In vitro-Untersuchungen zur Chlorpromazine (CPZ)-Photoallergie

Eg, Jung

doi:10.1007/bf00641879

Cited by 9 publications

(2 citation statements)

References 11 publications

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“…This process has been studied in in uitro systems. Three photoallergic compounds have been demonstrated to covalently bond to protein upon photoexcitation, namely TCSA (Herman and Sams, 1971;Kochevar and Harber, 1977), chlorpromazine (Jung, 1970) and Jadit (Jung et al, 1968). The type of species which actually reacts with skin proteins to form the antigen has not clearly been determined in any of these cases and may vary between compounds.…”

Section: Photochemical Reaction With Proteinmentioning

confidence: 99%

Photoallergic Responses to Chemicals

Kochevar

1979

Photochem & Photobiology

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Abstract— –Photochemical and immunologic knowledge about photoallergy to chemicals is briefly summarized. Studies in in vitro systems have demonstrated that photoallergic compounds can covalently bond to proteins through a photochemical reaction. The immunologic nature of the photoallergic response is based mainly on clinical observations, induction of photoallergy in man and in guinea‐pigs and on results of in vitro immunologic tests. Studies of the photoreactions of the photoallergic compound, 3,3′,4′,5‐tetrachlorosalicylanilide (TCSA), with proteins are discussed. TCSA noncovalently bonds to human serum albumin prior to irradiation. Prior interaction is essential for formation of a photoaddition product indicating that a short‐lived reactive species derived from TCSA is involved in the photoaddition and limiting the number of skin proteins which can participate in antigen formation. By fragmentation of the TCSA‐albumin photoadduct with CNBr, it was determined that TCSA can bond to at least three sites on the albumin molecule. TCSA also can sensitize the photooxidation of histidine in albumin.

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Section: Photochemical Reaction With Proteinmentioning

confidence: 99%

Photoallergic Responses to Chemicals

Kochevar

1979

Photochem & Photobiology

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“…Schwarz (23,24) and Jung (11,12,13) have experimentally produced a so-called inverse photo allergy with sulfanilamides and chlorpromazine, whereby the skin is irradiated immediately before application of the photosensitizing agent. Tims, the irradiation energy may be stored in the skin and could be supplied afterwards to the photo• sensitizing agent.…”

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confidence: 99%