cite

-Effects of pregnancy and lactation on warfarin-induced changes in blood coagulationrelated parameters were examined in rats. Warfarin (0.5 mg/kg/day) was given orally to pregnant and nonpregnant rats for 3 days from gestation day (GD) 17 to 19 or to lactating and non-pregnant rats for 3 days from post partum day (PPD) 10 to 12. Blood samples were collected from the rats on the day following the last administration (GD 20 or PPD 13) to measure prothrombin time (PT), activated partial thrombo---changes were observed in lactating rats. The reduction of the anticoagulant effects of warfarin may parconcentration in lactating rats, respectively.

show abstract

In vivo and in vitro Ovarian Steroidogenesis in the Pregnant Rat

Cited by 118 publications

References 32 publications

Regulation and role of the insulin-like growth factor I system in rat luteal cells

Regulation and role of the insulin-like growth factor I system in rat luteal cells

Coeliac ganglion adrenergic activity modifies ovarian progesterone during pregnancy: its inter-relationship with LH

Effects of pregnancy and lactation on warfarin-induced changes in blood coagulation-related parameters in rats

Contact Info

Product

Resources

About