In vitro study of the hemocompatibility of superparamagnetic contrast agent for magnetic resonance imaging

Chouly, C.; Bordenave, Laurence; Bareille, Reine; Guérin, V.; Baquey, A.; Pouliquen, Daniel; Baquey, C.; Jallet, P.

doi:10.1016/0267-6605(94)90061-2

Cited by 31 publications

(16 citation statements)

References 16 publications

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“…These studies revealed that incubation of 70 nm magnetide/dextran particles with blood resulted in 60% hemolysis; however, this lytic activity was considered clinically irrelevant due to extremely high nanoparticle concentration used for the in vitro studies. Indeed, when clinically relevant doses of the magnetide/ dextran particles were applied, no hemolysis occurred (20). It is known that blood contact with negatively charged surfaces such as glass or kaolin often results in the contact phase activation of the plasma coagulation system (21,22).…”

Section: Discussionmentioning

confidence: 99%

Blood Compatibility of Cetyl Alcohol/Polysorbate-Based Nanoparticles

et al. 2005

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Section: Discussionmentioning

confidence: 99%

Blood Compatibility of Cetyl Alcohol/Polysorbate-Based Nanoparticles

et al. 2005

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“…40 To this end, RBC were incubated with free IR813 or NPs-COOH core for 2 h, and the hemolytic capacity was further assessed ( Figure 7A). …”

Section: Articlementioning

confidence: 99%

Surface Chemistry Architecture of Silica Nanoparticles Determine the Efficiency of in Vivo Fluorescence Lymph Node Mapping

et al. 2013

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Near-infrared (NIR) imaging of the lymphatic system offers a sensitive, versatile, and accurate lymph node mapping to locate the first, potentially metastatic, draining nodes in the operating room. Many luminescent nanoprobes have received great attention in this field, and the design of nontoxic and bright nanosystems is of crucial importance. Fluorescent NIR-emitting dye doped silica nanoparticles represent valuable platforms to fulfill these scopes, providing sufficient brightness, resistance to photobleaching, and hydrophilic nontoxic materials. Here, we synthesized these highly stable core-shell nanoparticles with a programmable surface charge positioning and determined the effect of these physicochemical properties on their in vivo behavior. In addition, we characterized their fluorescence kinetic profile in the right axillary lymph node (RALN) mapping. We found that nanoparticles with negative charges hidden by a PEG shell are more appropriate than those with external negative charges in the mapping of lymph nodes. We also demonstrated the efficient excretion of these nanostructures by the hepatobiliary route and their nontoxicity in mice up to 3 months postinjection. These results indicate the potential future development of these fluorescent nanosystems for LN mapping.

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“…Determination of hemolytic properties is one of the most common tests in studies of nanoparticle interaction with blood components [37][38][39]. Erythrocyte interaction with QDs is particularly important in the use of QDs for in vivo applications.…”

Section: Hemolysis Assay Of Cdte/zns Qdsmentioning

confidence: 99%