In vitro study of the specific interaction between poly(2-dimethylamino ethylmethacrylate) based polymers with platelets and red blood cells

Flebus, Luca; Lombart, François; Martínez-Jothar, Lucía; Sevrin, Chantal; Delierneux, Céline; Oury, Cécile; Grandfils, Christian

doi:10.1016/j.ijpharm.2015.06.036

Cited by 3 publications

(1 citation statement)

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“…It has been shown that, just like E-selectin, P-selectin appears on the surface of endothelial cells under the influence of the cytokines IL-1 and TNF. It has been established that when platelets are activated, P-selectin also appears in whole blood (Flebus et al, 2015). In addition, P-selectin expression is known to be significantly increased by platelet activation during hypertension (Liu et al, 2016).…”

Section: P-selectin and Its Role In Hemostasismentioning

confidence: 99%

Role of P-Selectin in the Development of Hemostasis Disorders in COVID-19

Golubeva

2022

Biol Bull Rev

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This is a review of data on the impact of COVID-19 on blood clotting. An important feature of the pathogenesis of severe acute respiratory syndrome caused by the SARS-Co-2 coronavirus is the risk of thrombotic complications including microvascular thrombosis, venous thromboembolism, and stroke. These thrombotic complications, like thrombocytopenia, are markers of the severe form of COVID-19 and are associated with multiple organ failure and increased mortality. One of the central mechanisms of this pathology is dysregulation of the adhesive protein P-selectin. The study of the mechanisms of changes in hemostasis and vascular pathology, and the role in these processes of biomarkers of thrombogenesis, and primarily of P-selectin of various origins (platelets, endothelial cells, and plasma), can bring some clarity to the understanding of the pathogenesis and therapy of COVID-19.

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Section: P-selectin and Its Role In Hemostasismentioning

confidence: 99%