In-vitro nanodiagnostic platform through nanoparticles and DNA-RNA nanotechnology

Chan, Ki; Ng, Tzi Bun

doi:10.1007/s00253-015-6506-4

Cited by 9 publications

(6 citation statements)

References 29 publications

(47 reference statements)

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“…For more detailed information on RNA based in vitro diagnostics, readers are encouraged to refer to articles referenced in this review. 215 − 217 …”

Section: Applications In Nanomedicine and Nanobiotechnologymentioning

confidence: 99%

“…RNA nanotechnology could facilitate further development of aptasensors given that the tunable size and shape, optical properties, surface properties, switchable modules, ease of labeling, and catalytic activities of RNA nanoparticles can be useful not only for signal generation but also for signal amplification. For more detailed information on RNA based in vitro diagnostics, readers are encouraged to refer to articles referenced in this review. − …”

Section: Applications In Nanomedicine and Nanobiotechnologymentioning

confidence: 99%

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Advancement of the Emerging Field of RNA Nanotechnology

Jasinski¹,

Haque²,

et al. 2017

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The field of RNA nanotechnology has advanced rapidly during the past decade. A variety of programmable RNA nanoparticles with defined shape, size, and stoichiometry have been developed for diverse applications in nanobiotechnology. The rising popularity of RNA nanoparticles is due to a number of factors: (1) removing the concern of RNA degradation in vitro and in vivo by introducing chemical modification into nucleotides without significant alteration of the RNA property in folding and self-assembly; (2) confirming the concept that RNA displays very high thermodynamic stability and is suitable for in vivo trafficking and other applications; (3) obtaining the knowledge to tune the immunogenic properties of synthetic RNA constructs for in vivo applications; (4) increased understanding of the 4D structure and intermolecular interaction of RNA molecules; (5) developing methods to control shape, size, and stoichiometry of RNA nanoparticles; (6) increasing knowledge of regulation and processing functions of RNA in cells; (7) decreasing cost of RNA production by biological and chemical synthesis; and (8) proving the concept that RNA is a safe and specific therapeutic modality for cancer and other diseases with little or no accumulation in vital organs. Other applications of RNA nanotechnology, such as adapting them to construct 2D, 3D, and 4D structures for use in tissue engineering, biosensing, resistive biomemory, and potential computer logic gate modules, have stimulated the interest of the scientific community. This review aims to outline the current state of the art of RNA nanoparticles as programmable smart complexes and offers perspectives on the promising avenues of research in this fast-growing field.

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“…For more detailed information on RNA based in vitro diagnostics, readers are encouraged to refer to articles referenced in this review. 215 − 217 …”

Section: Applications In Nanomedicine and Nanobiotechnologymentioning

confidence: 99%

Section: Applications In Nanomedicine and Nanobiotechnologymentioning

confidence: 99%

Advancement of the Emerging Field of RNA Nanotechnology

Jasinski¹,

Haque²,

et al. 2017

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“…In this first quantitative report, Sisquella and colleagues provided a powerful application of nanotechnology to the field of drug-discovery by improving the sensitivity and accuracy of screening assays by two orders of magnitudes [28]. Recent advantages in the development and refinement of nanodiagnostic platforms for drug discovery are summarized elsewhere, and we urge interested readers to use recent papers and the references therein as a guide to in-depth coverage of the broader field [31,32]. …”

Section: Applications Of Nanotechnology To Life Sciencesmentioning

confidence: 99%

Nanomaterials—Tools, Technology and Methodology of Nanotechnology Based Biomedical Systems for Diagnostics and Therapy

Schmidt

Storsberg

2015

Biomedicines

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Nanomedicine helps to fight diseases at the cellular and molecular level by utilizing unique properties of quasi-atomic particles at a size scale ranging from 1 to 100 nm. Nanoparticles are used in therapeutic and diagnostic approaches, referred to as theranostics. The aim of this review is to illustrate the application of general principles of nanotechnology to select examples of life sciences, molecular medicine and bio-assays. Critical aspects relating to those examples are discussed.

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“…In 1987, Guo predicted that there were a large assortment of small RNA species, known as sRNAs, in cells with obscure and novel functions but have not been identified . The advancement of the field of RNA nanotechnology is a collaboration of the scientific community, and many of them contributed to a different section for the advancement of this field. ,,,,,,− ,− ,− ,,− …”

Section: Introduction: Definition Challenges and Breakthrough Of Rna ...mentioning

confidence: 99%

Thermostability, Tunability, and Tenacity of RNA as Rubbery Anionic Polymeric Materials in Nanotechnology and Nanomedicine—Specific Cancer Targeting with Undetectable Toxicity

Binzel

Burns

et al. 2021

Chem. Rev.

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RNA nanotechnology is the bottom-up self-assembly of nanometer-scale architectures, resembling LEGOs, composed mainly of RNA. The ideal building material should be (1) versatile and controllable in shape and stoichiometry, (2) spontaneously self-assemble, and (3) thermodynamically, chemically, and enzymatically stable with a long shelf life. RNA building blocks exhibit each of the above. RNA is a polynucleic acid, making it a polymer, and its negative-charge prevents nonspecific binding to negatively charged cell membranes. The thermostability makes it suitable for logic gates, resistive memory, sensor set-ups, and NEM devices. RNA can be designed and manipulated with a level of simplicity of DNA while displaying versatile structure and enzyme activity of proteins. RNA can fold into single-stranded loops or bulges to serve as mounting dovetails for intermolecular or domain interactions without external linking dowels. RNA nanoparticles display rubber- and amoeba-like properties and are stretchable and shrinkable through multiple repeats, leading to enhanced tumor targeting and fast renal excretion to reduce toxicities. It was predicted in 2014 that RNA would be the third milestone in pharmaceutical drug development. The recent approval of several RNA drugs and COVID-19 mRNA vaccines by FDA suggests that this milestone is being realized. Here, we review the unique properties of RNA nanotechnology, summarize its recent advancements, describe its distinct attributes inside or outside the body and discuss potential applications in nanotechnology, medicine, and material science.

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In-vitro nanodiagnostic platform through nanoparticles and DNA-RNA nanotechnology

Cited by 9 publications

References 29 publications

Advancement of the Emerging Field of RNA Nanotechnology

Advancement of the Emerging Field of RNA Nanotechnology

Nanomaterials—Tools, Technology and Methodology of Nanotechnology Based Biomedical Systems for Diagnostics and Therapy

Thermostability, Tunability, and Tenacity of RNA as Rubbery Anionic Polymeric Materials in Nanotechnology and Nanomedicine—Specific Cancer Targeting with Undetectable Toxicity

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