Nanomaterials—Tools, Technology and Methodology of Nanotechnology Based Biomedical Systems for  Diagnostics and Therapy

Schmidt, Christian; Storsberg, Joachim

doi:10.3390/biomedicines3030203

Cited by 20 publications

(15 citation statements)

References 98 publications

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“…The sensitivity of γ to either conformational changes as a result of modification of the molecule itself (Irani et al, 2015;Storsberg and Schmidt, 2015;Liu and May, 2012), or as a result of recognition of the cognate antigen (Rosen et al, 2005;Stanfield et al, 2004;Saphire et al, 2001) highlights an area of biomedical sciences that is not fully understood. Consequently, any efforts in providing a universal strategy for modification of a given Ig molecule must be accompanied by a lengthy and expensive iterative process to eliminate modification schemes that would spoil its activity until systematic studies involving structural and functional interrogation were to yield guides to aid colleagues to embark in a more efficient and less costly derivatization of antibodies.…”

Section: Resultsmentioning

confidence: 99%

Functionalization Strategies for Antibodies: Lessons Learned

Schmidt¹,

Geyer²,

Bohrisch³

et al. 2017

American Journal of Immunology

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Abstract:Precious little is known about useful functionalization strategies of antibodies that will not impair either reactivity or specificity of this valuable reagent. We used an experimental approach to demonstrate our own experience with published protocols. The conjugates obtained were then tested with regard to their performance against commercially available detection kits. Our results are then viewed in light of published precedence to highlight areas where future effort is needed to refine such versatile tools.

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Section: Resultsmentioning

confidence: 99%

Functionalization Strategies for Antibodies: Lessons Learned

Schmidt¹,

Geyer²,

Bohrisch³

et al. 2017

American Journal of Immunology

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“…Moreover, it is hoped that use of nanotechnology will enhance the diversity and scope of biomedical diagnostic applications. [10][11][12] POC diagnostic assays are generally performed on a small chip usually made of silicon, paper, glass or polymer materials having micrometer scale channels.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle-based Point of Care Immunoassays for in vitro Biomedical Diagnostics

2018

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In resource-limited settings, the availability of medical practitioners and early diagnostic facilities are inadequate relative to the population size and disease burden. To address cost and delayed time issues in diagnostics, strip-based immunoassays, e.g. dipstick, lateral flow assay (LFA) and microfluidic paper-based analytical devices (microPADs), have emerged as promising alternatives to conventional diagnostic approaches. These assays rely on chromogenic agents to detect disease biomarkers. However, limited specificity and sensitivity have motivated scientists to improve the efficiency of these assays by conjugating chromogenic agents with nanoparticles for enhanced qualitative and quantitative output. Various nanomaterials, which include metallic, magnetic and luminescent nanoparticles, are being used in the fabrication of biosensors to detect and quantify biomolecules and disease biomarkers. This review discusses some of the principles and applications of such nanoparticle-based point of care biosensors in biomedical diagnosis.

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“…Nanotechnology is defined as a discipline aimed at understanding the properties and application of structures, devices, and systems where the dimensions are less than 100 nm [1,2]. Nanotechnology in medicine can be used for the production of devices, structures, and materials with a positive effect on human health.…”

Section: Introductionmentioning

confidence: 99%

Nanotubular oxide layers formed on the Ti-based implants surfaces-application and possible damages: a review

et al. 2018

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Implant surface properties define the interaction of the implant with the surrounding tissue. To obtained advanced biological, mechanical and physical properties, metallic implants are often exposed to different kinds of surface modification. The electrochemical anodization process is an efficient method for nanostructured surface modification, which leads to the formation of nanotubular oxide layers on metallic surfaces. These obtained layers could be applied in biomedicine due to their chemical stability, biocompatibility and non-toxic nature in the human body. As a part of different kinds of medical implants such as dental implants, artificial hip joints, bone plates, screws, spinal fixation devices or stents, an oxide layer significantly increases cells adhesion and plays a significant role in improving the rate of osseointegration. However, an important topic in research of implants with a nanotubular oxide layer is integrity during fixation and exploitation and possible damage initiation and development. This review article aims to present the application of nanotubular oxide layers in biomedicine and to explain their influence on the biocompatibility and osseointegration of medical implants. Influence of the layers properties, such as roughness or contact angle, and the influence of their morphology on biocompatibility and osseointegration, as well as the influence of fixation and exploitation on the damage of the nanotubular oxide layer, are considered.

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Nanomaterials—Tools, Technology and Methodology of Nanotechnology Based Biomedical Systems for Diagnostics and Therapy

Cited by 20 publications

References 98 publications

Functionalization Strategies for Antibodies: Lessons Learned

Functionalization Strategies for Antibodies: Lessons Learned

Nanoparticle-based Point of Care Immunoassays for in vitro Biomedical Diagnostics

Nanotubular oxide layers formed on the Ti-based implants surfaces-application and possible damages: a review

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