Novel ROS-responsive marine biomaterial fucoidan nanocarriers with AIE effect and chemodynamic therapy

Abstract

Chemodynamic therapy (CDT) has been widely used in the treatment of many kinds of tumors, which can effectively induce tumor cell apoptosis by using produced reactive oxygen species (ROS). In this paper, ROS-sensitive multifunctional marine biomaterial natural polysaccharide nanoparticles (CT/PTX) were designed. Aggregation-induced emission (AIE) molecules tetraphenylethylene (TPE) labeled and caffeic acid (CA) modi ed fucoidan (FUC) amphiphilic carrier material (CA-FUC-TK-TPE, CFTT) was fabricated, in which the thioketal bond was used as the linkage arm between TPE and fucoidan chain, giving the CFTT material ROS sensitivity. In addition, amphiphilic carrier material (FUC-TK-VE, FTVE) composed of thioketal-linked vitamin E and fucoidan was synthesized. The mixed carrier material CFTT and FTVE selfassembled in water to form nanoparticles (CT/PTX ) loaded with PTX and Fe 3+ . CT/PTX nanoparticles could induce ROS oxidative stress in tumor sites through the CDT effect induced by Fe 3+ . The CDT effect was combined with the chemotherapeutic drug PTX to achieve tumor inhibition. In vitro cell studies have proved that CT/PTX nanoparticles have excellent cell permeability and tumor cytotoxicity. In vivo antitumor experiments con rmed effective antitumor activity and reduced side effects.

All-in-One Alkaline Phosphatase-Response Aggregation-Induced Emission Probe for Cancer Discriminative Imaging and Combinational Chemodynamic–Photodynamic Therapy

“…The integration of two or more forms of treatment has been proposed as an alternative approach to improve cancer therapeutic efficiency, − which can produce synergistic effects through cooperative interactions and complementation among several types of monotherapies, resulting in a much stronger therapeutic effect when compared to each individual therapeutic model. Chemodynamic therapy (CDT), as an emerging approach for noninvasive tumor therapy, has achieved outstanding performances in numerous biomedical researches and clinical trials through an intratumoral Fenton/Fenton-like reaction that can generate highly toxic ROS. − CDT stands out as a light- and oxygen-independent modality in contrast to other ROS-mediated cancer therapies like PDT. This unique characteristic allows CDT to overcome penetration depth restrictions, making it versatile and exhibiting a universal therapeutic effect even in hypoxic tumors.…”