In Vitro Studies of Capreomycin Sulfate Release from Polyethylcyanoacrylate Nanoparticles

Burkeev, M. Zh.; Zhaparova, L.Zh.; Tazhbaev, E. M.; Zhumagalieva, T.S.; Ali, Sayed Ibrahim; Herk, Alex M. van

doi:10.1007/s11094-013-0916-3

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…BSA-INH NPs have shown a sustained release for at least 72 h when compared to the free drug, which we studied earlier in [30], and the results here demonstrated almost 100% release within 5 h. mg/mL. The drug was released from BSA-INH-NPs within 24 h. The initial burst release after 2 h could be due to the desorption of the adsorbed INH from the surface of the particles, which is in agreement with the results observed in [29]. BSA-INH NPs have shown a sustained release for at least 72 h when compared to the free drug, which we studied earlier in [30], and the results here demonstrated almost 100% release within 5 h.…”

Section: Isoniazidsupporting

confidence: 91%

Isoniazid—Loaded Albumin Nanoparticles: Taguchi Optimization Method

et al. 2021

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Tuberculosis is one of the dangerous infectious diseases, killing over a million people worldwide each year. The search for new dosage forms for the treatment of drug-resistant tuberculosis is an actual task. Biocompatible polymer nanoparticles, in particular bovine serum albumin (BSA), are promising drug carriers. Nanoparticle (NP) parameters such as diameter, polydispersity, bioactive substance loading, and NP yield are very important when it comes to drug transport through the bloodstream. The most well-known and widely used first-line anti-tuberculosis drug, isoniazid (INH), is being used as a drug. BSA-INH NPs were obtained by an ethanol desolvation of an aqueous protein solution in the drug presence. The peculiarity of the method is that natural components, namely urea and cysteine, are used for the stabilization of BSA-INH NPs after desolvation. The characteristics of the obtained BSA-INH NPs are significantly affected by the concentration of protein, isoniazid, urea, and cysteine in the solution. The aim of the present study is to investigate the concentration effect of the system reacting components on the parameters of the NPs that are obtained. We have chosen the concentrations of four reacting components, i.e., BSA, isoniazid, urea, and cysteine, as controlling factors and applied the Taguchi method to analyze which concentration of each component has an important effect on BSA-INH NPs characteristics.

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Section: Isoniazidsupporting

confidence: 91%

Isoniazid—Loaded Albumin Nanoparticles: Taguchi Optimization Method

et al. 2021

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“…Further, it was interesting to investigate the polymer degradation process. The polymer biodegradation was determined by dialysis at different pH values at 37°C [38]. Figure 5 shows data on degradation kinetics of PLGA NPs studied by UV-spectrophotometry.…”

Section: T a B L Ementioning

confidence: 99%

Encapsulation of Isoniazid in Polylactide-Co-Glycolide Nanoparticles by Nanoprecipitation

Galiyeva¹,

Tazhbayev²,

Zhumagalieva³

et al. 2022

Bull. of the Kar. Univ. "Chem". Ser.

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The use of polymeric materials as drug carriers has several advantages, such as prolongation of drug action, reduction of drug side effects. In this study, we have considered the methods for the preparation of polylac-tide-co-glycolide (PLGA) polymeric nanoparticles with the anti-tuberculosis drug (ATD) isoniazid by nano-precipitation. Polymeric nanocarriers were obtained by varying individual parameters such as nature of sol-vent and non-solvent, drug/polymer ratio, and stabilizer concentration. It was determined that the average par-ticle size depends on the type of non-solvent. When alcohols were used, the average size increased in the se-quence: ethanol < isopropanol < isobutanol. The type of solvent is an important factor for the formation of nanoparticles and their final characteristics. With an increase in the drug/polymer ratio, the average size of nanoparticles also increased. The size of obtained nanoparticles varied from 93 to 869 nm. Thermogravi-metric and differential scanning calorimetry analyses were carried out to confirm the incorporation of the drug into the polymer matrix. In addition, polymer degradation and the degree of release of isoniazid from the polymeric matrix at different pH were studied. It has been shown that the nanoprecipitation method can be used not only for hydrophobic, but also for hydrophilic drugs.

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Nanoweapons Against Tuberculosis

Jampílek

Kráľová

2020

Nanoformulations in Human Health

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In Vitro Studies of Capreomycin Sulfate Release from Polyethylcyanoacrylate Nanoparticles

Cited by 3 publications

References 8 publications

Isoniazid—Loaded Albumin Nanoparticles: Taguchi Optimization Method

Isoniazid—Loaded Albumin Nanoparticles: Taguchi Optimization Method

Encapsulation of Isoniazid in Polylactide-Co-Glycolide Nanoparticles by Nanoprecipitation

Nanoweapons Against Tuberculosis

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