In vitro Mutagen binding and antimutagenic activity of human Lactobacillus rhamnosus 231

Potential of probiotics, prebiotics and synbiotics for management of colorectal cancer

“…62 Further, this strain exhibited in vitro binding of MNNG and MeIQx and biotransformation; and subsequent detoxification and AMA. 63 Administration of viable Lr 231 protected rats from MNNG-induced colon inflammation. 64 Levels of azoreductase, nitroreductase activities in the feces were reduced.…”

Protective effect ofLactobacillus rhamnosus231 against N-Methyl-N′-nitro-N-nitrosoguanidine in animal model

“…Previous studies reported that in vitro binding of MNNG of Lr 231 led to biotransformation and subsequent detoxification. 15 Protection received by Lr 231 could be mainly due to against MNNG induced carcinoma; and suggests that addition of these in the diet will facilitate prevention against cancer. Additionally, determination of immunomodulatory properties of Lr 231 that help in preventing inflammatory lesion development by mutagen is required.…”

“…14 L. rhamnosus 231 (Lr 231) exhibits in vitro binding of MNNG resulting in biotransformation and detoxification. 15 The present study determines the protective effect of Lr 231 against MNNG in rat model.…”

Insight into the Draft Genome Sequence of Human Isolate Lactobacillus rhamnosus LR231, a Bacterium with Probiotic Potential

“…The organism carries 66 coding sequences related to proteins and enzymes involved in ABC transporters, 7 CDSs coding for antibacterial peptides, and 6 β-lactamases, which thus confirm its broad range of antimicrobial activity and antibiotic resistance properties. Further, this strain exhibits in vitro binding of N -methyl- N ′-nitro- N -nitrosoguanidine (MNNG) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and biotransformation, as well as subsequent detoxification and antimutagenic activity (10). Administration of viable LR231 protected rats from MNNG-induced colon inflammation (11).…”