In-vitro-Untersuchungen über den Fettstoffwechsel isolierter menschlicher Fettzellen in Abhängigkeit von der Zellgröße: Die durch Adrenalin induzierte Lipolyse.

Jd, Faulhaber; En, Petruzzi; Eble, H; Ditschuneit, H

doi:10.1055/s-0028-1095157

Cited by 47 publications

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“…4. Correlation between relative body weight and adipocyte volume in maturity onset-diabetics cedure leads to values which were never exceeded by our measurements, and, as far as can be seen, in the literature [7,8,13,14]. There are several reasons for the statement of a maximum adipocyte size, e.g.…”

Section: Discussionsupporting

confidence: 73%

“…In the other extreme, Martinsson [17] only found the adipocyte number, but not the adipoeyte size, correlated with the weight index. A distinction between hypertrophy and hyperplasia of the adipose tissue is of great practical importance, since there exists a positive correlation between adipocyte volume and basal lipolysis [8,13,18]. Elevated serum concentrations of free fatty acids in obesity cause a metabolic situation which promotes the manifestation of maturity onset-diabetes [19--21].…”

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confidence: 99%

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Human adipocyte volumes: Maximum size, and correlation to weight index in maturity onset-diabetes

Leonhardt¹,

Hanefeld²,

Schneider³

et al. 1972

Diabetologia

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Adipocytes of man and rat were isolated by incubation with collagenase. Their size distributions were measured with the pulse counter ZG 2 and evaluated on a lognormal base. Empirically, we have found that the standard deviations of the distributions are negatively correlated with the cell diameter. By extrapolation of the standard deviations to zero, we calculated upper limits of the adipoeyte volumes to be Vm ~ 0.93 nl (subcutaneous adipose tissue of the abdomen in man) and Vm ~ 0.49 nl (epididymal and retroperitoneal adipose tissue in white wistar rats). Larger adipocyte volumes in these tissues have not been observed. --The correlations between adipocyte volume v and relative body weight m/m o have been measured in non-diabetics (I) and maturity onsetdiabetics (II) separately: m/m o ~ 2.34 v + 0.45 (I), and m/m o ~-0.576 v + 0.95 (iI). The regression coefficients in both equations are significantly different: adipocyte volumes increase more directly with weight index in maturity onset-diabetics. Supposing that overweight is an excess of adipocyte mass, we have derived a general relation between weight index m/me, adipocyte volume v and N/m o, the adipocyte number per kg body mass: m/mo~0.93 Nv/mo+0.79. It follows with the abovementioned regression coefficients that obese maturity onset-diabetics have smaller adipoeyte numbers than obese non-diabetics. This means that the predisposition to maturity onset-diabetes is extreme in those obese persons who got their overweight after the end of adolescence. Volume des cellules adipeuses chez l'homme: taille maxim.ttm et correlation avec l'index de poids dans le diab~te de l' dge meetR~sum~. Chez l'homme et le rat, des cellules adlpeuses ont dr6 isoldes par incubation avec la collagdnase. Les rdpartitions d'apr@s leur taille ont 6t4 faites ~ l'aide du compteur ~ impulsions ZG 2 et 6valu6es sur une base lognormale. De fagon empirique, nous avons trouv6 quc les d@viations standard dans les r@partitions sent en corrdlation n6gative avee le diam@tro des cellules. Par extrapolation des ddviations standard an z6ro, nous avons calcul6 les limites sup6rieures du volume des cellules adipeuses de Vm ~ 0.93 nl (tissu adipeux souscutan6 do l'abdomen chez l'homme) et Vm= 0.49 nl (tissu adipeux 6pididymaire et r6trop6riton@al ehez le rat blanc Wistar). Des volumes plus grands de cellules adipeuses n'ont pas 6td observ@s dans ces tissus. Les corr@lations entre le volume v des cellules adipeuses et le poids corporel relatif m/m o ont gt6 mesurdes s6par~ment chez des non-diab@tiques (I) et chez des malades avee diabSte dtabli tardivement (II) : m/m o = 2.34 v + 0.45 (I), et m/m o ~ 0.576 v + 0.95 (II). Les coefficients de r6gwession dans les deux 6quations sent diffdrents de far significative: Its volumes des cellules adipeuses augmentent plus fortement avec l'index de poids chez les malades avec diab~te 6tabli tardivement. Si nous supposons que l'exc~s de poids est un execs de la masse des cellules adipeuses, nous avons une relation gdndrale entre l'index de poids m/m o, le volume v ...

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Section: Discussionsupporting

confidence: 73%

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confidence: 99%

Human adipocyte volumes: Maximum size, and correlation to weight index in maturity onset-diabetes

Leonhardt¹,

Hanefeld²,

Schneider³

et al. 1972

Diabetologia

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“…Calculations. The average lipid content of the single fat cell was calculated according to Faulhaber [4], using the follo~ng formula From the lipid content of the single fat cell and the EFA content of the tissue, the cell number was calculated.…”

Section: Methodsmentioning

confidence: 99%

Effect of weight and cell size on hormone-induced lipolysis in New Zealand obese mice and American obese hyperglycemic micce

Herberg

Gries

1970

Diabetologia

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“…Plasma glycerol and FFA concentration were not changed by physical training. It has previously been shown that there is a correlation between cell size and lipolysis in uitro (Faulhaber et al 1969, Smith 1970, Goldrick and McLoughlin 1970, Bjorntorp and Sjostrom 1972. The fact that the glycerol and FFA levels were not changed in spite of the reduced adipose mass because of smaller fat cells may indicate enhanced lipolysis in these smaller fat cells as suggested by other authors (Froberg et al 1972, Askew et al 1973.…”

Section: Discussionmentioning

confidence: 63%

The Effects of Physical Exercise on Fat Cell Metabolism in the Rat

Kral

Jacobsson

Smith

et al. 1974

Acta Physiologica Scandinavica

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In-vitro-Untersuchungen über den Fettstoffwechsel isolierter menschlicher Fettzellen in Abhängigkeit von der Zellgröße: Die durch Adrenalin induzierte Lipolyse.

Cited by 47 publications

References 0 publications

Human adipocyte volumes: Maximum size, and correlation to weight index in maturity onset-diabetes

Human adipocyte volumes: Maximum size, and correlation to weight index in maturity onset-diabetes

Effect of weight and cell size on hormone-induced lipolysis in New Zealand obese mice and American obese hyperglycemic micce

The Effects of Physical Exercise on Fat Cell Metabolism in the Rat

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