In vitro/vivo evaluation of novel mitochondrial targeting charge-reversal polysaccharide-based antitumor nanoparticle

Fang, Lei; Lin, Hua; Wu, Zhenfeng; Wang, Zhen; Fan, Xinxin; Cheng, Ziting; Hou, Xiaoya; Chen, Daquan

doi:10.1016/j.carbpol.2020.115930

Cited by 55 publications

(20 citation statements)

References 41 publications

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“… 25 , 29 Although the average zeta potential of the PFP-NDs was 73.7 mV ( Table 1 ), the excess positive charge on the nanoparticles might affect its in vivo stability and blood circulation. 30 With the electrostatic bonding of LucDNA to the cationic PFP-NDs, the binary nanoparticles PFP-BNDs were formulated. The surface zeta potential of PFP-BNDs decreased slightly owing to the neutralization of the negatively charged LucDNA, while the diameter of PFP-BNDs was increased because of the loose electrostatic interaction between them.…”

Section: Resultsmentioning

confidence: 99%

“…The particle size distribution measured by DLS illustrated that the diameters were approximately 340 nm and exhibited a narrow distribution (Figure B). A particle size less than 400 nm was necessary for the efficient delivery of the NDs into tissues through the enhanced permeability and retention effect. , Although the average zeta potential of the PFP-NDs was 73.7 mV (Table ), the excess positive charge on the nanoparticles might affect its in vivo stability and blood circulation . With the electrostatic bonding of LucDNA to the cationic PFP-NDs, the binary nanoparticles PFP-BNDs were formulated.…”

Section: Resultsmentioning

confidence: 99%

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Ultrasound-Aided Targeting Nanoparticles Loaded with miR-181b for Anti-Inflammatory Treatment of TNF-α-Stimulated Endothelial Cells

Liu

et al. 2020

ACS Omega

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Gene therapy is an emerging therapeutic strategy used in clinics. Ultrasound-mediated gene transfection possesses great potential as a secure and available approach for gene delivery. However, transfection efficiency and targeting ability remain challenging. In this study, we developed a kind of ultrasound-aided and targeting nanoparticles for microRNA delivery. These nanoparticles carrying nucleic acids were prepared with cationic poly-(amino acid) encapsulated with perfluoropentane. The formulated nanoparticles were stabilized with negatively charged PGA–PEG–RGD peptide coating. Ultrasound imaging and specific gene transfection using this nanocarrier could be implemented simultaneously. Upon treatment with ultrasound irradiation, phase transition was induced in the nanoparticles and they generated acoustic cavitation, resulting in enhanced gene transfection against the endothelial cells. With the overexpression of miR-181b loaded by the nanoparticles, the TNF-α-stimulated endothelial cells were effectively rescued from the inflammatory state through the protection of cell viability and suppression of cell adhesion.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Ultrasound-Aided Targeting Nanoparticles Loaded with miR-181b for Anti-Inflammatory Treatment of TNF-α-Stimulated Endothelial Cells

Liu

et al. 2020

ACS Omega

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“…After entering into the tumor cells, the lysosomes escaped successfully, and more Cur was transmitted to the mitochondria. The results of in vivo experiments showed that the core–shell nanoparticles efficiently delivered the drug to the tumor site and significantly prolonged the retention time of the drug in the tumor tissue [ 83 ].…”

Section: Enhancement Of Water Solubility Stability and Permeability Of The Drugmentioning

confidence: 99%

A review on the applications of Traditional Chinese medicine polysaccharides in drug delivery systems

Wang

Xiong

et al. 2022

Chin Med

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Traditional Chinese medicine polysaccharides (TCMPs) are plentiful and renewable resources with properties such as biocompatibility, hydrophilicity, biodegradability, and low cytotoxicity. Because the polysaccharide molecular chain contains a variety of active groups, different polysaccharide derivatives can be easily produced through chemical modification. They have been increasingly used in drug delivery systems (DDS). However, the potential of polysaccharides is usually ignored due to their structural complexity, poor stability or ambiguity of mechanisms of actions. This review summarized the applications of TCMPs in DDS around four main aspects. The general characteristics of TCMPs as drug delivery carriers, as well as the relationships between structure and function of them were summarized. Meanwhile, the direction of preparing multifunctional drug delivery materials with synergistic effect by using TCMPs was discussed. This review aims to become a reference for further research of TCMPs and their derivatives, especially applications of them as carriers in pharmaceutical preparation industry.

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“…Different from the preparation of CT/PTX, the carrier material of FT/PTX is a mixture of FTT and FTVE, and the mass ratio of FTT to FTVE is 4:1. The cytotoxicity of CT/PTX and FT/PTX nanoparticles against A549 was determined by MTT assay [37,38]. A549 cells were respectively plated in 96-well plates.…”

Section: In Vitro Cytotoxicity Assaysmentioning

confidence: 99%

Novel ROS-responsive marine biomaterial fucoidan nanocarriers with AIE effect and chemodynamic therapy

Guo

Cheng

et al. 2022

International Journal of Biological Macromolecules

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Chemodynamic therapy (CDT) has been widely used in the treatment of many kinds of tumors, which can effectively induce tumor cell apoptosis by using produced reactive oxygen species (ROS). In this paper, ROS-sensitive multifunctional marine biomaterial natural polysaccharide nanoparticles (CT/PTX) were designed. Aggregation-induced emission (AIE) molecules tetraphenylethylene (TPE) labeled and caffeic acid (CA) modi ed fucoidan (FUC) amphiphilic carrier material (CA-FUC-TK-TPE, CFTT) was fabricated, in which the thioketal bond was used as the linkage arm between TPE and fucoidan chain, giving the CFTT material ROS sensitivity. In addition, amphiphilic carrier material (FUC-TK-VE, FTVE) composed of thioketal-linked vitamin E and fucoidan was synthesized. The mixed carrier material CFTT and FTVE selfassembled in water to form nanoparticles (CT/PTX ) loaded with PTX and Fe 3+ . CT/PTX nanoparticles could induce ROS oxidative stress in tumor sites through the CDT effect induced by Fe 3+ . The CDT effect was combined with the chemotherapeutic drug PTX to achieve tumor inhibition. In vitro cell studies have proved that CT/PTX nanoparticles have excellent cell permeability and tumor cytotoxicity. In vivo antitumor experiments con rmed effective antitumor activity and reduced side effects.

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In vitro/vivo evaluation of novel mitochondrial targeting charge-reversal polysaccharide-based antitumor nanoparticle

Cited by 55 publications

References 41 publications

Ultrasound-Aided Targeting Nanoparticles Loaded with miR-181b for Anti-Inflammatory Treatment of TNF-α-Stimulated Endothelial Cells

Ultrasound-Aided Targeting Nanoparticles Loaded with miR-181b for Anti-Inflammatory Treatment of TNF-α-Stimulated Endothelial Cells

A review on the applications of Traditional Chinese medicine polysaccharides in drug delivery systems

Novel ROS-responsive marine biomaterial fucoidan nanocarriers with AIE effect and chemodynamic therapy

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