In vivo and in vitro study of a novel nanohydroxyapatite sonocoated scaffolds for enhanced bone regeneration

Rogowska-Tylman, Julia; Ločs, Jānis; Šalma, Ilze; Woźniak, Bartosz; Pilmane, Māra; Zālīte, Vita; Wojnarowicz, Jacek; Kędzierska-Sar, Aleksandra; Chudoba, Tadeusz; Szlązak, Karol; Chlanda, Adrian; Święszkowski, Wojciech; Gedanken, Aharon; Łojkowski, Witold

doi:10.1016/j.msec.2019.01.084

Cited by 56 publications

(40 citation statements)

References 80 publications

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“…Gedanken et al is one of the more active researcher in materials' sonochemical functionalization. In his research, mostly nanoparticles of Ag, Au, ZnO were used to enhance biological properties of materials for medical applications (Petkova et al, ; Rogowska‐Tylman et al, ; Salat et al, ; Svirinovsky et al, ). All those studies proved that sonochemical functionalization is a valuable and efficient tool for surface coating.…”

Section: Introductionmentioning

confidence: 99%

Sonochemical coating as an effective method of polymeric nonwovens functionalization

Kołbuk

Urbanek

Denis

et al. 2019

J Biomedical Materials Res

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A surface of polymeric nonwovens may be coated with various types of nanoparticles for medical applications, filtration, and so forth. However, quite often methods used for surface modification are difficult to scale up or are not applicable for polymers. In this article, we present one-step process enabling nonwovens functionalization. Poly (L-lactide-co-glicolide) (PLGA) nonwovens were prepared by electrospinning process and coated with hydroxyapatite nanoparticles (HAp) using ultrasonic processing. The effect of the process was evaluated with various techniques. HAp layer was successfully attached without loss of structural properties of HAp or PLGA nonwovens. The analysis confirmed the decrease of hydrophobicity of coated nonwoven, as well as its biocompatibility, making this material valuable from the perspective of medical applications. The sonochemical functionalization of polymeric nonwovens may be considered as an effective and economic method, enhancing surface properties of electrospun nonwovens for various applications.

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Section: Introductionmentioning

confidence: 99%

Sonochemical coating as an effective method of polymeric nonwovens functionalization

Kołbuk

Urbanek

Denis

et al. 2019

J Biomedical Materials Res

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“…Nanotechnology enables the application of nanomaterials to create innovative products, devices, and complex systems that make use of material properties in the nano-scale [ 11 ]. Products developed and created thanks to the use of nanotechnology are present in all aspects related to the human activity on Earth and in the outer space [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 ]. The current research concerning the applications of nanotechnology in the broadly understood catalysis, optoelectronics, microelectronics, biomedicine and pharmacy concentrate on the control of the physicochemical properties of nanostructures (NSs) [ 68 , 69 ], including of the nano zinc oxide (ZnO) [ 70 ].…”

Section: Introductionmentioning

confidence: 99%

A Review of Microwave Synthesis of Zinc Oxide Nanomaterials: Reactants, Process Parameters and Morphologies

2020

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Zinc oxide (ZnO) is a multifunctional material due to its exceptional physicochemical properties and broad usefulness. The special properties resulting from the reduction of the material size from the macro scale to the nano scale has made the application of ZnO nanomaterials (ZnO NMs) more popular in numerous consumer products. In recent years, particular attention has been drawn to the development of various methods of ZnO NMs synthesis, which above all meet the requirements of the green chemistry approach. The application of the microwave heating technology when obtaining ZnO NMs enables the development of new methods of syntheses, which are characterised by, among others, the possibility to control the properties, repeatability, reproducibility, short synthesis duration, low price, purity, and fulfilment of the eco-friendly approach criterion. The dynamic development of materials engineering is the reason why it is necessary to obtain ZnO NMs with strictly defined properties. The present review aims to discuss the state of the art regarding the microwave synthesis of undoped and doped ZnO NMs. The first part of the review presents the properties of ZnO and new applications of ZnO NMs. Subsequently, the properties of microwave heating are discussed and compared with conventional heating and areas of application are presented. The final part of the paper presents reactants, parameters of processes, and the morphology of products, with a division of the microwave synthesis of ZnO NMs into three primary groups, namely hydrothermal, solvothermal, and hybrid methods.

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“…With such fascinating properties, hydroxyapatite nanoparticles have shown many efforts in the delivery of drug and therapeutic agents with prolonged release [34][35][36][37][38][39]. Hydroxyapatite nanoparticles (HAPs) are of great interest in biomedical applications, such as bone regeneration [40,41]. Though HAPs have many applications as vehicles, especially in anticancer therapy, they have not yet designed DDSs for important prodrugs for cancers through active targeting.…”

Section: Introductionmentioning

confidence: 99%

Effective Targeting of Colon Cancer Cells with Piperine Natural Anticancer Prodrug Using Functionalized Clusters of Hydroxyapatite Nanoparticles

et al. 2020

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Targeted drug delivery offers great opportunities for treating cancer. Here, we developed a novel anticancer targeted delivery system for piperine (Pip), an alkaloid prodrug derived from black pepper that exhibits anticancer effects. The tailored delivery system comprises aggregated hydroxyapatite nanoparticles (HAPs) functionalized with phosphonate groups (HAP-Ps). Pip was loaded into HAPs and HAP-Ps at pH 7.2 and 9.3 to obtain nanoformulations. The nanoformulations were characterized using several techniques and the release kinetics and anticancer effects investigated in vitro. The Pip loading capacity was >20%. Prolonged release was observed with kinetics dependent on pH, surface modification, and coating. The nanoformulations fully inhibited monolayer HCT116 colon cancer cells compared to Caco2 colon cancer and MCF7 breast cancer cells after 72 h, whereas free Pip had a weaker effect. The nanoformulations inhibited ~60% in HCT116 spheroids compared to free Pip. The Pip-loaded nanoparticles were also coated with gum Arabic and functionalized with folic acid as a targeting ligand. These functionalized nanoformulations had the lowest cytotoxicity towards normal WI-38 fibroblast cells. These preliminary findings suggest that the targeted delivery system comprising HAP aggregates loaded with Pip, coated with gum Arabic, and functionalized with folic acid are a potentially efficient agent against colon cancer.

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In vivo and in vitro study of a novel nanohydroxyapatite sonocoated scaffolds for enhanced bone regeneration

Cited by 56 publications

References 80 publications

Sonochemical coating as an effective method of polymeric nonwovens functionalization

Sonochemical coating as an effective method of polymeric nonwovens functionalization

A Review of Microwave Synthesis of Zinc Oxide Nanomaterials: Reactants, Process Parameters and Morphologies

Effective Targeting of Colon Cancer Cells with Piperine Natural Anticancer Prodrug Using Functionalized Clusters of Hydroxyapatite Nanoparticles

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