In vitro wound healing evaluation, antioxidant and chemical profiling of Baeckea frutescens leaves ethanolic extract

Kamarazaman, Ihsan Safwan; Ali, Nor Azah Mohamad; Abdullah, Fauziah; Saad, Nazrin Che; Ali, Aida; Ramli, Salfarina; Rojsitthisak, Pornchai; Halim, Hasseri

doi:10.1016/j.arabjc.2022.103871

Cited by 10 publications

(20 citation statements)

References 36 publications

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“…Kamarazaman et al [ 56 ] evaluated the wound healing effect of the ethanolic extract obtained from Baeckea frutescens leaves. In this study, a HaCat and BJ cell line were exposed to different concentrations of an ethanolic extract from B. frutescens , and the cell migration rate was determined.…”

Section: In Vitro Studies On the Effect Of Natural Products On Wound ...mentioning

confidence: 99%

Wound Healing Properties of Natural Products: Mechanisms of Action

et al. 2023

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A wound is the loss of the normal integrity, structure, and functions of the skin due to a physical, chemical, or mechanical agent. Wound repair consists of an orderly and complex process divided into four phases: coagulation, inflammation, proliferation, and remodeling. The potential of natural products in the treatment of wounds has been reported in numerous studies, emphasizing those with antioxidant, anti-inflammatory, and antimicrobial properties, e.g., alkaloids, saponins, terpenes, essential oils, and polyphenols from different plant sources, since these compounds can interact in the various stages of the wound healing process. This review addresses the most current in vitro and in vivo studies on the wound healing potential of natural products, as well as the main mechanisms involved in this activity. We observed sufficient evidence of the activity of these compounds in the treatment of wounds; however, we also found that there is no consensus on the effective concentrations in which the natural products exert this activity. For this reason, it is important to work on establishing optimal treatment doses, as well as an appropriate route of administration. In addition, more research should be carried out to discover the possible side effects and the behavior of natural products in clinical trials.

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Section: In Vitro Studies On the Effect Of Natural Products On Wound ...mentioning

confidence: 99%

Wound Healing Properties of Natural Products: Mechanisms of Action

et al. 2023

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“…In this section, the outcomes of phytochemical investigations of B frutescens are based on the use of column chromatography (CC) to isolate purified compounds and LC-MS analysis to detect compounds in plant extracts. A list of isolates is summarized in Table 1 and Figures 1 to 3, including phloroglucinols 1-14 , 3,13,14,20,21 phloroglucinol-based meroterpenoids 15-61 , 17,20,22–26 sesquiterpenoids 62-65 , 3,27 triterpenoids 66-68 , 3,12 flavonoids 69-102 , 5–13,21,24,28–32 chromones 103-121 , 9,12,28,30,33,34 5-membered ring compounds 122-126 , 2,21 mono -phenol 127 , 12 and phytosterol 128 . 12 In addition, the names of these isolates have been ordered in an alphabetic arrangement.…”

Section: Phytochemistrymentioning

confidence: 99%

“…Flavonoids are low-molecular-weight phenolic compounds that are found in a variety of higher plants. 35–37 As shown in Table 1 and Figure 2, flavonoids derived from B frutescens can be divided into flavones 69-94 5–11,28–30,32 and flavanones 95-102 . 9,12,13,21,24,29,31…”

Section: Phytochemistrymentioning

confidence: 99%

“…35–37 As shown in Table 1 and Figure 2, flavonoids derived from B frutescens can be divided into flavones 69-94 5–11,28–30,32 and flavanones 95-102 . 9,12,13,21,24,29,31…”

Section: Phytochemistrymentioning

confidence: 99%

“…32 6- C -Methylquercetin ( 85 ) is a well-known compound, 8,9,28,29,32 but its 7- O- β-D-glucopyranoside ( 86 ) was a new flavone separated from the aerial part. 28 Likewise, myricetin ( 89 ) 9,29 and myricitrin ( 91 ) 9,30,32 are 2 well-known plant constituents, but myricetin 3- O -(5″- O -galloyl)-α-L-arabinofuranoside ( 90 ) was isolated by CC and then identified by LC-MS from the aerial part for the first time. 28,29 In the last case, by either CC or LC-MS procedures, quercetin ( 92 ), its 3- O -α-L-rhamnoside ( 93 ), and 3- O -(5″- O -galloyl)-α-L-arabinofuranoside ( 94 ) were confirmed to be present in the aerial part.…”

Section: Phytochemistrymentioning

confidence: 99%

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Baeckea frutescensL.: A Review on Phytochemistry, Biosynthesis, Synthesis, and Pharmacology

Hương

Duc

Son

2023

Natural Product Communications

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Background In traditional medicine of Southeast Asian countries, Baeckea frutescens L. (family Myrtaceae) has a long history of use. Numerous research projects have shown that this plant contains metabolites with remarkable medicinal value. No review document, to date, has given an insight into the role of B frutescens constituents in pharmacological development. Objective The current review briefly offers crucial information on the phytochemistry, biosynthesis, synthesis, and pharmacology of B frutescens. Methods B frutescens is the most meaningful keyword to search for literature data. It was used either on its own or in combination with other keywords. References have been gathered from various resources such as Google Scholar, SciFinder, and PubMed. More than 50 electronic references were collected from the 1960s. Results Approximately 130 metabolites have been isolated and structurally determined from this medicinal plant. They included phloroglucinols, phloroglucinol-based meroterpenoids, sesquiterpenoids, triterpenoids, flavonoids, chromones, 5-membered ring compounds, and others. B frutescens fresh tissues were thought to be a rich resource of essential oils. Tasmanone is a precursor in the biosynthesis of various B frutescens compounds, while phloroglucinol derivatives can be seen as initial compounds in the synthetic procedures of various B frutescens molecules. B frutescens plant extracts and compounds isolated from them possess a variety of pharmacological properties, such as cytotoxic, antimicrobial, anti-inflammatory, antioxidant, antirheumatoid, skin protective, and mosquito larvicidal activities. Conclusion More experimental reports on phytochemistry and pharmacology are required. In vivo pharmacological studies on the mechanisms of action of the active compounds are urgently required since most of the results obtained so far have been from in vitro assays.

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In Vitro Evaluation of Anti-Angiogenic Efficacy, Cell Migration Activity and Cell Survival Effect Against Hydrogen Peroxide-Induced Damage of Prunetin

KARAYILDIRIM

2023

Pharm Chem J

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In vitro wound healing evaluation, antioxidant and chemical profiling of Baeckea frutescens leaves ethanolic extract

Cited by 10 publications

References 36 publications

Wound Healing Properties of Natural Products: Mechanisms of Action

Wound Healing Properties of Natural Products: Mechanisms of Action

Baeckea frutescensL.: A Review on Phytochemistry, Biosynthesis, Synthesis, and Pharmacology

In Vitro Evaluation of Anti-Angiogenic Efficacy, Cell Migration Activity and Cell Survival Effect Against Hydrogen Peroxide-Induced Damage of Prunetin

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