In vitro release kinetics of drugs from silica aerogels loaded by different modes and conditions using supercritical CO2

Singh, Neha; Vinjamur, Madhu; Mukhopadhyay, Mausumi

doi:10.1016/j.supflu.2020.105142

Cited by 5 publications

(5 citation statements)

References 20 publications

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“…However, the nucleation rates for these conditions are also high. More details about these nucleation and growth rates during depressurization are shown in our previous work …”

Section: Resultsmentioning

confidence: 99%

“…More details about these nucleation and growth rates during depressurization are shown in our previous work. 32 Supersaturation, Nucleation, and Growth of Ibuprofen and Benzoic Acid. The modeling results of depressurization of the scCO 2 phase with dissolved ibuprofen and benzoic acid also exhibit similar results (not shown here) to those of fenofibrate.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Insights into Adsorptive Drug Loading on Silica Aerogels from Supercritical CO₂

2022

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This work gives an insight into the process of adsorptive drug loading in silica aerogels from supercritical CO2 (scCO2). A prevalent method for such loading entails bringing the aerogels into contact with the drug–scCO2 solution followed by slow or isothermal depressurization. Our previous work established that drug precipitates during depressurization. Consequently, the adsorptive drug loading measured by the prevalent method includes precipitation. An alternative method is presented for accurate measurement of adsorption avoiding precipitation. To illustrate the disparity between the two methods, the concentration dependence of drug loadings in scCO2, obtained by both methods, is compared for fenofibrate, ibuprofen, and benzoic acid. A mechanism is proposed, and a mathematical model is developed for comparing the adsorptive drug loadings by both methods. The loading obtained by the present method is found to be much less than that by the prevalent method, though both correlate well with the formalism of the Langmuir adsorption equation with the same equilibrium constant at low concentrations. Equations are developed for the concentration dependence of drug loadings measured by both methods at all concentrations in scCO2.

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“…However, the nucleation rates for these conditions are also high. More details about these nucleation and growth rates during depressurization are shown in our previous work …”

Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Insights into Adsorptive Drug Loading on Silica Aerogels from Supercritical CO₂

2022

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“…The release kinetic curve of SAA@SiO 2 and SOA@SiO 2 was measured by the following method. The agent-loaded aerogels were added to the dissolving medium, which was a 0.1 M HCl solution containing 1% sodium lauryl sulfate. , The agents were uniformly distributed in the container at a constant temperature of 37 (±0.5) °C and a stirring speed of 100 rpm. At predetermined time intervals, 2 mL of the sample solution was taken from the container each time, and 2 mL of fresh culture medium solution was added at the same time.…”

Section: Experimental Sectionmentioning

confidence: 99%

“…Within the absolute average relative deviation (AARD) of 3.5% concentration, the absorbance/concentration standard curve of each agent was further drawn to determine the unknown concentration of the sample at any time during the release process. The net released at any time was calculated by the formula of the previous researcher . The release kinetic curve of pure salicylic acid and sorbic acid was tested in the same way.…”

Section: Experimental Sectionmentioning

confidence: 99%

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Efficient Antibacterial Agent Delivery by Mesoporous Silica Aerogel

Xie

Liu

et al. 2022

ACS Omega

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Bacterial infections still cause many health problems for human beings. Silica aerogels with a three-dimensional (3D) porous structure and a large surficial area are promising candidates for drug delivery, but they have rarely been investigated for antibacterial agent delivery. Herein, we study mesoporous silica aerogels as carriers for delivery of three slightly soluble antibacterial agents including cinnamaldehyde (CA, liquid), salicylic acid (SAA, solid), and sorbic acid (SOA, solid) under supercritical fluid carbon dioxide. Notably, all three antibacterial agents form uniform nanocrystals in the mesopores of silica aerogels and the loading efficiency reaches 56 wt %, which assists in overcoming the obstacles of low bioavailability of slightly soluble antibacterial agents. Benefiting from nanocrystallized antibacterial agents, the agent-loaded aerogels exhibit an inhibition rate of 99.99% against Escherichia coli during the initial release; notably, they still have a 95% inhibition rate even after ∼90% of CA is released. Importantly, the agent-loaded silica aerogels demonstrate good biocompatibility in vitro. This work indicates that mesoporous silica aerogels are a promising platform for antibacterial agent delivery.

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Novel organic-inorganic composite pea protein silica food-grade aerogel materials: Fabrication, mechanisms, high oil-holding property and curcumin delivery capacity

Yang,

Li,

Guo

et al. 2024

International Journal of Biological Macromolecules

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In vitro release kinetics of drugs from silica aerogels loaded by different modes and conditions using supercritical CO2

Cited by 5 publications

References 20 publications

Insights into Adsorptive Drug Loading on Silica Aerogels from Supercritical CO₂

Insights into Adsorptive Drug Loading on Silica Aerogels from Supercritical CO₂

Efficient Antibacterial Agent Delivery by Mesoporous Silica Aerogel

Novel organic-inorganic composite pea protein silica food-grade aerogel materials: Fabrication, mechanisms, high oil-holding property and curcumin delivery capacity

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In vitro release kinetics of drugs from silica aerogels loaded by different modes and conditions using supercritical CO2

Cited by 5 publications

References 20 publications

Insights into Adsorptive Drug Loading on Silica Aerogels from Supercritical CO2

Insights into Adsorptive Drug Loading on Silica Aerogels from Supercritical CO2

Efficient Antibacterial Agent Delivery by Mesoporous Silica Aerogel

Novel organic-inorganic composite pea protein silica food-grade aerogel materials: Fabrication, mechanisms, high oil-holding property and curcumin delivery capacity

Contact Info

Product

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About

Insights into Adsorptive Drug Loading on Silica Aerogels from Supercritical CO₂

Insights into Adsorptive Drug Loading on Silica Aerogels from Supercritical CO₂