In Vitro Study of DP-bioglass Paste for Treatment of Dentin Hypersensitivity

Lee, Bor-Shiunn; Tsai, Hsin Yi; Tsai, Yao-Chen; Lan, Wan–Hong; Lin, Chang‐Ching

doi:10.4012/dmj.24.562

Cited by 35 publications

(32 citation statements)

References 27 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a previous study, we demonstrated that an occlusive depth of 10 m in dentinal tubules could be achieved Sol-gel bioglass for dentinal tubule occlusion 58 through the melting of bioglass with Nd:YAP laser irradiation 17) . Then, we further extended the occlusive depth to 60 m by the use of DP-bioglass paste 18) . However, for chemical reaction to persist and hence achieve a deep sealing depth, there must be sufficient ion supply from DP-bioglass by virtue of a continuous release of ions.…”

Section: Discussionmentioning

confidence: 99%

“…Group D represented the DPbioglass synthesized with conventional glass-melting method 18) and served as the control group. Raw materials and the weight amounts used are listed in Table 1.…”

Section: Synthesismentioning

confidence: 99%

“…In another study, we prepared DP-bioglass through melting of related oxide precursors at 1410℃ and mixed the DP-bioglass with 30％ phosphoric acid to produce homogeneous occlusion on exposed dentinal tubules and 60μm of sealing depth 18) . However, the DP-bioglass paste had to be placed on the dentinal surface for three days in …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

In Vitro Study of Dentinal Tubule Occlusion with Sol-gel DP-bioglass for Treatment of Dentin Hypersensitivity

et al. 2007

Self Cite

View full text Add to dashboard Cite

DP-bioglass paste has been demonstrated to produce 60 μm of sealing depth on exposed dentinal tubules. However, the occlusive effect depended on a continuous placement of DP-bioglass paste on dentinal surface for three days. In a bid to fabricate highly reactive DP-bioglass particles, a sol-gel method was used together with HNO3, NaOH, and H3PO4 as catalysts. As a result, the application time of DP-bioglass paste was significantly reduced to 10 minutes. Percentage of tubular occlusion with DP-bioglass was 53.2-65.4％, while One Coat Bond and Seal & Protect yielded 51.3％ and 41.2％ respectively. Further, the average depth of tubular occlusion with DP-bioglass was 55.8-62.7 μm, while One Coat Bond and Seal & Protect produced 40.8 μm and 32.5 μm respectively. In conclusion, the best sealing performance of tubular occlusion was rendered by DP-bioglass catalyzed with HNO3. Its performance was significantly better than Seal & Protect, and was considered to exhibit the greatest potential in treating dentin hypersensitivity.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Group D represented the DPbioglass synthesized with conventional glass-melting method 18) and served as the control group. Raw materials and the weight amounts used are listed in Table 1.…”

Section: Synthesismentioning

confidence: 99%

See 1 more Smart Citation

In Vitro Study of Dentinal Tubule Occlusion with Sol-gel DP-bioglass for Treatment of Dentin Hypersensitivity

et al. 2007

Self Cite

View full text Add to dashboard Cite

show abstract

“…Although these agents and products stated above were reported to be effective, their therapeutic effects were generally short-lived or diminished with time. This is because these occluding materials are easily removed by daily brushing, food chewing, and the consumption of acidic drinks 11) . To ensure sustained treatment effect, a novel material that produces a deeper sealing into the dentinal tubules needs to be developed.…”

Section: Introductionmentioning

confidence: 99%

“…They include light-cured bonding materials 5) , strontium chloride, sodium fluoride 6) , potassium nitrate and potassium oxalate 7) , silica 8) , calcium-based remineralizing agents [9][10][11][12] , and nanosized carbonate apatite 13) . Some dentin hypersensitivity treatment products contain a variety of chemical agents.…”

Section: Introductionmentioning

confidence: 99%

Effect of mesoporous silica nanoparticles on dentinal tubule occlusion: An in vitro study using SEM and image analysis

et al. 2014

View full text Add to dashboard Cite

Abrogation of the inflammatory response in LPS‐stimulated RAW 264.7 murine macrophages by Zn‐ and Cu‐doped bioactive sol–gel glasses

Varmette¹,

Nowalk

Flick

et al. 2008

J Biomedical Materials Res

View full text Add to dashboard Cite

The attenuation of an in vitro inflammatory response in RAW 264.7 murine macrophages stimulated with lipopolysaccharide (LPS) endotoxin was tested using sol-gel-derived bioactive glasses. Three general types of sol-gel-derived samples were evaluated: 58S, zinc-containing glasses, and copper-containing glasses. Distinct experimental procedures were used to test the potential of bioactive glasses to attenuate the inflammatory response in three situations: (1) therapeutically following LPS stimulation, (2) prophylactically before LPS stimulation of macrophages, and (3) indirectly via the glass dissolution products after stimulation with LPS. A sandwich enzyme-linked immunosorbent assay (ELISA) was used to monitor the concentration of tumor necrosis factor-alpha (TNF-alpha) secreted by macrophage cells. The strongest reduction in TNF-alpha concentration was observed when macrophage cells were first incubated with bioactive glass powder and then stimulated with LPS. This suggests a possible prophylactic application of these bioactive glasses for the prevention of inflammation. The 58S glass was capable of reducing the expression of TNF-alpha by macrophages, although the zinc- and copper-containing were more effective at suppressing the inflammatory response. The additional benefit of using zinc- and copper-doped bioactive glasses may be explained by the direct interactions of zinc and copper ions in key regulatory pathways for the inflammation response.

show abstract

In Vitro Study of DP-bioglass Paste for Treatment of Dentin Hypersensitivity

Cited by 35 publications

References 27 publications

In Vitro Study of Dentinal Tubule Occlusion with Sol-gel DP-bioglass for Treatment of Dentin Hypersensitivity

In Vitro Study of Dentinal Tubule Occlusion with Sol-gel DP-bioglass for Treatment of Dentin Hypersensitivity

Effect of mesoporous silica nanoparticles on dentinal tubule occlusion: An in vitro study using SEM and image analysis

Abrogation of the inflammatory response in LPS‐stimulated RAW 264.7 murine macrophages by Zn‐ and Cu‐doped bioactive sol–gel glasses

Contact Info

Product

Resources

About