2008
DOI: 10.1016/j.jdent.2008.07.011
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In vitro remineralization effects of grape seed extract on artificial root caries

Abstract: Grape seed extract (GSE) contains Proanthocyanidin (PA), which has been reported to strengthen collagen-based tissues by increasing collagen cross-links. We used an in vitro pH-cycling model to evaluate the effect of GSE on the remineralization of artificial root caries. Sound human teeth fragments obtained from the cervical portion of the root were stored in a demineralization solution for 96 hr at 37°C to induce artificial root caries lesions. The fragments were then divided into three treatment groups inclu… Show more

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Cited by 175 publications
(173 citation statements)
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References 40 publications
(35 reference statements)
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“…The in vitro secondary caries tests and evaluation methods have been developed that assess demineralized lesions and inhibition zones of dentin due to acid challenge. These methods include polarized light microscopy 7,8,9) , a microhardness test 8,10,11) , microradiography 5,12) , confocal laser-scanning microscopy and the x-ray analytical microscope 13,14) . However, the magnification of such methods is limited if more detailed information at the interface between the cavity and restoration is required.…”
Section: Introductionmentioning
confidence: 99%
“…The in vitro secondary caries tests and evaluation methods have been developed that assess demineralized lesions and inhibition zones of dentin due to acid challenge. These methods include polarized light microscopy 7,8,9) , a microhardness test 8,10,11) , microradiography 5,12) , confocal laser-scanning microscopy and the x-ray analytical microscope 13,14) . However, the magnification of such methods is limited if more detailed information at the interface between the cavity and restoration is required.…”
Section: Introductionmentioning
confidence: 99%
“…22 The results of the present study corroborate and add to the results obtained in a previous study. 6 Based on the results obtained in this in vitro study, GSE inhibits demineralization and promotes remineralization of artificial root carious lesions better than fluoride and CaGP. The probable reasons for lesser activity of fluoride and CaGP compared to GSE include: 1.…”
Section: Jcdpmentioning
confidence: 84%
“…PA from GSE has been demonstrated to increase collagen synthesis and accelerate the conversion of soluble collagen to insoluble collagen during development. 6 PA treated collagen matrices are nontoxic and inhibit enzymatic activity of glucosyltransferase, S.mutans to establish on tooth surface and is of central importance in plaque formation and development of caries. The adherent glucan also contributes to the formation of dental plaque, in which accumulation of acids leads to localized decalcification of enamel surface by facilitating bacterial adherence to tooth surfaces, inter bacterial adhesion and accumulation of biofilms.…”
Section: Discussionmentioning
confidence: 99%
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