In Vitro Susceptibility of Methicillin-Resistant
            <i>Staphylococcus aureus</i>
            and Methicillin-Susceptible
            <i>Staphylococcus aureus</i>
            to a New Antimicrobial, Copper Silicate

Carson, Kerry C.; Bartlett, J.G.; Tan, Trina-Jean; Riley, Thomas V.

doi:10.1128/aac.00771-07

Cited by 18 publications

(9 citation statements)

References 15 publications

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“…This is worrying as copper resistance mechanisms have been shown to be important for the virulence of P. aeruginosa (Schwan et al ., 2005) and M. tuberculosis (Ward et al ., 2010). In addition soluble and metallic surface copper is increasingly being used as an antibacterial (McLean et al ., 1993; Carson et al ., 2007; Ruparelia et al ., 2008; Casey et al ., 2010). There is already evidence that chromosomal encoded copper resistance mechanisms play a role in survival on metallic copper surfaces (Elguindi et al ., 2009) with possibly other novel mechanisms also playing an important role (Santo et al ., 2010).…”

Section: Discussionmentioning

confidence: 99%

The Staphylococcus aureus CsoR regulates both chromosomal and plasmid‐encoded copper resistance mechanisms

Baker

Sengupta

Jayaswal

et al. 2011

Environmental Microbiology

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Copper is an essential metal which is used as a cofactor in several enzymes and is required for numerous essential biochemical reactions. However, free copper ions can be toxic to cellular systems if the intracellular concentration is not tightly regulated. In this study we show that Staphylococcus aureus copper resistance is not the same in every staphylococcal isolate, but in fact varies considerably between clinical strains. Hyper-copper-resistance was shown to be due to the carriage of an additional plasmid-encoded copper homeostasis mechanism, copBmco. This plasmid can be transferred into the copper-sensitive S. aureus Newman to confer a hyper-copper-resistant phenotype, showing that copper resistance has the potential to spread to other S. aureus strains. This is the first time that plasmid-encoded copper resistance has been reported and shown to be transferable between pathogenic bacteria isolated from humans. A homologue of the Bacillus subtilis and Mycobacterium tuberculosis CsoR regulators was identified in S. aureus. The S. aureus csoR gene is conserved in all sequenced S. aureus genomes and was found to be copper-induced and transcribed along with two downstream genes: a putative copper chaperone (csoZ) and a hypothetical gene. Mutational and complementation studies showed that unlike other homologues, the S. aureus CsoR negatively regulates both chromosomal and plasmid-encoded copper homeostasis mechanisms in response to excess-copper conditions.

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Section: Discussionmentioning

confidence: 99%

The Staphylococcus aureus CsoR regulates both chromosomal and plasmid‐encoded copper resistance mechanisms

Baker

Sengupta

Jayaswal

et al. 2011

Environmental Microbiology

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“…This encouraged the EPA to register nearly 300 copper surfaces as antimicrobial products for cleaning and disinfection applications. − There has been a surge in patents granted on antimicrobial coatings of copper and research activities in the past 20 years. On further investigation, it has been found that copper has an excellent efficacy against a range of pathogenic microorganisms such as Gram-positive bacteria such as S. aureus , − Clostridium difficile , ,, and B. subtili , Gram-negative bacteria such as E. coli , ,,, P. aeruginosa , and Legionella pneumophila , and viruses. Motivated by the superior antimicrobial properties of copper, it finds applications in numerous ways in our life right from the construction sector to the healthcare sector for preventing infections in hospitals.…”

Section: Antibacterial and Antiviral Properties Of Nanomaterialsmentioning

confidence: 99%

Antibacterial and Antiviral Functional Materials: Chemistry and Biological Activity toward Tackling COVID-19-like Pandemics

Balasubramaniam

Prateek

Ranjan

et al. 2020

ACS Pharmacol. Transl. Sci.

199

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The ongoing worldwide pandemic due to COVID-19 has created awareness toward ensuring best practices to avoid the spread of microorganisms. In this regard, the research on creating a surface which destroys or inhibits the adherence of microbial/viral entities has gained renewed interest. Although many research reports are available on the antibacterial materials or coatings, there is a relatively small amount of data available on the use of antiviral materials. However, with more research geared toward this area, new information is being added to the literature every day. The combination of antibacterial and antiviral chemical entities represents a potentially path-breaking intervention to mitigate the spread of disease-causing agents. In this review, we have surveyed antibacterial and antiviral materials of various classes such as small-molecule organics, synthetic and biodegradable polymers, silver, TiO2, and copper-derived chemicals. The surface protection mechanisms of the materials against the pathogen colonies are discussed in detail, which highlights the key differences that could determine the parameters that would govern the future development of advanced antibacterial and antiviral materials and surfaces.

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“…Cu and/or its compounds have been investigated for antimarine biofouling applications , as well as for their efficacy against a spectrum of pathogenic microorganisms such as Gram-positive bacteria (e.g., Staphylococcus aureus (S. aureus), − Clostridium difficile (C. difficile), ,, Bacillus subtilis ), Gram-negative bacteria (e.g., Escherichia coli (E.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Copper-Based Materials and Coatings: Potential Multifaceted Biomedical Applications

Mitra

Kang

Neoh

2019

ACS Appl. Mater. Interfaces

197

109

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Surface contamination by microbes leads to several detrimental consequences like hospital- and device-associated infections. One measure to inhibit surface contamination is to confer the surfaces with antimicrobial properties. Copper’s antimicrobial properties have been known since ancient times, and the recent resurgence in exploiting copper for application as antimicrobial materials or coatings is motivated by the growing concern about antibiotic resistance and the pressure to reduce antibiotic use. Copper, unlike silver, demonstrates rapid and high microbicidal efficacy against pathogens that are in close contact under ambient indoor conditions, which enhances its range of applicability. This review highlights the mechanisms behind copper’s potent antimicrobial property, the design and fabrication of different copper-based antimicrobial materials and coatings comprising metallic copper/copper alloys, copper nanoparticles or ions, and their potential for practical applications. Finally, as the antimicrobial coatings market is expected to grow, we offer our perspectives on the implications of increased copper release into the environment and the potential ecotoxicity effects and possibility of development of resistant genes in pathogens.

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In Vitro Susceptibility of Methicillin-Resistant Staphylococcus aureus and Methicillin-Susceptible Staphylococcus aureus to a New Antimicrobial, Copper Silicate

Cited by 18 publications

References 15 publications

The Staphylococcus aureus CsoR regulates both chromosomal and plasmid‐encoded copper resistance mechanisms

The Staphylococcus aureus CsoR regulates both chromosomal and plasmid‐encoded copper resistance mechanisms

Antibacterial and Antiviral Functional Materials: Chemistry and Biological Activity toward Tackling COVID-19-like Pandemics

Antimicrobial Copper-Based Materials and Coatings: Potential Multifaceted Biomedical Applications

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