In vitro response of macrophages to a new carbon-polylactide composite for the treatment of periodontal diseases

Chomyszyn‐Gajewska, Maria; Czajkowska, B.; Błażewicz, M.; Pamuła, Elżbieta; Ptak, Mariusz

doi:10.1016/s0142-9612(01)00128-4

Cited by 10 publications

(8 citation statements)

References 27 publications

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“…It was reported by Chomyszyn‐Gajewska et al40 that in the absence of serum, PLLA did not stimulate the release of IL‐6, IL‐12, and TNF‐α. However, after an initial incubation with serum, the release of IL‐6 and IL‐12 increased dramatically, which was related to the fact that the studied materials have no surface ligands recognizable by macrophages to trigger the synthesis of certain cytokines.…”

Section: Discussionmentioning

confidence: 87%

Mechanical properties of silane‐treated, silica‐particle‐filled polyisoprene rubber composites: Effects of the loading amount and alkoxy group numbers of a silane coupling agent containing mercapto groups

Nakamura

Honda

Harada

et al. 2009

J of Applied Polymer Sci

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ABSTRACT:The surface treatment of spherical silica particles with a silane coupling agent with mercapto groups was carried out. The treated silica particles were incorporated within polyisoprene and then vulcanized. The effects of the loading amount and alkoxy group number of silane on the stress-strain curve of the filled composite were investigated. For this purpose, silanes with dialkoxy and trialkoxy structures were used. The loading amount of silane on the silica surface was varied from 1 to 8 times the amount required for monolayer coverage. The stress at the same strain increased with the silane treatment, and it was higher in the dialkoxy structure than in the trialkoxy structure above 300% strain. There was no significant influence of the loading amount on the stress for the trialkoxy silane structure. However, the stress was influenced by the loading amount, and the maximum stress was observed at 4 times the silane amount required for monolayer coverage for the dialkoxy structure. The stress had a good relationship with the crosslinking density of silica-filled polyisoprene rubber (measured with a swelling test). The reinforcement effect by the silane treatment of silica was found to be affected strongly both by the entanglement of the silane chain and polyisoprene rubber matrix and by the crosslinking reaction between the mercapto group of silane and polyisoprene rubber in the interfacial

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Section: Discussionmentioning

confidence: 87%

Mechanical properties of silane‐treated, silica‐particle‐filled polyisoprene rubber composites: Effects of the loading amount and alkoxy group numbers of a silane coupling agent containing mercapto groups

Nakamura

Honda

Harada

et al. 2009

J of Applied Polymer Sci

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“…The insertion of implants is followed by protein adsorption and subsequent interactions with cellular components of the biological surroundings, in which macrophages play a dominant role through the production of a myriad of signaling molecules. Previous research aimed at using macrophages (either primary cells or cell lines) as a model system to evaluate biomaterial biocompatibility 8–10, 27–33. Additionally, a classification scheme for cytokines was developed, in which their classification is based on their role in inflammation and wound healing 14, 15.…”

Section: Discussionmentioning

confidence: 99%

“…Previous research aimed at using macrophages (either primary cells or cell lines) as a model system to evaluate biomaterial biocompatibility. [8][9][10][27][28][29][30][31][32][33] Additionally, a classification scheme for cytokines was developed, in which their classification is based on their role in inflammation and wound healing. 14,15 In view of this, the present study evaluated (i) gross protein adsorption to, and (ii) in vitro behavior of macrophages on novel biomaterial coatings, consisting of PDL or PAH and DNA, and compared it to negative (noncoated glass) and positive controls (noncoated glass þ LPS-stimulation).…”

Section: Discussionmentioning

confidence: 99%

Macrophage behavior on multilayered DNA‐coatings in vitro

Beucken

Walboomers

Vos

et al. 2007

J Biomedical Materials Res

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A pivotal factor to consider in the development of biomaterials and biomaterial coatings is the inflammatory response to these materials. The insertion of implants is followed by protein adsorption and subsequent interactions with cellular components of the biological surroundings, in which macrophages play a dominant role through the production of a myriad of signaling molecules. In view of this, the aims of the present study were to evaluate (i) gross protein adsorption to, and (ii) in vitro behavior of macrophages on novel biomaterial coatings, composed of poly-D-lysine (PDL) or poly(allylamine hydrochloride) (PAH) and DNA, and to compare these coatings with negative (noncoated glass) and positive controls (noncoated glass + LPS-stimulation). The results demonstrate that multilayered DNA-coatings do not affect gross protein adsorption compared to noncoated controls. Cell culture experiments showed that the attachment to, and viability and morphology of two types of macrophages cultured on multilayered DNA-coatings is comparable to noncoated controls. Still, macrophages repeatedly showed decreased secretion levels of the proinflammatory cytokine TNF-alpha on multilayered DNA-coatings, whereas no differences were observed in the secretion of IL-1beta, IL-10, and TGF-beta1. Appropriate animal studies are required to elucidate if these in vitro indications have clinical effects on the inflammatory and wound healing processes around implants.

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“…In the biological environment, they are involved in a chemical interaction with the organism. Round-edge particles, remaining after the fragmentation process, are assimilated by macrophages which facilitate the process of their phagocytosis [10,11]. Both phagocytosis of carbon particles and its oxidation to gas products results in the partial removal of the implant from the organism.…”

Section: Introductionmentioning

confidence: 99%

Degradation of poly(lactide-co-glycolide) and its composites with carbon fibres and hydroxyapatite in rabbit femoral bone

Morawska-Chochół

Jaworska

Chłopek

et al. 2011

Polymer Degradation and Stability

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In vitro response of macrophages to a new carbon-polylactide composite for the treatment of periodontal diseases

Cited by 10 publications

References 27 publications

Mechanical properties of silane‐treated, silica‐particle‐filled polyisoprene rubber composites: Effects of the loading amount and alkoxy group numbers of a silane coupling agent containing mercapto groups

Mechanical properties of silane‐treated, silica‐particle‐filled polyisoprene rubber composites: Effects of the loading amount and alkoxy group numbers of a silane coupling agent containing mercapto groups

Macrophage behavior on multilayered DNA‐coatings in vitro

Degradation of poly(lactide-co-glycolide) and its composites with carbon fibres and hydroxyapatite in rabbit femoral bone

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