In Vivo and in Vitro Chromosomal Damage Induced by LSD-25

Phenothiazines and Chromosome Damage

“…A similar observation was first noted by Cohen et al (1967), when a series of experiments were made concerning LSD users and two types of controls:…”

“…The mean number of breaks encountered in these investigations was 10.2 per cent. This is higher than the reported values which show a range of 3.9 to 9.03 per cent (Cohen et al 1967, Nichols et al Egozcue et al 1968.…”

“…They were seen in normal human cultures (Lubs and Samuelson 1967) and none were seen in in vivo cultures derived from indi viduals exposed to chlorpromazine (Cohen et al 1967).…”

The Effect of LSD-25 on the Chromosomes of Children Exposed in Utero

“…21]. Additionally, an increase in chromosomal breakage in peripheral leukocytes of users of LSD has also Materials and Methods been observed by several investigators [11,15,20,36]. During these studies, preliminary evidence of trans-The mother-child pairs, both of the subject and of the placental passage suggested that chromosomal damage control groups, were volunteers from a middle class background and all had completed varying levels of college education.…”

“…to the developing human fetus might be observed following maternal ingestion of LSD during pregnancy The ability of the hallucinogen, lysergic acid diethyl- [11,15,36]. Therefore, additional children exposed to amide , to induce chromosomal damage in LSD during various times of gestation were investihuman leukocytes has been demonstrated in vitro [10, gated.…”