In vitro release of soluble CD23 by human lymphocytes in ragweed-sensitive versus nonatopic patients following stimulation with ragweed antigen E

Distinct modulation by interferon-gamma (IFN-γ) of CD23 expression on B and T lymphocytes of atopic subjects

“…In our study, atopic patients showed lower sCD23 levels than healthy individuals, in agreement with Batterman et al [23]. This is in contrast with former reports [24][25][26], but the differences in methods used and the overlap between the ranges of sCD23 concentrations in atopic and non-atopic individuals may explain the discrepancies.…”

TLR4-Mediated Signaling Induces MMP9-Dependent Cleavage of B Cell Surface CD23

“…Der p1, a major allergen of house dust mite Dermatophagoides pteronyssinus , has been shown to induce cleavage of mCD23 from human B lymphocytes resulting in accumulation of sCD23 in culture supernatants (10, 11). Patients with atopic dermatitis (12, 13) or allergies to grass pollen (6), birch pollen (14), parietaria pollen (15), ragweed pollen (16), or cow’s milk (17) exhibit increased sCD23 in peripheral blood suggesting that there must be alternative mechanisms for induction of sCD23 generation. Interestingly, it has been shown that the severity of asthma induced by exposure to the house dust mite is not solely a function of the concentration of the mite in dust, rather the amount of endotoxin in the dust (18).…”