Potential of probiotics, prebiotics and synbiotics for management of colorectal cancer

Raman, Maya; Ambalam, Padma; Kondepudi, Kanthi Kiran; Pithva, Sheetal; Kothari, Charmy; Patel, Arti T.; Purama, Ravi Kiran; Dave, J. M.; Vyas, B. R. M.

doi:10.4161/gmic.23919

Cited by 213 publications

(133 citation statements)

References 137 publications

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“…Cell proliferation, which is the most important hallmarks of cancer, is the leading lethal factors for malignant cancer, especially for CRC (Gao et al, 2013;Raman et al, 2013). However, the relationship between CRC and the expression of miR- 454 has not yet been elucidated.…”

Section: Introductionmentioning

confidence: 99%

MiR-454 Prompts Cell Proliferation of Human Colorectal Cancer Cells by Repressing CYLD Expression

Liu¹,

Hu²,

Li³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Section: Introductionmentioning

confidence: 99%

MiR-454 Prompts Cell Proliferation of Human Colorectal Cancer Cells by Repressing CYLD Expression

Liu¹,

Hu²,

Li³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Moreover, the relative abundance of the Lactobacillales order was decreased in colitic Il10 −/− and in AOM/Il10 −/− mice, and in both cases, dietary curcumin restored this order to control levels. Lactobacillus strains have been used successfully in the CRC prevention in animal models [51][52][53][54] , have been shown to exhibit significant antigenotoxicity 55 , and the Lactobacillus genus was shown to be associated with cell cycle arrest and induction of apoptosis in colon cancer cell lines 5657 . Although the results of systematic and wellcontrolled clinical studies in CRC prevention are not yet available, published reports suggest cautious optimism.…”

Section: Discussionmentioning

confidence: 99%

275 The Role of Curcumin in Modulating Colonic Microbiota During Colitis and Colon Cancer Prevention

McFadden¹,

Larmonier²,

Midura-Kiela³

et al. 2014

Gastroenterology

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Background-Intestinal microbiota influences the progression of colitis-associated colorectal cancer (CAC). With diet being a key determinant of the gut microbial ecology, dietary interventions are an attractive avenue for the prevention of CAC. Curcumin is the most active constituent of the ground rhizome of the Curcuma Longa plant, which has been demonstrated to have anti-inflammatory, anti-oxidative and anti-proliferative properties.

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“…Probiotics reduce the formation of secondary bile acids by physically binding to primary bile acids and other carcinogens 61 and prebiotics 70 on the other hand maintain gut microbiota and SCFAs liberated reduce the DNA damage by lowering the luminal pH, altering DNA-methylation and enhancing apoptosis to eliminate DNA damaged cells thus contributing towards CRC management. 71 A recent study also demonstrated that consumption of probiotic yogurt for 6 weeks resulted in reduced feacal water genotoxicity agent in HT29clone 19A. 72 Probiotics also contribute towards folate production which plays a major role in DNA methylation and aids against DNA damage.…”

Section: Scanning Electron Microscopymentioning

confidence: 99%

Gum odina: an emerging gut modulating approach in colorectal cancer prevention

et al. 2017

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It is well established that prebiotics have a profound influence on colonic microbiota which in turn play an essential role in ameliorating the host's health. This study is focused on Gum Odina (GO), a reported prebiotic in our earlier work, and its impact on colorectal cancer (CRC). GO, upon utilization by probiotics, liberates short-chain fatty acids, acetic acid (0.864 AE 0.050 mg ml À1 ) and butyric acid (2.303 AE 0.083 mg ml À1) predominantly and increases colonization of Lactobacillus sp. and Bifidobacterium sp.in a gut simulator. The in vivo preventive study of CRC was conducted on Swiss albino mice using 1,2-dimethyl hydrazine (DMH) along with inulin and GO as the standard and test prebiotic, respectively.Scanning electron micrographs of the colon depict that the severity of mucosal dysplasia, flat lesions and loss of goblet cells was quite low in the GO group compared to the DMH alone treated group. The same was noticed in the histomicrograph in terms of alteration of the colonic architecture and abnormalities in the submucosa. Administration of DMH also caused oxidative burst as the levels of reactive oxygen species and lipid peroxidation significantly increased (p < 0.05) but reduced by 29.35% and 27.65%, respectively, in the GO group. Moreover, the levels of glutathione, glutathione-S-transferase, superoxide dismutase and catalase in the colonic tissues significantly increased (p < 0.05) by 31.26%, 10.96%, 12.4% and 6.37%, respectively, when compared to IN, a standard prebiotic. Thus, GO possesses CRCpreventing along with antioxidant properties and slows the overall tumor genesis process.

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Potential of probiotics, prebiotics and synbiotics for management of colorectal cancer

Cited by 213 publications

References 137 publications

MiR-454 Prompts Cell Proliferation of Human Colorectal Cancer Cells by Repressing CYLD Expression

MiR-454 Prompts Cell Proliferation of Human Colorectal Cancer Cells by Repressing CYLD Expression

275 The Role of Curcumin in Modulating Colonic Microbiota During Colitis and Colon Cancer Prevention

Gum odina: an emerging gut modulating approach in colorectal cancer prevention

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