In vitro study of the antioxidant properties of non steroidal anti-inflammatory drugs by chemiluminescence and electron spin resonance (ESR)

Mouithys-Mickalad, A.; Shao-xiong, Zheng; Deby‐Dupont, G.; Deby, C.; Lamy, Maurice; Reginster, Jean‐Yves; Henrotin, Yves

doi:10.1080/10715760000301131

Cited by 58 publications

(37 citation statements)

References 36 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nimesulide, like some classical NSAIDs exhibits a considerable degree of anti-infl ammatory activity as a consequence of various inhibitory effects on polymorphonuclear neutrophil leucocytes (PMNs) (Dallegri et al, 1990(Dallegri et al, , 1992a(Dallegri et al, , 1992bOttonello et al, 1992Ottonello et al, , 1993Ottonello et al, , 1995Ottonello et al, , 1999Capecchi et al, 1993;Verhoeven et al, 1993;Bevilacqua et al, 1994;Dapino et al, 1994;Tool and Verhoeven, 1995;Bennett and Villa, 2000;Bennett, 2001;Mouithys-Mickalad et al, 2000;Nakatani et al, 2001;Gomez-Gaviro et al, 2002;Bravo-Cuellar et al, 2003;Kimura et al, 2003;Rainsford et al, 2005). These effects are, in some cases, relatively potent compared with the activities of other NSAIDs, and occur within the drug concentrations in plasma or synovial fl uids encountered during therapy with the drug Bennett and Villa, 2000;Bennett, 2001).…”

Section: Cox-2 and Anti-infl Ammatory Activitymentioning

confidence: 97%

Current status of the therapeutic uses and actions of the preferential cyclo-oxygenase-2 NSAID, nimesulide

Rainsford

2006

Inflammopharmacol

View full text Add to dashboard Cite

This review summarizes the principal therapeutic responses to the preferential COX-2 NSAID, nimesulide, in treating musculo-skeletal joint symptoms and various acute and chronic pain conditions and the mode of action in relation to therapy in these states. In extensive studies in laboratory animal models and clinical trails in patients nimesulide has been found to have potent analgesic, anti-inflammatory and anti-pyretic activities. It is approved for use in over 50 countries worldwide (including those in the EU, South and Central America, China, India and some other South-East Asia) for the treatment of acute pain, the symptomatic treatment of painful osteoarthritis and primary dysmenorrhoea. Its mode of action in these states is related to the preferential inhibition of the production of cyclo-oxygenase-2 (COX-2) and other inflammatory mediators whose production is controlled by stimulation of cyclic-3 ,5'-adenosine monophosphate (cAMP); this means that nimesulide is a multi-factorial drug in controlling inflammation and pain. The adverse reaction profile of nimesulide is, in general, like that of other NSAIDs. It does, however, have relatively low occurrence of gastro-intestinal (GI) side effects which is related to its low propensity to inhibit the physiologically important COX-1 in the GI mucosa and important physicochemical properties (high pKa of 6.5 and lipophilicity) as well as inhibiting of mast cell derived histamine and acid secretion in the stomach. In contrast with the coxibs, nimesulide has not been found to have appreciable cardiovascular toxicity.

show abstract

Section: Cox-2 and Anti-infl Ammatory Activitymentioning

confidence: 97%

Current status of the therapeutic uses and actions of the preferential cyclo-oxygenase-2 NSAID, nimesulide

Rainsford

2006

Inflammopharmacol

View full text Add to dashboard Cite

show abstract

“…Most related studies have used human PMN (Neal et al 1987;Parij et al 1998;Mouithys-Mickalad et al 2000;Abdullah et al 2001) in which a number of non-steroidal anti-inflammatory drugs (NSAIDs) were found effective in modulating PMN oxidative activity (Van Dyke et al 1982;Neumuller and Tohidast-Akrad 1994). The direct effects of NSAIDs on ex-vivo isolated equine neutrophils have not been fully investigated, especially in relation to their oxidative activity.…”

