In Vitro NMR Evaluation of Human Thyroid Lesions

A potential diagnostic application of magnetization transfer contrast: anin vitroNMR study of excised human thyroid tissues

“…The data reported here are confined to those which we believe to represent as yet unreported and clinically significant findings. Our T 1 data are consistent with those reported by Johnson et al (1989).…”

“…Using standard in vitro T 1 and T 2 measurements, several authors have described in vitro N.M.R. studies of thyroid tissue (Tennvall et al 1984, Johnson et al 1989, Tregnaghi et al 1991. Tennvall et al (1984) found small differences in T 1 and T 2 between colloid, fibrous and malignant thyroid tissues.…”

“…Tennvall et al (1984) found small differences in T 1 and T 2 between colloid, fibrous and malignant thyroid tissues. Johnson et al (1989) recorded T 1 values at 0.5 tesla for uninvolved and pathological material, including goitre, benign and malignant disease, and found a statistically significant difference between normal and malignant disease. There was, however, some overlap between T 1 values obtained from benign and malignant thyroid lesions.…”

Quantitation by1H-NMR of dolichol, cholesterol and choline-containing lipids in extracts of normal and phathological thyroid tissue

“…Although other types of thyroid cancers remain to be examined, it appears that 1 H-NMR spectroscopy can provide important information for the diagnosis of thyroid nodules. [29][30][31] The high levels of dolichol found in normal thyroid indicate that dolichol may be a major constituent of membranes in normal thyroid and could affect membrane structure, fluidity and enzyme functions. 32 Desruisseau et al 33 reported that the synthesis of dolichol was activated by TSH (thyroid stimulating hormone) in a culture system of porcine cells.…”