IN VITRO NITRIC OXIDE SCAVENGING AND ANTI INFLAMMATORY ACTIVITIES OF DIFFERENT SOLVENT EXTRACTS OF VARIOUS PARTS OF Musa paradisiaca

Rao, U.S. Mahadeva

doi:10.17576/mjas-2016-2005-26

Cited by 25 publications

(16 citation statements)

References 28 publications

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“…Previous studies discovered the presence of both constitutive nitric oxide synthase (c-NOS) and iNOS in rat and human lungs (Syed et al 2016). In spite of the fact that nitric oxide (NO) is involved in anti-inflammatory, antimicrobial and antioxidant actions, excess NO production may be deleterious (Rao et al 2016). NO is similar to H 2 S as it may act as a pro-inflammatory or anti-inflammatory agent according to its concentration.…”

Section: Immunohistochemical Assessment Of Inosmentioning

confidence: 99%

H2S attenuates acute lung inflammation induced by administration of lipopolysaccharide in adult male rats

Ali¹,

Abdel-Hamid²,

Toni³

2018

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. Hydrogen sulfide (H2S) is gasotransmitter which plays an important role in human physiology. In this study, we aimed to check the effect of H2S treatment on acute lung inflammation (ALI). Thirty-six adult male albino rats were used and divided into: control group, ALI group which was intraperitoneally (i.p.) injected with lipopolysaccharide (LPS) at a dose of 5 mg/kg body weight, ALI group treated by the H2S donor; sodium hydrosulfide (NaHS) at a dose of 10 mg/kg body weight i.p. and ALI group treated by i.p. injection of 80 mg/kg body weight DL- propargylglycine (PAG) which is an inhibitor of endogenous H2S synthesis. Serum was obtained to determine interleukin-6 (IL-6) levels. Lipid peroxides and total antioxidant capacity (TAC) levels were measured in lung. Lung histopathology and expression of inducible nitric oxide synthase (iNOS) were also done. Results showed that NaHS improved lung inflammation through its inhibitory effect on iNOS expression, decreasing the levels of IL-6 and lipid peroxides and increasing TAC levels. But, ALI was exacerbated with PAG administration. In conclusion, the results proved that H2S has a protective effect against LPS induced ALI due to its anti-nitrative, anti-oxidant and anti-inflammatory properties.

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Section: Immunohistochemical Assessment Of Inosmentioning

confidence: 99%

H2S attenuates acute lung inflammation induced by administration of lipopolysaccharide in adult male rats

Ali¹,

Abdel-Hamid²,

Toni³

2018

gpb

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“…Nitric Oxide is produced in mammalian cells, and is responsible for various physiological processes, including fighting viruses and bacteria. However, excessive production of NO is associated with a number of ailments such as airway inflammation in asthma patients (Rao et al, 2016). The NO radical is known to react with superoxide radical anion (O 2 -) to form peroxynitrite (ONOO -), which is a cytotoxic molecule (Rintu et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

In vitro anti-inflammatory activity of Vangueria infausta: An edible wild fruit from Zimbabwe

Gwatidzo¹,

Chowe²,

Cexton³

2018

Afr. J. Pharm. Pharmacol.

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This study set out to investigate the anti-inflammatory activity of Vangueria infausta, an edible wild fruit from Zimbabwe. The importance lies in the fact that this plant species could be developed as a low cost and effective therapeutic agent, with little or no side effects from natural sources. The fruit pulp of V. infausta was subjected to cold ethanol extraction to get crude extract. Flavonoids were isolated by thin layer chromatography (TLC) and unsaponifiable matter by liquid-liquid extraction using petroleum ether. The three were assayed by egg albumin denaturation and Nitric Oxide radical scavenging assays. Unsaponifiable fraction, crude ethanol extract and flavonoid fraction exhibited potent anti-inflammatory activity with a high of 93.12±0.03% (at 400 mg/L), 79.91±0.042% (at 800 mg/L) and 54.40±0.061% (at 800 mg/L), respectively in the egg albumin denaturation assay, whereas, in the nitric oxide (NO) radical scavenging assay it was respectively 68.99±0.058% (800 mg/L), 82.85±0.047% (at 800 mg/L) and 33.46±0.036% (at 800 mg/L). V. infausta crude extract and unsaponifiable fraction were superior to indomethacin and quercetin standards at lower concentrations in the egg albumin inhibition assay. This study shows that V. infausta possess potent anti-inflammatory phytochemicals that could be developed into anti-inflammatory drugs.

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“…Nitric Oxide Scavenging Assay (NO) Nitric oxide (NO) is an indicator of inflammation. It is an important chemical mediator produced by endothelial cells, macrophages and neurons, and is involved in the regulation of many different physiological processes [84]. An excess amount of nitric oxide (NO) is associated with several diseases, i.e., inflammation, cancer and other pathological conditions.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

One-Pot Multicomponent Synthesis and Bioevaluation of Tetrahydroquinoline Derivatives as Potential Antioxidants, α-Amylase Enzyme Inhibitors, Anti-Cancerous and Anti-Inflammatory Agents

et al. 2020

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Mankind has always suffered from multiple diseases. Therefore, there has been a rigorous need in the field of medicinal chemistry for the design and discovery of new and potent molecular entities. In this work, thirteen tetrahydroquinoline derivatives were synthesized and evaluated biologically for their antioxidant, α-amylase enzyme inhibitory, anti-proliferative and anti-inflammatory activities. SF8 showed the lowest IC50 of 29.19 ± 0.25 µg/mL by scavenging DPPH free radicals. SF5 showed significant antioxidant activity in total antioxidant capacity (TAC) and total reducing power (TRP) assays. SF5 and SF9 showed the maximum inhibition of α-amylase enzyme i.e., 97.47% and 89.93%, respectively, at 200 µg/mL concentration. Five compounds were shortlisted to determine their anti-proliferative potential against Hep-2C cells. The study was conducted for 24, 48 and 72 h. SF8 showed significant results, having an IC50 value of 11.9 ± 1.04 µM at 72 h when compared with standard cisplatin (IC50 value of 14.6 ± 1.01 µM). An in vitro nitric oxide (NO) assay was performed to select compounds for in vivo anti-inflammatory activity evaluation. SF13 scavenged the NO level to a maximum of 85% at 50 µM concentration, followed by SF1 and SF2. Based on the NO scavenging assay results, in vivo anti-inflammatory studies were also performed and the results showed significant activity compared to the standard, acetylsalicylic acid (ASA).

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IN VITRO NITRIC OXIDE SCAVENGING AND ANTI INFLAMMATORY ACTIVITIES OF DIFFERENT SOLVENT EXTRACTS OF VARIOUS PARTS OF Musa paradisiaca

Cited by 25 publications

References 28 publications

H2S attenuates acute lung inflammation induced by administration of lipopolysaccharide in adult male rats

H2S attenuates acute lung inflammation induced by administration of lipopolysaccharide in adult male rats

In vitro anti-inflammatory activity of Vangueria infausta: An edible wild fruit from Zimbabwe

One-Pot Multicomponent Synthesis and Bioevaluation of Tetrahydroquinoline Derivatives as Potential Antioxidants, α-Amylase Enzyme Inhibitors, Anti-Cancerous and Anti-Inflammatory Agents

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