In vitro modulation of heavy metal-induced rat liver mitochondria dysfunction: A comparison of copper and mercury with cadmium

Interactions of copper and thermal stress on mitochondrial bioenergetics in rainbow trout, Oncorhynchus mykiss

“…Because we did not observe inhibition of maximal respiration at 25 • C as would be expected at unfavorably high temperature (Zukiene et al, 2010;Guderley, 2011;Iftikar and Hickey, 2013;Blier et al, 2014) we concluded that under the experimental conditions employed, this temperature level alone did not constitute sufficient stress to impair mtCI-driven respiration in rainbow trout liver isolated mitochondria. Copper exposure on the other hand inhibited the maximal respiration in agreement with previous studies in rats (Saris and Skulskii, 1991;Belyaeva et al, 2004Belyaeva et al, , 2011, rainbow trout (Sappal et al, 2014) and bivalves (Collins et al, 2010;Ivanina and Sokolova, 2013). The inhibition of maximal respiration was consistently greater at higher temperature and interestingly, lower Cu concentrations caused greater inhibition at 5 • C compared with the putative control (15 • C).…”

“…Because the mitochondria are the primary sites of ROS generation in cells (Chen et al, 2003;Kowaltowski et al, 2009;Murphy, 2009), it is feasible that Cu can increase mitochondrial ROS generation and exacerbate damage to these organelles. Indeed, several studies have shown that mitochondria are sensitive Cu targets in endotherms and ectotherms (Saris and Skulskii, 1991;Sokol et al, 1993;Belyaeva et al, 2011;Sappal et al, 2014) with a key effect being impairment of oxidative phosphorylation (OXPHOS).…”

Liver and Cadmium Toxicity

“…Several evidences prove that mitochondria can play as key target in Cd exposure [61][62][63], and a major source of Cd-induced ROS production, mainly blocking the mitochondrial electron transport chain [64] and by uncoupling oxidative phosphorylation by the acceleration of H + influx through the Pi/H + symporter. This organelle exerts an important role in cellular energy production, and the interference with the normal oxidative metabolism induced by Cd, results in energetic deficits affecting crucial cell functions.…”

Total Mercury Determination in Muscle and Liver Tissue Samples from Brazilian Amazon Fish Using Slurry Sampling

“…The problems that living beings experience due to mercury exposure are discussed in several papers [7][8][9][10][11]. "This toxic element, mainly in organic form, may accumulate in tissues and organs of aquatic organisms in concentrations higher than those found in water.…”