In vitro study on the degradation of lithium-doped hydroxyapatite for bone tissue engineering scaffold

Wang, Yaping; Xu, Yang; Gu, Zhipeng; Qin, Huanhuan; Li, Li; Liu, Jingwang; Yu, Xixun

doi:10.1016/j.msec.2016.04.065

Cited by 85 publications

(50 citation statements)

References 42 publications

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“…Therefore, when lithium is substituted into the HA structure, it plays an important role because it could induce a decrease in HA solubility [53,54], without affecting its biocompatibility [55,56], and an improvement of biomechanical properties, without altering the HA structure. The reason for the increase of strength of lithium doped HA may be due to the fact that metal ions could decrease the porosity of samples which can result in a more compact and hard structure [57]. Also, one notes that, as a substituted trace element, lithium can positively influence the viability [58], proliferation rates and alkaline phosphatase activity of cells [59,60].…”

Section: Biocompatibilitymentioning

confidence: 99%

“…Also, one notes that, as a substituted trace element, lithium can positively influence the viability [58], proliferation rates and alkaline phosphatase activity of cells [59,60]. Wang et al [57] reported that when used in a proper low dose (0.5% and 1%), lithium ions can substitute calcium ones in a HA structure, in order to obtain a biomaterial (LiHA scaffold) characterized by high strength, a higher osteoblast-mediated degradation rate and a superior ability to promote cell proliferation as compared to simple HA and controls. On one hand, the lithium incorporation into HA can change the surface topography of original HA material and make LiHA scaffold possess a more compact bulk, which finally can result in a higher adherence and enhanced growth of osteoblasts [61].…”

Section: Biocompatibilitymentioning

confidence: 99%

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Pulsed Laser Deposited Biocompatible Lithium-Doped Hydroxyapatite Coatings with Antimicrobial Activity

et al. 2019

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Simple and lithium-doped biological-origin hydroxyapatite layers were synthesized by Pulsed Laser Deposition technique on medical grade Ti substrates. Cytotoxic effects of lithium addition and the biocompatibility of obtained coatings were assessed using three cell lines of human origin (new initiated dermal fibroblasts, immortalized keratinocytes HaCaT, and MG-63 osteosarcoma). Antimicrobial properties of obtained coatings were assessed on two strains (i.e., Staphylococcus aureus and Candida albicans), belonging to species representative for the etiology of medical devices biofilm-associated infections. Our findings suggest that synthesized lithium-doped coatings exhibited low cytotoxicity on human osteosarcoma and skin cells and therefore, an excellent biocompatibility, correlated with a long-lasting anti-staphylococcal and -fungal biofilm activity. Along with low fabrication costs generated by sustainable resources, these biological-derived materials demonstrate their promising potential for future prospective solutions—viable alternatives to commercially available biomimetic HA implants—for the fabrication of a new generation of implant coatings.

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Section: Biocompatibilitymentioning

confidence: 99%

Section: Biocompatibilitymentioning

confidence: 99%

Pulsed Laser Deposited Biocompatible Lithium-Doped Hydroxyapatite Coatings with Antimicrobial Activity

et al. 2019

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“…The SBF was prepared using the Kokubo method [24]. Inorganic aqueous solution (pH = 7.4) with ion concentration near human blood plasma was used [25]. Scaffolds with different contents of nHAp were soaked in SBF and kept at 37 • C. The ratio of scaffold surface area to SBF volume was kept at 1 cm 2 to 10 mL.…”

Section: Sbf Immersionmentioning

confidence: 99%

Tunable Degradation Rate and Favorable Bioactivity of Porous Calcium Sulfate Scaffolds by Introducing Nano-Hydroxyapatite

Zhou

Yuan

Peng³

et al. 2016

Applied Sciences

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The bone scaffolds should possess suitable physicochemical properties and osteogenic activities. In this study, porous calcium sulfate (CaSO 4 ) scaffolds were fabricated successfully via selected laser sintering (SLS). Nano-hydroxyapatite (nHAp), a bioactive material with a low degradation rate, was introduced into CaSO 4 scaffolds to overcome the overquick absorption. The results demonstrated that nHAp could not only control the degradation rate of scaffolds by adjusting their content, but also improve the pH environment by alleviating the acidification progress during the degradation of CaSO 4 scaffolds. Moreover, the improved scaffolds were covered completely with the apatite spherulites in simulated body fluid (SBF), showing their favorable bioactivity. In addition, the compression strength and fracture toughness were distinctly enhanced, which could be ascribed to large specific area of nHAp and the corresponding stress transfer.

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“…Hydroxyapatite (HA) is well known as a bioactive ceramic added to many artificial bone tissues and implants for orthopedic surgeries [14][15][16]. Not only polymer/HA composites exhibit the chemical and mechanical stability of natural bones [17,18], but also they can be designed in the form of porous materials that accelerate the circulation of essential biochemical agents such as VD 3 [19].…”

Section: Introductionmentioning

confidence: 99%

Effect of HA Nanoparticles on Adsorption of Vitamin D3 on Super-Hydrophobic PA6 Nanofibrous Scaffold

Esfahani

Ghiyasi

2020

Matéria (Rio J.)

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Vitamin D 3 has significant roles in bone growth and the prevention of osteoporotic fractures. The present study investigated the effect of hydroxyapatite nanoparticles decoration onto polyamide-6 nanofibrous scaffold on adsorption behaviour of Vitamin D 3. To synthesize the nanofibrous scaffold, an electrospinning device was used, and the surface of the scaffold was characterized by scanning electron microscopy, energy dispersive spectrometry, Fourier transform infrared spectroscopy, and measurement of the water contact angle. The antibacterial activity test against E. coli and S. aureus bacteria indicated no such activity of pristine and hydroxyapatite decorated scaffold. The results demonstrated that a hydrophobic and high porous scaffold was formed, and hydroxyapatite nanoparticles were distributed inside the polyamide-6 nanofibers homogenously. Results showed that the hydroxyapatite nanoparticles improved the adsorption efficiency of polyamide-6 scaffold. It was found that the amount of adsorbed Vitamin D 3 molecules onto the polyamide-6/HA scaffold was rapid during the first hour of immersion (24.4 ng.cm-3), then declined over the next 3 h, and eventually reached a stable percentage of about 10.3 ng.cm-3. This phenomenon appears to be related to the high adsorption potential of porosities and the hydrophobic nanofibers during the first stage of immersion and non-occupied hydroxyapatite ceramic sites during the final stage of immersion.

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In vitro study on the degradation of lithium-doped hydroxyapatite for bone tissue engineering scaffold

Cited by 85 publications

References 42 publications

Pulsed Laser Deposited Biocompatible Lithium-Doped Hydroxyapatite Coatings with Antimicrobial Activity

Pulsed Laser Deposited Biocompatible Lithium-Doped Hydroxyapatite Coatings with Antimicrobial Activity

Tunable Degradation Rate and Favorable Bioactivity of Porous Calcium Sulfate Scaffolds by Introducing Nano-Hydroxyapatite

Effect of HA Nanoparticles on Adsorption of Vitamin D3 on Super-Hydrophobic PA6 Nanofibrous Scaffold

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