Regulation and role of the insulin-like growth factor I system in rat luteal cells

Sugino, Norihiro; Telleria, Carlos; Tessier, C.; Gibori, Gil B.

doi:10.1530/jrf.0.1150349

Cited by 15 publications

(13 citation statements)

References 7 publications

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“…The results also indicate that there is a feedback mechanism between IGF-I and estradiol. The steroid downregulates the concentration of the IGF-I receptor and its ligand (27). Therefore, synergistic actions of IGF-I and estradiol on GnRH-stimulated LH secretion might occur predominantly at low concentrations of IGF-I, as observed in the present study.…”

Section: Discussionsupporting

confidence: 73%

“…There is accumulating evidence that estradiol indirectly regulates the synthesis and secretion of LH through alteration of IGF-I action. These findings suggest that IGF-I might be a candidate target of estromedin (26,27), and furthermore, it might contribute to the modulation of LH secretion by the anterior pituitary. A limited amount of data indicate that IGF-I is able to increase LH release from male rat pituitary cells (4,28).…”

Section: Introductionmentioning

confidence: 82%

“…Recently a study by Sugino et al (27) indicated that this synergistic effect involves, at least in part, IGF-Istimulated estradiol receptor mRNA expression. Therefore, IGF-I may also sensitize pituitary cells to estradiol action by upregulating estradiol receptor expression.…”

Section: Discussionmentioning

confidence: 99%

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Interactions of insulin-like growth factor-I, insulin and estradiol with GnRH-stimulated luteinizing hormone release from female rat gonadotrophs

Xia¹,

Weiss²,

Polack³

et al. 2001

European Journal of Endocrinology

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Background: It is well established that ovarian steroids modulate gonadotropin secretion from anterior pituitary cells. It has been speculated that insulin and IGF-I might influence gonadotropin secretion. Objective: To investigate the effects of IGF-I and estradiol alone, or combinations of IGF-I with insulin and estradiol on GnRH-stimulated LH release from female rat pituitary cells in serum-supplemented and serum-free culture conditions. Methods: Pituitary cells were incubated for 24 h or 48 h with a series of increasing concentrations of IGF-I or estradiol and stimulated with 1 nmol/l GnRH for 3 h. To determine the interaction of IGF-I and estradiol on GnRH-stimulated LH secretion, cells were exposed to increasing concentrations of IGF-I and 100 pmol/l estradiol for 24 h. We also investigated the effects of combined treatment with IGF-I and insulin on GnRH-stimulated LH secretion. Results: Our findings indicate that long-term IGF-I treatment (24 h) alone has a significant augmenting effect on GnRH-stimulated LH release in serum-free medium only, with a maximum at low concentrations (10 and 100 pmol/l). Estradiol significantly increased GnRH-induced LH release in a dose-dependent manner. The extent of GnRH-stimulated LH secretion by long-term estradiol treatment (24 h) was significantly greater in serum-supplemented (+42%) medium than in serumfree medium. Estradiol facilitated IGF-I-primed LH responses to GnRH in serum-free medium. In contrast, in serum-supplemented medium, the facilitating potential of estradiol was lower. We also found that, in GnRH-stimulated cells, LH release was augmented by insulin treatment, in contrast to quiescent cells that had been pretreated with 100 pmol/l IGF-I alone and 1 nmol/l insulin alone. Conclusions: IGF-I and to a lesser extent insulin stimulate GnRH-induced LH secretion from pituitary gonadotrophs. This action is enhanced by estradiol treatment of the cells. However, the well known stimulatory action of estradiol on LH secretion is dependent on the presence of growth factors.

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Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 82%

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Interactions of insulin-like growth factor-I, insulin and estradiol with GnRH-stimulated luteinizing hormone release from female rat gonadotrophs

Xia¹,

Weiss²,

Polack³

et al. 2001

European Journal of Endocrinology

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show abstract

“…Cependant, l'hypothèse d'un éventuel impact des antagonistes du GnRH sur les cellules lutéinisées de la granulosa ne peut être exclue et mériterait d'être étudiée. L'IGF-1 joue un rôle important dans la formation et le fonctionnement du corps jaune [30,31]. Dès le début de la formation du corps jaune, en présence d'un taux élevé d'antagoniste du GnRH, on observe une inhibition de l'action des IGF associée à une diminution du taux de sécrétion de la progestérone par les cellules de la granulosa.…”

Section: Discussionunclassified

Les antagonistes du GnRH : effets biologiques

Devaux

Pouly

Bachelot

et al. 2004

Gynécologie Obstétrique & Fertilité

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“…The action of GH is partly mediated by insulin-like growth factor 1 (IGF-1) production from the liver (3,7,8). Both GH and IGF-1 are detected in human follicular fluid (8)(9)(10)(11)(12)(13), and their receptors also are expressed in the ovary (14)(15)(16)(17). The role of GH and IGF-1 in follicular development has been examined in several species, including humans (8,(18)(19)(20)(21)(22)(23).…”

mentioning

confidence: 99%

Effects of growth hormone and insulin-like growth factor 1 on progesterone production in human luteinized granulosa cells

Tanaka

Yamagata

Takasaki

et al. 2008

Fertility and Sterility

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Regulation and role of the insulin-like growth factor I system in rat luteal cells

Cited by 15 publications

References 7 publications

Interactions of insulin-like growth factor-I, insulin and estradiol with GnRH-stimulated luteinizing hormone release from female rat gonadotrophs

Interactions of insulin-like growth factor-I, insulin and estradiol with GnRH-stimulated luteinizing hormone release from female rat gonadotrophs

Les antagonistes du GnRH : effets biologiques

Effects of growth hormone and insulin-like growth factor 1 on progesterone production in human luteinized granulosa cells

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