Grape Seed Extracts in Dental Therapy

Anusuya, Venkatachalapathy; Jena, Ashok Kumar; Sharan, Jitendra

doi:10.1002/9781119618973.ch15

Cited by 5 publications

(4 citation statements)

References 63 publications

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“…Although, insignificant chlorhexidine showed higher efficacy than the GSE mouthwash. is is attributed to the inhibition of extracellular and interstitial collagenase [7] strengthening of collagen by cross-linking, [2], and reduction of oxidative stress by the PAs present in GSE. Reduction in PI is due to the inhibition of enzyme GTF produced by initial colonizers of plaque.…”

Section: Discussionmentioning

confidence: 99%

“…It is an adherent, polymicrobial colonies within the matrix of exo-polysaccharide, containing an array of diverse species within its ecological alcove. [2] Kumar 2019 states that although mechanical plaque control methods have the potential to maintain adequate levels of oral hygiene, such methods are not being employed accurately. [3] e outand-out removal of dental plaque by mechanical means is difficult even for the most motivated individuals.…”

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confidence: 99%

“…e most abundant polyphenolic compounds present in grape seed are proanthocyanidins (PAs) which account for their anti-inflammatory, antioxidant, anti-proliferative, and cytoprotective properties. ese flavonoids are natural collagen cross-linking [2] and strong oxygen-scavenging agents. [8] ese properties contribute to the potent antiinflammatory and anti-oxidant effect of GSE and make it a potential candidate as an anti-inflammatory agent to reduce the development and progression of gingival inflammation.…”

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confidence: 99%

“…Polyphenols in GSE show a tendency to bind with enzyme glucosyltransferase (GTF), one of the key enzymes produced by the streptococci species, required for the initial cohesion of bacteria to the tooth, making it a potent anti-adhesive agent. [2] In addition, GSE has been proven to have anti-bacterial activity. Among the various polyphenols, procyanidins are the frontman of the antibacterial activity, having a MIC score of 1.0 mg mL −1 against the Streptococcus mutans.…”

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confidence: 99%

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Appraising the Antimicrobial Effect of 2% Grape Seed Extract Mouthwash on Periodontal Pathogens: A Clinicomicrobiological Analysis

Koregol

Kalburgi

Singh

et al. 2023

GJMPBU

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Objectives: The seeds of Vitis vinifera (Grape) are rich in polyphenolic compounds especially proanthocyanidins that show antimicrobial activity as well as have the potential to halt the progression of gingival inflammation by hindering the activity of interstitial collagenase. The aim was to evaluate and compare the effect of Grape seed extract (GSE) and Chlorhexidine mouthwash on Streptoccocus mitis, Streptococcus salivarius, and Aggregatibacter actinomycetemcomitans and correlate with the clinical parameters. Material and Methods: In this randomized, controlled, and double-blinded study, 75 participants were selected from the undergraduate section and divided into three groups, Group A: 25; grape seed extract (2%) mouthwash, Group B: 25; chlorhexidine (0.2%) mouthwash, and Group C: 25; placebo mouthwash. Participants were stipulated to use their assigned mouthwash for 7 days. The supragingival plaque was collected in reduced transport fluid at baseline and 7 days post-intervention and sent for cultural analysis of S. mitis, S. salivarius, and A. actinomycetemcomitans. Colony-forming units (CFUs) were counted and compared for individually selected pathogens at 0 and 7 days among the 3 groups. At each visit, participants were also examined for any clinical changes. Results: Mean scores of all clinical parameters (P = 0.05) and mean CFU of S. mitis, S. salivarius, and A. actinomycetemcomitans (P < 0.001) in Groups A and B (Test Groups) differed significantly as compared to Group C (Control Group) at 7 days post regimen. Intragroup comparison revealed a significant reduction in the mean scores on the 7th day of mouthwash use as compared to baseline in Groups A and B, while Group C showed no significant difference. Conclusion: It was observed that GSE mouthwash has shown a positive effect in reducing selected periodontal pathogens and improvement of clinical parameters when compared to control. It showed comparable efficacy when compared to chlorhexidine. Its biocompatibility, cost effectiveness, easy availability, and no reported topical side effects make it a potential alternative to chlorhexidine. It efficaciously supplements the periodontal therapy.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Appraising the Antimicrobial Effect of 2% Grape Seed Extract Mouthwash on Periodontal Pathogens: A Clinicomicrobiological Analysis

Koregol

Kalburgi

Singh

et al. 2023

GJMPBU

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Natural Dentin Remineralizing Agents

Ameen

2024

Natural Conservative Dentistry: An Alternative Approach to Solve Restorative Problems

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Dentin remineralization is vital for maintaining oral health and preventing tooth decay. Natural dentin remineralizing agents have gained significant attention as a promising alternative to synthetic remineralizing agents due to their biocompatibility, low cost, and minimal adverse effects. This book chapter provides a comprehensive overview of various natural dentin remineralizing agents and their potential applications in dental therapy. The mechanisms underlying the remineralization process, the properties and sources of natural dentin remineralizing agents, and the techniques used for their extraction and formulation are discussed. Additionally, the in vitro and in vivo studies investigating the effectiveness of natural dentin remineralizing agents in restoring tooth mineralization and preventing dental caries are highlighted. Finally, the future prospects and challenges are discussed. This book chapter provides a valuable resource for dental professionals, researchers, and students interested in natural dentin remineralization and its potential applications in dentistry.

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Natural Dental Antioxidants

Essam

2024

Natural Conservative Dentistry: An Alternative Approach to Solve Restorative Problems

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Discoloration of teeth is a common concern among patients seeking cosmetic treatment. The color of teeth can be affected by various factors, both internal and external, such as ingestion of chemicals or consumption of foods that can cause staining. Currently, there are numerous products available in the market that claim to remove stains and whiten teeth. These options include professional prophylaxis, bleaching gels applied to vital teeth for home use, or supervised application in a dental office. Bleaching gels typically contain varying concentrations of carbamide or hydrogen peroxide and are applied using different methods, resulting in different activation mechanisms that promote tooth bleaching through oxi-reduction reactions. Unfortunately, bleaching agents have an adverse effect on bonding to enamel. This is because of the free radicals generated by the breakdown of hydrogen peroxidecontaining bleaching agents. The free radicals hinder the resin infiltration in the interprismatic spaces, inhibit resin polymerization , and restrict resin tag creation. These free radicals are eliminated from the body within a span of 24 hours to 3 weeks, and the bond strength to enamel is restored. So bonding should be postponed for 1-3 weeks so that the bond strength is restored, but this waiting period is not always clinically possible. The use of antioxidants could be a possible solution to immediately restore the reduced bond strength. Antioxidants could be either synthetic or natural. Although synthetic antioxidants proved to have the ability to restore bond strength, they have many adverse effects. Natural antioxidants could be a good alternative to synthetic ones with no side effects.

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Grape Seed Extracts in Dental Therapy

Cited by 5 publications

References 63 publications

Appraising the Antimicrobial Effect of 2% Grape Seed Extract Mouthwash on Periodontal Pathogens: A Clinicomicrobiological Analysis

Appraising the Antimicrobial Effect of 2% Grape Seed Extract Mouthwash on Periodontal Pathogens: A Clinicomicrobiological Analysis

Natural Dentin Remineralizing Agents

Natural Dental Antioxidants

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