In vitro oxidized HDL and HDL from type 2 diabetes patients have reduced ability to efflux oxysterols from THP-1 macrophages

Chen, Yinan; Arnal-Levron, Maud; Hullin-Matsuda, Françoise; Knibbe, Carole; Moulin, Philippe; Luquain-Costaz, Céline; Delton, Isabelle

doi:10.1016/j.biochi.2018.04.018

Cited by 12 publications

(7 citation statements)

References 32 publications

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“…High triglycerides and low HDL cholesterol are well-established cardiovascular risk factors for progressive atherosclerosis. One described beneficial effect of vitamin C is by inhibiting lipid peroxidation in HDL, thus preserving its antioxidant activity [ 25 ], as oxidation of HDL impairs cholesterol efflux capacity and its cardioprotective effect [ 26 , 27 ]. Although differences in HDL-cholesterol between KTR according to increasing tertiles of vitamin C, with respective mean values of 1.0, 1.1, and 1.2 mmol/L, may seem numerically marginal at first sight, it should be noted that small differences in HDL cholesterol may already be associated with relatively large differences in incidence of atherosclerosis-related disease.…”

Section: Discussionmentioning

confidence: 99%

“…It works as an enhancer to catalyze the conversion of acidified nitrite to NO, resulting in an increased NO pool [ 62 , 66 , 67 ], thus linking vitamin C-targeted interventions with augmentation of NO, reduction in oxidative stress, and anti-atherosclerotic effects. By scavenging reactive oxygen species, vitamin C also facilitates inhibition of lipid peroxidation of HDL, preserving, in turn, antioxidant activity of HDL [ 29 ], which is relevant for its cholesterol efflux ability and protective effect on the vasculature [ 27 , 28 ], contributing to prevent or reverse intragraft atherosclerosis, and thereby slowing the decline in kidney function. These findings are in agreement with the aforementioned previous report of our group [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin C is a recognized antioxidant and anti-inflammatory compound that attenuates oxidative stress [ 24 ], with solid pathophysiological rationale for its use in patients on renal replacement therapy and a good safety profile [ 25 , 26 ]. It inhibits lipid peroxidation in high-density lipoprotein (HDL) cholesterol [ 27 , 28 , 29 ]. Our group recently reported that HDL efflux capacity is associated with increased risk of graft failure in KTR, likely through an impact on progressive intra-graft vasculature atherosclerosis [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

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Plasma Vitamin C and Risk of Late Graft Failure in Kidney Transplant Recipients: Results of the TransplantLines Biobank and Cohort Study

et al. 2021

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Recent studies have shown that depletion of vitamin C is frequent in outpatient kidney transplant recipients (KTR) and that vitamin C is inversely associated with risk of death. Whether plasma vitamin C is associated with death-censored kidney graft failure remains unknown. We investigated KTR who participated in the TransplantLines Insulin Resistance and Inflammation Biobank and Cohort Study. The primary outcome was graft failure (restart of dialysis or re-transplantation). Overall and stratified (pinteraction < 0.1) multivariable-adjusted Cox regression analyses are presented here. Among 598 KTR (age 51 ± 12 years-old; 55% males), baseline median (IQR) plasma vitamin C was 44.0 (31.0–55.3) µmol/L. Through a median follow-up of 9.5 (IQR, 6.3‒10.2) years, 75 KTR developed graft failure (34, 26, and 15 events over increasing tertiles of vitamin C, log-rank p < 0.001). Plasma vitamin C was inversely associated with risk of graft failure (HR per 1–SD increment, 0.69; 95% CI 0.54–0.89; p = 0.004), particularly among KTR with triglycerides ≥1.9 mmol/L (HR 0.46; 95% CI 0.30–0.70; p < 0.001; pinteraction = 0.01) and among KTR with HDL cholesterol ≥0.91 mmol/L (HR 0.56; 95% CI 0.38–0.84; p = 0.01; pinteraction = 0.04). These findings remained materially unchanged in multivariable-adjusted analyses (donor, recipient, and transplant characteristics, including estimated glomerular filtration rate and proteinuria), were consistent in categorical analyses according to tertiles of plasma vitamin C, and robust after exclusion of outliers. Plasma vitamin C in outpatient KTR is inversely associated with risk of late graft failure. Whether plasma vitamin C‒targeted therapeutic strategies represent novel opportunities to ease important burden of graft failure necessitates further studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Plasma Vitamin C and Risk of Late Graft Failure in Kidney Transplant Recipients: Results of the TransplantLines Biobank and Cohort Study

et al. 2021

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“…The altered composition of HDL is related to alterations in its functionality, mainly that associated with cholesterol efflux 50 . A study of patients with T2DM documented that modifications in HDL particles, such as oxidation and glycation, which alter the composition of HDL, decrease the cholesterol efflux of HDL 51 . It would be important to carry out future studies to assess whether there is an association between altered distribution and composition of HDL subpopulations and cholesterol efflux in T2DM youth.…”

