In vivo and in vitro cytogenetic effects of the anti-tumor agent amsacrina (AMSA)

Biological activity in Macrocystis pyrifera from Argentina: sodium alginate, fucoidan and laminaran. II. Genotoxicity

“…It has been shown that antitumor drugs can have genotoxic effects at therapeutic dosages (Larripa et al, 1984). In order to establish if genetic damage was caused at the dosage at which the in vivo and in vitro antitumor effect was seen with the crude dialyzed extracts of MP, we studied the genotoxic effect of the crude extract of Macrocystis pyrifera as well as that of sodium alginate, fucoidan and laminaran, both in vivo and in vitro, using the bonemarrow micronucleus (Schmid, 1975) and anaphase-telophase (Nichols et al, 1972) tests, respectively.…”

The bone marrow micronucleus test and metronidazole genotoxicity in different strains of mice (Mus musculus)

“…Since the 1980s our research team has used experimental designs based on the micronucleus test using the CFW mouse strain (Larripa et al, 1984(Larripa et al, , 1992Mudry et al, 1987Mudry et al, , 1994 and established an historical mean number of micronuclei for untreated control CFW mice of 9.73 ± 2.53 micronuclei per 1000 polychromatic erythrocytes, the addition of the data from the present study altering this mean value to 9.13 ± 2.58 micronuclei per 1000 polychromatic erythrocytes for this strain.…”