In vivo and in vitro MR spectroscopic profile of central neurocytomas

Jayasundar, Rama; Shah, Tariq; Vaishya, Sandeep; Singh, Vishwadeep; Sarkar, Chitra

doi:10.1002/jmri.10252

Cited by 33 publications

(30 citation statements)

References 16 publications

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“…There are only a few reports on in vivo MRS of intraventricular central neurocytomas (4,(9)(10)(11)(12)(13)(14)(15) and two on extraventricular neurocytoma (13,16). The presence of Gly in CNCs was more consistently observed in the present study, including other CNCs studies from Kim et al (11), Yeh et al (15), Krishnamurthy et al (12), and Majos et al (3).…”

Section: Central Neurocytomassupporting

confidence: 79%

In vivo MRS study of intraventricular tumors

Shah

Jayasundar

Singh

et al. 2011

Magnetic Resonance Imaging

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Purpose: To evaluate the role of MR spectroscopy (MRS) as a noninvasive tool for characterization of intraventricular brain tumors. tumor each of rhabdoid tumor, glioneuronal hamartoma, GBM, hemangiopericytoma, and subependymoma II), were studied by MRS before surgery using a pointresolved spectroscopic sequence (PRESS).Results: Statistically significant differences (P < 0.03) were observed for NAA/Cr and Cho/Cr between CNCs and OIV. A significant difference (P < 0.01) was observed in the presence of Gly between the CNCs and meningiomas, and CNCs and OIV. In addition, the presence of Ala was also significantly different (P < 0.01) between OIV and meningiomas, and OIV and CNCs. Conclusion:The present study has shown that MRS can be useful in characterizing intraventricular tumor and distinguishing CNCs from meningiomas and other intraventricular tumors. Prior information about intraventricular tumor types could be useful to clinicians in planning treatment and resection strategy.

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Section: Central Neurocytomassupporting

confidence: 79%

In vivo MRS study of intraventricular tumors

Shah

Jayasundar

Singh

et al. 2011

Magnetic Resonance Imaging

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“…The explanation for the lack of NAA signal lies in the cell lines of origin for almost all primary and secondary brain tumors, which do not express the biosynthetic enzyme for NAA, Asp-NAT (see section 2.1. below). Interestingly, central neurocytoma (a rare neuronal tumor accounting for less than 0.5% of CNS tumors) have been reported by some investigators to exhibit detectable NAA levels, but reduced NAA/Cr (Chuang et al, 2005;Jayasundar et al, 2003). Hypothalamic hamartomas are benign congenital malformations that are disorganized in cytological architecture, and can contain predominantly glial or neuronal populations.…”

Section: Magnetic Resonance Spectroscopy and Imaging Of Naamentioning

confidence: 99%

N-Acetylaspartate in the CNS: From neurodiagnostics to neurobiology

Moffett

Ross

Arun

et al. 2007

Progress in Neurobiology

1,208

1,126

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The brain is unique among organs in many respects, including its mechanisms of lipid synthesis and energy production. The nervous system-specific metabolite N-acetylaspartate (NAA), which is synthesized from aspartate and acetyl-coenzyme A in neurons, appears to be a key link in these distinct biochemical features of CNS metabolism. During early postnatal CNS development, the expression of lipogenic enzymes in oligodendrocytes, including the NAA-degrading enzyme aspartoacylase (ASPA), is increased along with increased NAA production in neurons. NAA is transported from neurons to the cytoplasm of oligodendrocytes, where ASPA cleaves the acetate moiety for use in fatty acid and steroid synthesis. The fatty acids and steroids produced then go on to be used as building blocks for myelin lipid synthesis. Mutations in the gene for ASPA result in the fatal leukodystrophy Canavan disease, for which there is currently no effective treatment. Once postnatal myelination is completed, NAA may continue to be involved in myelin lipid turnover in adults, but it also appears to adopt other roles, including a bioenergetic role in neuronal mitochondria. NAA and ATP metabolism appear to be linked indirectly, whereby acetylation of aspartate may facilitate its removal from neuronal mitochondria, thus favoring conversion of glutamate to alpha ketoglutarate which can enter the tricarboxylic acid cycle for energy production. In its role as a mechanism for enhancing mitochondrial energy production from glutamate, NAA is in a key position to act as a magnetic resonance spectroscopy marker for neuronal health, viability and number. Evidence suggests that NAA is a direct precursor for the enzymatic synthesis of the neuron specific dipeptide N-acetylaspartylglutamate, the most concentrated neuropeptide in the human brain. Other proposed roles for NAA include neuronal osmoregulation and axon-glial signaling. We propose that NAA may also be involved in brain nitrogen balance. Further research will be required to more fully understand the biochemical functions served by NAA in CNS development and activity, and additional functions are likely to be discovered.

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“…More recently, proton magnetic resonance spectroscopy (MRS) of central neurocytomas has been reported. Typical patterns include elevated choline, decreased creatine, and NAA [16,17,36,37,38,41].…”

Section: Radiologymentioning

confidence: 99%

Central neurocytoma: A clinical, radiological and pathological study of nine cases

Chen¹,

Shen²,

Wang³

et al. 2008

Clinical Neurology and Neurosurgery

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Purpose-Central neurocytoma is a rare intraventricular brain tumor that affects young adults and presents with increased intracranial pressure secondary to obstructive hydrocephalus. Typically, it has a favorable prognosis after adequate surgical intervention, but in some cases the clinical course is more aggressive. In this report, we describe the diagnosis and treatment of central neurocytoma in a series of patients at our institution.Patients and Methods-Our series of nine patients (M:F=2:7, mean age, 28.2 years) with ventricular tumors showed typical radiological, histologic and immunohistochemical features of central neurocytoma. Most patients received craniotomy with removal of the tumor through transcallosal or transcortical approach. The surgical and histopathologic data of these patients were reviewed and analyzed.Results-The prognosis is generally favorable. Although most patients were alive and well at the last follow-up, two developed recurrence. Typical histologic features of recurrent neurocytoma include high proliferative activity (MIB-1 labeling index: 2.0-6.8%), prominent vascular proliferation and remarkable synaptophysin expression. Two patients (non-recurrent) died during follow-up due to sepsis or central failure. The MIB-1 labeling indices were as high as 2.2-5.4% for these two patients.Conclusion-Although central neurocytoma is generally a benign neoplasm, some variant forms of recurrence are also present. Complete resection provides favorable long-term prognosis in most cases. Recurrent tumors are often local and the patients seem to recover well after a second resection followed by radiotherapy. Histologic features such as tumor proliferation (MIB-1 labeling index), vascular proliferation, and synaptophysin expression are often prominent in the recurrent tumor. We recommend that these histologic features be considered for tumor recurrence during treatment and follow-up of these patients.

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In vivo and in vitro MR spectroscopic profile of central neurocytomas

Cited by 33 publications

References 16 publications

In vivo MRS study of intraventricular tumors

In vivo MRS study of intraventricular tumors

N-Acetylaspartate in the CNS: From neurodiagnostics to neurobiology

Central neurocytoma: A clinical, radiological and pathological study of nine cases

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