In-vitro thrombogenicity assessment of polymer filament modified and native platinum embolic coils

Girdhar, Gaurav; Read, Megan; Sohn, JiHae; Shah, Chirag; Shrivastava, Sandeep

doi:10.1016/j.jns.2014.01.030

Cited by 14 publications

(22 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on the results of the study, in the setting where acute occlusion is important, it would appear that fibers have an advantage over non-fibered coils. This observation validates prior studies in this area (12)(13)(14). Barth et al (12), using a swine renal artery model, showed that bare metal coils resulted in no occlusion and that coils with wool, silk, and Ivalon resulted in immediate and, in that model, sustained occlusion at 3 months.…”

Section: Discussionsupporting

confidence: 87%

“…Further, blinding was used to eliminate any bias in the study on the part of the operator. The results confirm prior research, which showed that the addition of fibers to coils increases their immediate thrombogenicity and results in fewer embolic devices and presumably a faster time to occlusion (12)(13)(14). The actual time to occlusion could not be determined exactly in the study because of the nature of the study; in other words, a set time was allowed to pass after deployment of each coil to check for occlusion.…”

Section: Discussionsupporting

confidence: 79%

“…Although there has been an explosion of coil technology, including detachable devices, hydrogel-coated devices, and other enhancements, there continues to be controversy as to whether fibers on coils are beneficial. Very early literature suggested that such fibers are beneficial; however, the level of evidentiary support for fibers remains limited (12,13). In addition, the nature of the both the coil material and the fiber material used in earlier studies does not necessarily match that of current devices.…”

Section: Discussionmentioning

confidence: 99%

“…Histologic analysis showed less inflammation in the silk and Ivalon groups than wool. Girdhar et al (13) used an in vitro model to demonstrate increased thrombogenicity of nylon-and poly(glycolide-co-L-lactide)fibered platinum coils over non-fibered ones, with nylon being the more thrombogenic of the 2. Liebig et al (14) showed higher occlusion rates in cerebral aneurysms using fibered compared to non-fibered coils.…”

Section: Discussionmentioning

confidence: 99%

“…The recognition of recanalization in coiled vessels has rekindled an old argument as to the value of fibers on embolization coils. There is scant literature addressing this question (12)(13)(14), and older literature compared devices that are no longer on the market, such as wool-, silk-or Ivalon-fibered stainless steel coils (12). The present study sought to inform the fibered versus non-fibered discussion in coil embolotherapy, specifically to determine the relative acute effectiveness in embolization as well as intermediate-term recanalization for modern platinum embolization coils, both with and without nylon fibers.…”

mentioning

confidence: 98%

See 4 more Smart Citations

Nylon Fibered Versus Non-Fibered Embolization Coils: Comparison in a Swine Model

Trerotola

Pressler

Premanandan

2019

Journal of Vascular and Interventional Radiology

View full text Add to dashboard Cite

Purpose: To determine whether nylon fibers improve the performance of platinum embolization coils in porcine arteries. Materials and Methods: Platinum 0.035" embolization coils, both with and without nylon fibers, were used to embolize a total of 24 hindlimb arteries in 6 swine: 12 with fibered coils and 12 with non-fibered coils. Apart from fibers, the coils were identical. Immediate and late results were studied, including number of coils needed to achieve vessel occlusion and durability of occlusion at 1 and 3 months. Arteriographic as well as histopathologic analysis were performed. Results: A mean of 3.2 (range, 2-4) non-fibered coils was required to achieve occlusion, whereas a mean of 1.3 (range, 1-2) fibered coils achieved occlusion in similarly sized arteries (2.3-3.2-mm diameter, P < .001). The mean percent cross-sectional area occupied by thrombus was greater in arteries with fibered coils than with non-fibered coils at 1 month (63% ± 6% and 48% ± 15%, respectively, P ¼ .03) but not at 3 months (61% ± 6% and 49% ± 15%, respectively, P ¼ .06). Some recanalization was observed at follow-up and did not differ between groups at 1 month (P ¼ .07) or 3 months (P ¼ .22). Conclusions: Nylon fibers allow significantly fewer embolization coils to achieve acute occlusion of arteries compared to bare metal coils. Both fibered and non-fibered coils showed recanalization at follow-up.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 98%