Section: Discussionmentioning

confidence: 99%

Effects of fatty liver on the size and composition of high‐density lipoprotein cholesterol subpopulations in adolescents with type 2 diabetes mellitus

et al. 2020

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Background: Type 2 diabetes mellitus (T2DM) is an emerging disease in the pediatric population. The association between T2DM and non-alcoholic fatty liver disease (NAFLD) has been described. Recent evidence suggests that sizes and composition of high-density lipoprotein (HDL) may be more important that HDL-C levels in predicting coronary heart disease. There is not data regarding the HDL subclasses distribution and composition in T2DM youths with NAFLD. Methods: This cross-sectional study included 47 adolescents with T2DM and 23 nondiabetic controls of both sexes aged 10 to 18 years. The presence of NAFLD was determined estimated proton density fat fraction (PDFF) by magnetic resonance by spectroscopy. We compared the HDL subclasses distribution (HDL2b, HDL2a, HDL3a HDL3b and HDL3c) and the HDL chemical composition (total protein, triglyceride, phospholipid, cholesteryl esters, and free cholesterol) between the groups of adolescents with T2DM and the control group. Results: Patients with T2DM and NAFLD had a significantly lower proportion HDL2b (P = .040) and a higher proportion of HDL3c (P = .035); higher proportion of TG

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“…Oxidation of HDL alters the functions of HDL. Modified HDL, either by copper-induced oxidation or treatment with acrolein, reduced cholesterol transport activity of HDL [65,66]. Oxidation of Met112 or chlorination of Tyr192 of apoA1 by MPO-dependent modifications reduced its cholesterol efflux capacity [60,63].…”

Section: The Presence Of Oxhdl and Its Possible Functionmentioning

confidence: 99%

Structure and Dynamics of Oxidized Lipoproteins In Vivo: Roles of High-Density Lipoprotein

et al. 2021

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Oxidative modification of lipoproteins is implicated in the occurrence and development of atherosclerotic lesions. Earlier studies have elucidated on the mechanisms of foam cell formation and lipid accumulation in these lesions, which is mediated by scavenger receptor-mediated endocytosis of oxidized low-density lipoprotein (oxLDL). Mounting clinical evidence has supported the involvement of oxLDL in cardiovascular diseases. High-density lipoprotein (HDL) is known as anti-atherogenic; however, recent studies have shown circulating oxidized HDL (oxHDL) is related to cardiovascular diseases. A modified structure of oxLDL, which was increased in the plasma of patients with acute myocardial infarction, was characterized. It had two unique features: (1) a fraction of oxLDL accompanied oxHDL, and (2) apoA1 was heavily modified, while modification of apoB, and the accumulation of oxidized phosphatidylcholine (oxPC) and lysophosphatidylcholine (lysoPC) was less pronounced. When LDL and HDL were present at the same time, oxidized lipoproteins actively interacted with each other, and oxPC and lysoPC were transferred to another lipoprotein particle and enzymatically metabolized rapidly. This brief review provides a novel view on the dynamics of oxLDL and oxHDL in circulation.

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In vitro oxidized HDL and HDL from type 2 diabetes patients have reduced ability to efflux oxysterols from THP-1 macrophages

Cited by 12 publications

References 32 publications

Plasma Vitamin C and Risk of Late Graft Failure in Kidney Transplant Recipients: Results of the TransplantLines Biobank and Cohort Study

Plasma Vitamin C and Risk of Late Graft Failure in Kidney Transplant Recipients: Results of the TransplantLines Biobank and Cohort Study

Effects of fatty liver on the size and composition of high‐density lipoprotein cholesterol subpopulations in adolescents with type 2 diabetes mellitus

Structure and Dynamics of Oxidized Lipoproteins In Vivo: Roles of High-Density Lipoprotein

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