Biological activity in Macrocystis pyrifera from Argentina: sodium alginate, fucoidan and laminaran. II. Genotoxicity

Biological activity in Macrocystis pyrifera from Argentina: sodium alginate, fucoidan and laminaran. I. Antitumor, cytotoxicity and humoral immune response

“…Thus these studies and those reported elsewhere (Larripa et al, 1987) on the nature of the biological activity in CDE of MP may provide a rational explanation for our earlier observations, as well as the efficacy of the long standing folk-medicinal use of brown algae for cancer treatment in China and Japan (Stein & Borden, 1984). The in vivo antitumor and in vitro cytotoxic effects initially observed (Mayer & Panick, 1982) may well be the result of a complex interaction of metals, algal polysaccharides and the physiological response of the host.…”

Organometallic Complexes with Biological Molecules: VIII. Synthesis, Solid State andin vivo Investigation of Triorganotin(IV) Derivatives ofL-Homocysteic Acid

“…All of these effects may lead to inaccurate distribution of chromosomes between daughter nuclei, resulting in cells with chromosomal numbers that deviate from the normal diploid complement. Identical conclusions have been reached using bone-marrow micronucleus tests after treatment with the crude extract of Macrocystis pyrifera, 42 two continuous cell lines, rainbow trout gonad (RTG-2) and bluegill fry (BF-2) following exposure to four polycyclic aromatic hydrocarbons (PAH), aromatic amine, one nitrosamide and one fungal toxine, 43 and early developing embryos of Anilocra physodes (Crustacea, Isopoda) following exposure to bis[dimethyltin(IV)chloro] protoporphyrin IX. 44 As suggested in a previous report, 45 the present data imply that the cytotoxic alterations, involving embryos at early stages of development, are also related to chromosomal disorders, mainly resulting in structural alterations of the chromosomes and/or inhibition of mitotic spindle, this latter presumably through a modification of the chemical structure of the tubulin.…”

Re‐evaluation of alginic acid and its sodium, potassium, ammonium and calcium salts (E 400–E 404) as food additives

“…A chromosome aberration test with sodium alginate was also performed with Chinese hamster ovary cells (Larripa et al., ) without S9 metabolic activation and no clastogenic effects were detected. However, no data were given about the cytotoxicity and the sodium alginate was tested only up to 0.1 mg/mL which is well below the maximum dose level of 2 mg/mL recommended in current Organisation for Economic Co‐operation and Development (OECD) guideline No 413.…”