See 3 more Smart Citations

Nylon Fibered Versus Non-Fibered Embolization Coils: Comparison in a Swine Model

Trerotola

Pressler

Premanandan

2019

Journal of Vascular and Interventional Radiology

View full text Add to dashboard Cite

show abstract

Single Component Polymers, Polymer Blends, and Polymer Composites for Interventional Endovascular Embolization of Intracranial Aneurysms

Karadeli,

Kuram

2023

Macromolecular Bioscience

View full text Add to dashboard Cite

Intracranial aneurysm is the abnormal focal dilation in brain arteries. When untreated, it can enlarge to rupture points and account for subarachnoid hemorrhage cases. Intracranial aneurysms can be treated by blocking the flow of blood to the aneurysm sac with clipping of the aneurysm neck or endovascular embolization with embolics to promote the formation of the thrombus. Coils or an embolic device are inserted endovascularly into the aneurysm via a micro‐catheter to fill the aneurysm. Many embolization materials have been developed. An embolization coil made of soft and thin platinum wire called the “Guglielmi detachable coil” (GDC) enables safer treatment for brain aneurysms. However, patients may experience aneurysm recurrence because of incomplete coil filling or compaction over time. Unsatisfactory recanalization rates and incomplete occlusion are the drawbacks of endovascular embolization. So, the fabrication of new medical devices with less invasive surgical techniques is mandatory to enhance the long‐term therapeutic performance of existing endovascular procedures. For this aim, the current article reviews polymeric materials including blends and composites employed for embolization of intracranial aneurysms. Polymeric materials used in embolic agents, their advantages and challenges, results of the strategies used to overcome treatment, and results of clinical experiences are summarized and discussed.

show abstract

FairEmbo Concept for Arterial Embolizations: In Vivo Feasibility and Safety Study with Suture-Based Microparticles Compared with Microspheres

Bisceglie

Hak

Diop

et al. 2020

Cardiovasc Intervent Radiol

View full text Add to dashboard Cite

Purpose: Microspheres are effective embolic agents especially for the management of bleeding and oncologic lesions. The first FairEmbo study reported the effectiveness of embolization using suture fragments. The effectiveness and safety of arterial embolization with Suture-Based Microparticles (SBM) were assessed in a swine model. Materials and methods:In this ethical-approved animal study, a polar artery in each kidney was embolized in four swine: one side with hand-cut non-absorbable SBM (Flexocrin 2 ® ) and the contralateral side with Embozene ® 900 for comparison. Swine were followed for 3 months (M3) to evaluate the effectiveness and the safety of SBM.Follow-up protocol included clinical monitoring, computed tomography (CT) control and digital subtraction angiography (DSA), followed by histological analyses. The SBM confection parameters were evaluated by automatic microscopic sizer. RStudio software and Mann-Whitney test (significance at P<0.05) were used for statistics. Results:The average size of SBM was 1002μm (SD=258). All targets were effectively embolized by SBM, with an angiogram defect estimated at 45.6% (95% CI [35.9-55.2]), compared to 40.5% (95% CI [30.6-55.5]) for Embozene ® group, without significant difference (P=0.342). The average duration of SBM embolization procedure was significantly increased compared to Embozene ® embolization (1202s versus 222s, P=0.029). There were no statistical differences in M3 DSA and CT for SBM and Embozene ® , with persistence of partial arterial occlusion and atrophic embolized area. No postoperative complications were observed on clinical and CT controls. Conclusion:This experimental study suggests that embolization with SBM is safe and effective in short and medium-term follow-up as compared to microspheres.

show abstract

In-vitro thrombogenicity assessment of polymer filament modified and native platinum embolic coils

Cited by 14 publications

References 26 publications

Nylon Fibered Versus Non-Fibered Embolization Coils: Comparison in a Swine Model

Nylon Fibered Versus Non-Fibered Embolization Coils: Comparison in a Swine Model

Single Component Polymers, Polymer Blends, and Polymer Composites for Interventional Endovascular Embolization of Intracranial Aneurysms

FairEmbo Concept for Arterial Embolizations: In Vivo Feasibility and Safety Study with Suture-Based Microparticles Compared with Microspheres

Contact Info

Product

Resources

About