Biomimetic materials for controlling bone cell responses

Drevelle, Olivier

doi:10.2741/s378

Cited by 13 publications

(12 citation statements)

References 235 publications

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“…Existing literature describing BTE scaffolds bioinspired by bone tissue architecture has shown that their microtopography can control cellular responses through scaffold-cell interactions that activate proliferation and osteogenic differentiation pathways [ 12 ]. The oriented microstructures of scaffolds guide the elongation and growth-orientation of the cells seeded on and into them.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Pore Directionality of Collagen Scaffolds on Cell Differentiation and In Vivo Osteogenesis

et al. 2021

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Although many bone substitutes have been designed and produced, the development of bone tissue engineering products that mimic the microstructural characteristics of native bone remains challenging. It has been shown that pore orientation within collagen scaffolds influences bone matrix formation by the endochondral route. In addition, that the unidirectional orientation of the scaffolds can limit the growth of blood vessels. However, a comparison between the amount of bone that can be formed in scaffolds with different pore orientations in addition to analyzing the effect of loading osteogenic and proangiogenic factors is still required. In this work we fabricated uni- and multidirectional collagen sponges and evaluated their microstructural, physicochemical, mechanical and biological characteristics. Although the porosity and average pore size of the uni- and multidirectional scaffolds was similar (94.5% vs. 97.1% and 260 µm vs. 269 µm, respectively) the unidirectional sponges had a higher tensile strength, Young’s modulus and capacity to uptake liquids than the multidirectional ones (0.271 MPa vs. 0.478 MPa, 9.623 MPa vs. 3.426 MPa and 8000% mass gain vs. 4000%, respectively). Culturing of rat bone marrow mesenchymal stem cells demonstrated that these scaffolds support cell growth and osteoblastic differentiation in the presence of BMP-2 in vitro, although the pore orientation somehow affected cell attachment and differentiation. The evaluation of the ability of the scaffolds to support bone growth when loaded with BMP-2 or BMP-2 + VEGF in an ectopic rat model showed that they both supported bone formation. Histological analysis and quantification of mineralized matrix revealed that the pore orientation of the collagen scaffolds influenced the osteogenic process.

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Section: Introductionmentioning

confidence: 99%

The Effect of Pore Directionality of Collagen Scaffolds on Cell Differentiation and In Vivo Osteogenesis

et al. 2021

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“…As seen, biomaterials are key: besides harbouring viable stem cells and bioactive molecules, a biomaterial used in bone tissue engineering, or one used as a bone substitute, needs to be bioabsorbable, possess sufficient mechanical stability, and mimic the complex porous architecture of bone extracellular matrix (ECM). All these requirements have prompted research on materials bio-reactivity and driven the appearance of the fourth generation of biomaterials: the socalled biomimetic or smart materials (2,3).…”

Section: -Introductionmentioning

confidence: 99%

Surface nitridation improves bone cell response to melt-derived bioactive silicate/borosilicate glass composite scaffolds

et al. 2016

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“…There are many other challenges in the use of peptides-functionalized surfaces, such as the way they are immobilized on the surface to retain their bioactivity, their density and conformation (248). Rezania and Healy compared the effect of peptides derived from BSP (CGGNGEPRGDTYRAY) immobilized on a quartz surface at densities from 0.01 to 3.8 pmol/cm² on the osteoblastic differentiation of rat calvaria osteoblast-like cells (249).…”

Section: Gggggggfhrrikamentioning

confidence: 99%

Interactions between bone cells and biomaterials An update

et al. 2016

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As the populations of the Western world become older, they will suffer more and more from bone defects related to osteoporosis (non-union fractures, vertebral damages), cancers (malignant osteolysis) and infections (osteomyelitis). Autografts are usually used to fill these defects, but they have several drawbacks such as morbidity at the donor site and the amount and quality of bone that can be harvested. Recent scientific milestones made in biomaterials development were shown to be promising to overcome these limitations. Cell interactions with biomaterials can be improved by adding at their surface functional groups such as adhesive peptides and/or growth factors. The development of such biomimetic materials able to control bone cell responses can only proceed if it is based on a sound understanding of bone cell behavior and regulation. This review focuses on bone physiology and the regulation of bone cell differentiation and function, and how the latest advances in biomimetic materials can be translated within promising clinical outcomes.

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Biomimetic materials for controlling bone cell responses

Cited by 13 publications

References 235 publications

The Effect of Pore Directionality of Collagen Scaffolds on Cell Differentiation and In Vivo Osteogenesis

The Effect of Pore Directionality of Collagen Scaffolds on Cell Differentiation and In Vivo Osteogenesis

Surface nitridation improves bone cell response to melt-derived bioactive silicate/borosilicate glass composite scaffolds

Interactions between bone cells and biomaterials An update

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