In vivo and in vitro assessment of the action of SN 28049, a benzonaphthyridine derivative targeting topoisomerase II, on the murine Colon 38 carcinoma

Abstract

The superior antitumour activity of SN 28049 may result from its ability to induce long term cycle arrest. Host immune responses contribute to the curative activity of SN 28049 and this could result from the induction of cycle arrest.

Contemporary Challenges in the Design of Topoisomerase II Inhibitors for Cancer Chemotherapy

“…Its action is however complex, implicating poisoning of topoisomerase IIα, suppression of topoisomerase I, and inhibition of SP-1-regulated genes . This topoisomerase II poison has shown excellent antitumor activities in a melanoma xenograft model and in a murine model of colon adenocarcinoma, with a superior activity when compared to etoposide . A selective uptake and retention of SN28049 in the tumor was recently characterized …”