Efficient Antibacterial Agent Delivery by Mesoporous Silica Aerogel

Xie, Hui; He, Zhiguo; Liu, Yanxing; Zhao, Changbo; Guo, Bing; Zhu, Caizhen; Xu, Jie

doi:10.1021/acsomega.1c06198

Cited by 17 publications

(8 citation statements)

References 44 publications

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“…Along with the antibacterial effect, the aggregated hydroxyapatite could prevent secondary caries besides closing the microleakage. Silica nanoparticle is known for its biocompatible and when antibacterial agent is combined with the porous silica long-lasting antibacterial effect was demonstrated [ 43 , 44 ]. In addition, the aggregated emission is known for its multifunctional properties including therapeutic effects [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Novel antibacterial and apatite forming restorative composite resin incorporated with hydrated calcium silicate

et al. 2023

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Background White Portland cement is a calcium silicate material. It exhibits antibacterial properties and is biocompatible. In addition, calcium silicate-based materials are known to release calcium ions and form apatite. The purpose of this study was to develop a novel bioactive restorative resin composite with antibacterial and apatite forming properties to prevent tooth caries at the interface of teeth and restorative materials, by incorporation of hydrated calcium silicate (hCS) derived from white Portland cement. Methods To prepare the experimental composite resins, a 30 wt% light-curable resin matrix and 70 wt% filler, which was mixed with hCS and silanized glass powder were prepared in following concentrations: 0, 17.5, 35.0, and 52.5 wt% hCS filler. The depth of cure, flexural strength, water sorption, solubility, and antibacterial effect were tested. After immersion in artificial saliva solution for 15, 30, 60, and 90 days, ion concentration by ICP-MS and apatite formation using SEM-EDS, Raman spectroscopy and XRD from experimental specimens were analyzed. Results All experimental groups showed clinically acceptable depths of cure and flexural strength for the use as the restorative composite resin. Water sorption, solubility, released Ca and Si ions increased with the addition of hCS to the experimental composite resin. Experimental groups containing hCS showed greater antibacterial effects compared with the 0 wt% hCS filler group (p < 0.05). The 52.5 wt% hCS filler group produced precipitates mainly composed of Ca and P detected as hydroxyapatite after immersion in artificial saliva solution for 30, 60, and 90 days. Conclusions This results show that composite resins containing hCS filler is effective in antibacterial effects. hCS has also apatite formation ability for reducing gap size of microleakage by accumulating hydroxyapatite precipitates at the restoration-tooth interface. Therefore, novel composite resin containing hCS is promising bioactive resin because of its clinically acceptable physiochemical properties, antibacterial properties, and self-sealing potential for prevention of microleakage for longer usage of restorations.

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Section: Discussionmentioning

confidence: 99%

Novel antibacterial and apatite forming restorative composite resin incorporated with hydrated calcium silicate

et al. 2023

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“…Xie et al examined 3D porous silica aerogel as carriers for antibacterial compound release, specifically cinnamaldehyde, salicylic acid, and sorbic acid. They discovered that the aerogel inhibited Escherichia coli ( E. coli ) during the initial stage; interestingly, they were still efficient when 90% of the cinnamaldehyde was dissipated [ 96 ]. They came to the conclusion that mesoporous silica aerogel is an interesting antibacterial vehicle.…”

Section: Biomedical Applications Of Aerogelmentioning

confidence: 99%

Emerging Trends in Nanotechnology: Aerogel-Based Materials for Biomedical Applications

et al. 2023

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At present, aerogel is one of the most interesting materials globally. The network of aerogel consists of pores with nanometer widths, which leads to a variety of functional properties and broad applications. Aerogel is categorized as inorganic, organic, carbon, and biopolymers, and can be modified by the addition of advanced materials and nanofillers. Herein, this review critically discusses the basic preparation of aerogel from the sol–gel reaction with derivation and modification of a standard method to produce various aerogels for diverse functionalities. In addition, the biocompatibility of various types of aerogels were elaborated. Then, biomedical applications of aerogel were focused on this review as a drug delivery carrier, wound healing agent, antioxidant, anti-toxicity, bone regenerative, cartilage tissue activities and in dental fields. The clinical status of aerogel in the biomedical sector is shown to be similarly far from adequate. Moreover, due to their remarkable properties, aerogels are found to be preferably used as tissue scaffolds and drug delivery systems. The advanced studies in areas including self-healing, additive manufacturing (AM) technology, toxicity, and fluorescent-based aerogel are crucially important and are further addressed.

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“…It has a particle size that is smaller than the wavelength of visible light [12]. Moreover, to be classified as aerogel, it has to be of ultra-low density (porosity of >99%), making it a favorable material in thermal insulation [13], catalyst [14], chemical adsorption and absorption [15], chemical sensors [16], dielectric material [17], and medical applications (i.e., Drug delivery) [18].…”

Section: Introductionmentioning

confidence: 99%

Effect of Silicone Modifier on the Physical Properties of Flexible Silica Aerogels

et al. 2023

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Research on the development of flexible silica aerogels (FSAs) has been ongoing due to their excellent thermal insulation, low density, and high elasticity. However, the physical properties of FSAs, such as density, thermal conductivity, mechanical strength, and surface wettability, are highly dependent on the preparation conditions. To achieve the desired properties of FSAs for various applications, it is necessary to develop a method to fine-tune their physical properties. In this paper, two modifiers of methyltrimethoxysilane (MTMS)/trimethylethoxysilane (TMES) were employed to fine-tune the bulk density of a series of flexible silica aerogels (FSAs), reflecting a series of FSAs with fine-tunable physical properties. First, the precursor was synthesized by a click reaction between vinyltrimethoxysilane (VTMS) and 2,2′ (ethylenedioxy) diethanethiol (EDDET). The VTMS, EDDET, and the as-prepared precursor were characterized by FT-IR and NMR spectroscopy. Subsequently, the precursor was converted into a series of FSAs (denoted by FSA, FSA-M, and FSA-T) through conventional sol-gel reactions with/without MTMS/TMES. Chemical structures of synthesized FSAs were confirmed by 13C and 29Si solid-state NMR spectroscopy. The porous structure of FSAs was identified by BET and SEM, respectively. Physical properties, such as thermal conductivity, mechanical strength, and surface wettability of FSAs were determined by a Hot Disk, durometer/DMA in compression mode, and contact angle measurements, respectively. This study found FSAs containing none, 1 wt%, 5 wt%, and 10 wt% of MTMS increase the density of FSAs from 0.419 g/cm3 (FSA), 0.423 g/cm3 (FSA-M1), 0.448 g/cm3 (FSA-M5), and 0.456 g/cm3 (FSA-M10). It should be noted that the thermal conductivity, surface hardness, bulk mechanical strength, and hydrophobicity of FSA-Ms of increasing MTMS loading were all found to show a rising trend, while FSA-Ts exhibited lower density. FSA-T10 exhibited lower thermal conductivity, surface hardness, and bulk mechanical strength as compared to FSA. However, it was found to show higher hydrophobicity as compared to that of FSA.

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Efficient Antibacterial Agent Delivery by Mesoporous Silica Aerogel

Cited by 17 publications

References 44 publications

Novel antibacterial and apatite forming restorative composite resin incorporated with hydrated calcium silicate

Novel antibacterial and apatite forming restorative composite resin incorporated with hydrated calcium silicate

Emerging Trends in Nanotechnology: Aerogel-Based Materials for Biomedical Applications

Effect of Silicone Modifier on the Physical Properties of Flexible Silica Aerogels

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