Section: Introductionmentioning

confidence: 96%

Modulatory effects of non-steroidal anti-inflammatory drugs on the luminol and lucigenin amplified chemiluminescence of equine neutrophils

et al. 2011

View full text Add to dashboard Cite

The purpose of this study was to explore the potential modulation of equine neutrophil oxidative burst by a series of classical NSAIDs which was subsequently monitored by the luminol or lucigenin-enhanced chemiluminescence (CL) technique. A significant dose-dependent inhibition of the luminol CL was observed with the majority of investigated drugs. This inhibition was very significant for phenylbutazone and Indomethacin; while for aspirin, a higher concentration is required. The action of Ketoprofen was significant during the first 5 min and only when the concentration was above 1 mM. Indomethacin and acetylsalicylic acid result in an inhibition dose-dependent of luminol CL. On the other hand, the phenylbutazone showed an inhibiting effect when used either luminol or lucigenin though luminol is slightly better. When the ketoprofen is considered, an inhibiting effect of luminal CL was observed but less significant than the other NSAIDs investigated. The flunixin meglumine enhances strongly the CL.

show abstract

“…Chemiluminescence measures the total oxidant activity produced by the reaction of the oxidant species with the chemiluminescent probe. The possible reaction between probe and drug is not excluded, leading to the attribution of a pro-oxidant effect [16,17]. Diclofenac, isoxicam, zomepirac and valeryl aalycilate exhibited the same pronounced concentration-dependent O 2 .À scavenging activities (Figure 2a and 2b).…”

Section: O 2 à Radical Scavenging Effectmentioning

confidence: 86%

Reactivity of Biologically Important NSAID Compounds with Superoxide (O₂^.−), nitric oxide (^.NO) and Cyclooxygenase Inhibition

et al. 2007

View full text Add to dashboard Cite

In the present study, we investigated the free radical-scavenging effects of eight Nonsteroidal Anti-Inflammatory Drugs (NSAID) using a Superoxide (O 2 .À ) and Nitric Oxide ( . NO) generating system in vitro. Indomethacine showed higher scavenging activity against O 2 .À , it being more potent than ibuprofen and nimesulide at the same concentration. Diclofenac showed a more relevant effect on the .NO scavenging activity than against O 2 .À . Comparison of the activities of eight compounds showed that the aryl-acetic compounds have higher scavenging activities than the diarylheterocyclic ones. We have also found that the O 2 scavenging activity correlates with the Next-Highest-Occupied pOrbital (NHOMO) levels and the Next-Lowest-Unoccupied p-Orbital (NLUMO)-NHOMO gaps correlate with Cyclooxygenase-1 (COX-1) inhibitory activity. These results suggest that both NHOMO and NHOMO-NLUMO gap energies can be of predictive value in the search for new candidate anti-inflammatory drugs.

show abstract

In vitro study of the antioxidant properties of non steroidal anti-inflammatory drugs by chemiluminescence and electron spin resonance (ESR)

Abstract: The NSAIDs possess variable degrees of antioxidant activities, linked to their ability to react with HOCl, lipid peroxides or ONOO-. These antioxidant activities could offer interesting targeted side-effects in the treatment of joint inflammatory diseases.

Cited by 58 publications

References 36 publications

Current status of the therapeutic uses and actions of the preferential cyclo-oxygenase-2 NSAID, nimesulide

Current status of the therapeutic uses and actions of the preferential cyclo-oxygenase-2 NSAID, nimesulide

Modulatory effects of non-steroidal anti-inflammatory drugs on the luminol and lucigenin amplified chemiluminescence of equine neutrophils

Reactivity of Biologically Important NSAID Compounds with Superoxide (O₂^.−), nitric oxide (^.NO) and Cyclooxygenase Inhibition

Contact Info

Product

Resources

About

In vitro study of the antioxidant properties of non steroidal anti-inflammatory drugs by chemiluminescence and electron spin resonance (ESR)

Abstract: The NSAIDs possess variable degrees of antioxidant activities, linked to their ability to react with HOCl, lipid peroxides or ONOO-. These antioxidant activities could offer interesting targeted side-effects in the treatment of joint inflammatory diseases.

Cited by 58 publications

References 36 publications

Current status of the therapeutic uses and actions of the preferential cyclo-oxygenase-2 NSAID, nimesulide

Current status of the therapeutic uses and actions of the preferential cyclo-oxygenase-2 NSAID, nimesulide

Modulatory effects of non-steroidal anti-inflammatory drugs on the luminol and lucigenin amplified chemiluminescence of equine neutrophils

Reactivity of Biologically Important NSAID Compounds with Superoxide (O2.−), nitric oxide (.NO) and Cyclooxygenase Inhibition

Contact Info

Product

Resources

About

Reactivity of Biologically Important NSAID Compounds with Superoxide (O₂^.−), nitric oxide (^.NO) and Cyclooxygenase Inhibition