Degradation of poly(lactide-co-glycolide) and its composites with carbon fibres and hydroxyapatite in rabbit femoral bone

Morawska-Chochół, A.; Jaworska, Joanna; Chłopek, J.; Kasperczyk, Janusz; Dobrzyński, P.; Paluszkiewicz, C.; Bajor, Grzegorz

doi:10.1016/j.polymdegradstab.2011.01.005

Cited by 17 publications

(9 citation statements)

References 10 publications

(15 reference statements)

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“…This is in agreement with experimental observations that the vicinity of oxidizing agents accelerates the scission process of polymers [33,34]. However, it should be noted that this phenomenon occurs only at the surface of the PLA components, while hydrolysis is observed inside the bulk, and is connected to water uptake [35]. Fig.…”

Section: Resultssupporting

confidence: 92%

Influence of density and environmental factors on decomposition kinetics of amorphous polylactide – Reactive molecular dynamics studies

Młyniec

Ekiert

Morawska-Chochół

et al. 2016

Journal of Molecular Graphics and Modelling

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Section: Resultssupporting

confidence: 92%

Influence of density and environmental factors on decomposition kinetics of amorphous polylactide – Reactive molecular dynamics studies

Młyniec

Ekiert

Morawska-Chochół

et al. 2016

Journal of Molecular Graphics and Modelling

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“…Two series of experimental tests of poly(lactic-co-glycolic acid) (PLGA) and PLLA blend bioresorbable polymers were performed to quantify the mechanical response of the material. The considered material was originally developed at the Centre of Polymer and Carbon Materials (CPCM) of the Institute of the Polish Academy of Sciences [25,26]. It is a copolymer of lactic acid and glycolic acid (the chemical formula is presented in Figure 1, while the basic physical-chemical properties, based on data provided by CPCM, are presented in Table 1) [27].…”

Section: Experimental Tests Of the Plga Bioresorbable Polymermentioning

confidence: 99%

Experimental Tests, FEM Constitutive Modeling and Validation of PLGA Bioresorbable Polymer for Stent Applications

et al. 2020

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The use of bioresorbable polymers such as poly(lactic-co-glycolic acid) (PLGA) in coronary stents can hypothetically reduce the risk of complications (e.g., restenosis, thrombosis) after percutaneous coronary intervention. However, there is a need for a constitutive modeling strategy that combines the simplicity of implementation with strain rate dependency. Here, a constitutive modeling methodology for PLGA comprising numerical simulation using a finite element method is presented. First, the methodology and results of PLGA experimental tests are presented, with a focus on tension tests of tubular-type specimens with different strain rates. Subsequently, the constitutive modeling methodology is proposed and described. Material model constants are determined based on the results of the experimental tests. Finally, the developed methodology is validated by experimental and numerical comparisons of stent free compression tests with various compression speeds. The validation results show acceptable correlation in terms of both quality and quantity. The proposed and validated constitutive modeling approach for the bioresorbable polymer provides a useful tool for the design and evaluation of bioresorbable stents.

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“…However, incorporating ceramics or other materials into polymers can also modify the rate at which the composite is broken down. Implantation for 24 weeks in New Zealand rabbits showed that poly(lactide-coglycolide) PLGA containing HAP (15 wt.%) is broken down more rapidly than PLGA containing carbon fibers (15 wt.%) or pure PLGA (187).…”

Section: Composite Scaffoldsmentioning

confidence: 99%

Biomimetic materials for controlling bone cell responses

Drevelle¹

2013

Front Biosci

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Bone defects that cannot "heal spontaneously during life" will become an ever greater health problem as populations age. Harvesting autografts has several drawbacks, such as pain and morbidity at both donor and acceptor sites, the limited quantity of material available, and frequently its inappropriate shape. Researchers have therefore developed alternative strategies that involve biomaterials to fill bone defects. These biomaterials must be biocompatible and interact with the surrounding bone tissue to allow their colonization by bone cells and blood vessels. The latest generation biomaterials are not inert; they control cell responses like adhesion, proliferation and differentiation. These biomaterials are called biomimetic materials. This review focuses on the development of third generation materials. We first briefly describe the bone tissue with its cells and matrix, and then how bone cells interact with the extracellular matrix. The next section covers the materials currently used to repair bone defects. Finally, we describe the strategies employed to modify the surface of materials, such as coating with hydroxyapatite and grafting biomolecules.

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Degradation of poly(lactide-co-glycolide) and its composites with carbon fibres and hydroxyapatite in rabbit femoral bone

Cited by 17 publications

References 10 publications

Influence of density and environmental factors on decomposition kinetics of amorphous polylactide – Reactive molecular dynamics studies

Influence of density and environmental factors on decomposition kinetics of amorphous polylactide – Reactive molecular dynamics studies

Experimental Tests, FEM Constitutive Modeling and Validation of PLGA Bioresorbable Polymer for Stent Applications

Biomimetic materials for controlling bone cell responses

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