In Vitro Study of Dentinal Tubule Occlusion with Sol-gel DP-bioglass for Treatment of Dentin Hypersensitivity

Lee, Bor-Shiunn; Kang, Shu-Han; Wang, Yin‐Lin; Lin, Feng‐Huei; Lin, Chun‐Pin

doi:10.4012/dmj.26.52

Cited by 44 publications

(41 citation statements)

References 23 publications

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“…During reaction, the pH value is also higher than MCPM. This results in a higher viscosity of the product, limiting the initial reaction product fluid dynamics of the slurries and decreasing the ability to flow smoothly into the dentinal tubules [15]. …”

Section: Discussionmentioning

confidence: 99%

“…This technique allows for high specific surface area of the mesoporous structure to be produced with the capability to carry drugs. Currently, different types of bioactive glass (BG) have been applied in dental science literature as well as dentin tubules occlusion [14,15,16]. The main ingredient of bioactive glass (BG) is SiO 2 –CaO–Na 2 O–P 2 O 5 .…”

Section: Introductionmentioning

confidence: 99%

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Phosphorus Effects of Mesoporous Bioactive Glass on Occlude Exposed Dentin

Chen

Kung

et al. 2013

Materials

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In recent studies, sealing of exposed dentinal tubules is generally considered as one of the most effective strategies to treat dentin hypersensitivity. Mesoporous bioactive glass (MBG) is a potential material for treating dentin hypersensitivity due to its highly specific areas for dissolution and re-precipitated reaction for reduction in dentin permeability. The groups of commercial products of PerioGlas®, synthetic MBG and MBG without phosphorus (MBGNP) were compared. The MBG and MBGNP powders were prepared by the sol-gel method and mixed with different calculated ratios of phosphoric acid (PA) and then was brushed onto dentin surfaces. We used X-ray diffractometer (XRD), scanning electronic microscope (SEM), and Fourier transform infrared spectroscopy (FTIR) to investigate the physiochemistry and the occlusion ability of dentinal tubules. The results showed that MBG paste mixed with PA solution has a better ability for occluding dentinal tubules than MBGNP; it has a short reaction time and good operability. The major crystallite phase of MBG agents was monocalcium phosphate monohydrate [Ca(H2PO4)2·H2O] in the early stages of the reactions. MBG pastes that were mixed with 30% and 40% PA had the ability to create excellent penetration depth greater than 80 μm. These agents have the potential to treat dentin hypersensitivity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phosphorus Effects of Mesoporous Bioactive Glass on Occlude Exposed Dentin

Chen

Kung

et al. 2013

Materials

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“…5 Dentinal tubule sealing can be secured with the use of restorations, dental adhesives or the formation of a smeared dentin surface. 6 Fluoride varnishes were introduced on the market to increase the efficiency and permanence of fluoride when in contact with the tooth surface, in order to allow a slow and continuous release of fluoride. 7 Varnishes consist of natural resin-based vehicles for fluoride, and are highly adhesive to the tooth structure.…”

Section: Introductionmentioning

confidence: 99%

Desensitizing treatments for dentin hypersensitivity: a randomized, split-mouth clinical trial

et al. 2012

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The aim of this randomized, controlled, split-mouth, clinical study was to differentiate and clinically qualify the effectiveness of different desensitizing agents in the treatment of painful symptoms caused by cervical dentin hypersensitivity (CDH). Two hundred-and-fifty-two teeth of 42 patients were distributed into seven groups (n = 36): G1 -placebo; G2, G3, G4 and G6 -fluoride varnishes; G5 -sodium fluoride; G7 -potassium oxalate. Three applications were made one week apart. A three-score system (Alfa = 0, Bravo = 2, and Charlie = 3, respectively for no sensitivity, slight sensitivity and high sensitivity) was used to assess CDH after each application and after 30 days. The data were subjected to statistical analysis using the Kruskall-Wallis and Dun tests. After the second week, statistically significant differences were observed for all materials compared with the baseline. After 30 days, Group G7 had presented a significant gradual reduction along all the evaluated time intervals. It was concluded that all the desensitizing agents were capable of reducing dentin hypersensitivity, with the exception of the placebo and the sodium fluoride groups.

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“…In the last 10 years, new bioactive materials such as BGs and calcium phosphate‐based ceramics were introduced in Dentistry aiming the treatment of the DH . BGs, in particular, are able to occlude the exposed dentinal tubules reducing the driving of the hydrodynamic stimuli . In fact, BGs can nucleate a hydroxyapatite‐like layer as product of the chemical reaction between their surface and the body fluids, including saliva .…”

Section: Introductionmentioning

confidence: 99%

Bioactive glass plus laser phototherapy as promise candidates for dentine hypersensitivity treatment

et al. 2015

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Treatments for dentine hypersensitivity (DH) may produce positive effects, though do not have lasting results. We investigated the reparative potential of stem cells derived from deciduous teeth (SHEDs) in response to components delivered from substances used in the treatment of the DH, associated or not to laser phototherapy (LPT), to stimulate dentine formation. SHEDs were submitted to substances delivered from a laboratorial P-rich bioactive glass [57SiO -26CaO-17P O (wt %)] or a commercially available desensitizer (Gluma® Desensitizer), associated (or not) to LPT (InGAlP diode laser, 660 nm, 0.028 cm , 20 mW, 5 J/cm , 7 s, contact mode). Biomaterial characterization was performed by X-ray diffraction, scanning electron microscopy and the particle size was evaluated by dynamic light scattering. SHEDs proliferation and differentiation were analyzed by MTT and Alizarin Red staining, respectively. The conditioned media used in these tests were evaluated regarding their pH and the ionic concentration changes due to ions leached from the bioactive glass (BG). BG majority presented a non-crystalline solid structure and mixed particle sizes characterized by the agglomeration of nanoparticles. Cultures treated with BG alone or in association to LPT showed improved cell growth in relation to Gluma (p < 0.05). Gluma was cytotoxic in all tested conditions, regardless irradiated or not. BG associated to LPT induced intense mineral matrix formation. In conclusion, BG releases ionic dissolution products able to promote SHEDs differentiation. BG associated to LPT improves SHEDs proliferation and differentiation in vitro, and may be a promise therapeutic approach for the DH treatment. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 107-116, 2017.

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In Vitro Study of Dentinal Tubule Occlusion with Sol-gel DP-bioglass for Treatment of Dentin Hypersensitivity

Cited by 44 publications

References 23 publications

Phosphorus Effects of Mesoporous Bioactive Glass on Occlude Exposed Dentin

Phosphorus Effects of Mesoporous Bioactive Glass on Occlude Exposed Dentin

Desensitizing treatments for dentin hypersensitivity: a randomized, split-mouth clinical trial

Bioactive glass plus laser phototherapy as promise candidates for dentine hypersensitivity treatment

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