In vitro modulation of glucagon-like peptide release by DPP-IV inhibitory polyphenol-polysaccharide conjugates of sprouted quinoa yoghurt

Quinoa Reduces High-Fat Diet-Induced Obesity in Mice via Potential Microbiota-Gut-Brain-Liver Interaction Mechanisms

“…In our study, quinoa could enable the lowly expressed GLP-1 in HFD group to revert. It has been established that polyphenol-polysaccharide conjugates from quinoa have great potential to stimulate GLP-1 release ( 31 ). Meanwhile, this study showed that quinoa with saponin appeared to work better on downregulation of the abundance of Firmicutes and Bacteroidetes and upregulation the abundance of Akkermansia than quinoa without saponin.…”

Effects of Different Dietary Flavonoids on Dipeptidyl Peptidase-IV Activity and Expression: Insights into Structure–Activity Relationship

“…Type 2 diabetes mellitus (T2DM) has gradually developed into a serious global disease with a tremendous burden to human health. , The International Diabetes Federation predicted that the number of patients with diabetes worldwide will increase to 642 million in 2040 . Some of the medical therapeutic strategies toward T2DM include lowering postprandial blood sugar (α-glucosidase inhibitor), enhancing insulin signaling (insulin sensitizer), and increasing insulin secretion. − Among these strategies, dipeptidyl peptidase-IV (DPP-IV) inhibitor increases insulin secretion and has drawn wide attention as a new treatment strategy for T2DM. , DPP-IV is widely distributed in human tissues and effectively degrades two crucial glucose-regulating hormones, namely, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), and those two hormones can stimulate insulin secretion to lower blood glucose . Therefore, DPP-IV inhibition could protect these two hormones (GLP-1 and GIP) against degradation. , Some synthetic compounds, such as sitagliptin and vildagliptin, have been clinically employed as DPP-IV inhibitors, but their applications are often limited by their serious side effects. , …”

Sub‐chronic consumption of a phenolic‐rich avocado paste extract induces GLP‐1‐, leptin‐, and adiponectin‐mediated satiety in Wistar rats

“…The role of phytochemicals like PCs appears to be important to a meal's action on GLP‐1, since GLP‐1‐mediated satiety (in addition to other hormones) is higher in response to a vegetable‐based meal, as compared to an isocaloric, macronutrient‐matched processed meat one in men (Klementova et al., 2019). Phenolic‐polysaccharide conjugates have been shown to stimulate GLP‐1 protein and mRNA expression, in addition to a possible increase in its half‐life in circulation by inhibiting dipeptidyl peptidase IV (DPP‐IV), the main enzyme responsible for its inactivation (Obaroakpo et al., 2020). According to our data and the literature, sub‐chronic consumption of avocado byproduct‐derived PCs may have induced sub‐chronic satiety, through a mechanism of action related in part to GLP‐1 stimulation, at both the protein and mRNA level, with no apparent involvement of CCK under the timeframes considered.…”