In vitro modeling of liver fibrosis in 3D microtissues using scalable micropatterning system

Zahmatkesh, Ensieh; Othman, Amnah; Braun, Bianca; Aspera, Romina; Ruoß, Marc; Piryaei, Abbas; Vosough, Massoud; Nüssler, Andreas K.

doi:10.1007/s00204-022-03265-7

Cited by 5 publications

(3 citation statements)

References 57 publications

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“…71 Whereas for a drug that induces fibrosis, co-cultures that include stellate cells should be considered. [72][73][74][75][76] 2D in vitro liver models mainly consist of one layer of hepatocytes, optionally in co-culture with one of the aforementioned cells (stellate cells, Kupffer cells and LSEC) seeded on the bottom of a well plate which is sometimes coated with a bioactive layer. Frequently used are extracellular matrix components such as Fibronectin and collagen.…”

Section: Reviewmentioning

confidence: 99%

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The native liver as inspiration to create superior in vitro hepatic models

et al. 2023

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Section: Reviewmentioning

confidence: 99%

“…71 Whereas for a drug that induces fibrosis, co-cultures that include stellate cells should be considered. 72–76…”

Section: Introductionmentioning

confidence: 99%

The native liver as inspiration to create superior in vitro hepatic models

et al. 2023

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“…Primary HSCs originating from normal liver tissue are used as a model for the screening of pro-and antifibrosis compounds and represent a significant reflection of in vivo liver fibrosis [13,15]. Moreover, HSCs are the cell type leading to scar formation in almost all types of liver injuries [16,17].…”

Section: In Vitro Models Of Liver Fibrosismentioning

confidence: 99%

Preclinical Models and Promising Pharmacotherapeutic Strategies in Liver Fibrosis: An Update

Kolaric,

Kuna,

Covic

et al. 2023

CIMB

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Liver fibrosis represents one of the greatest challenges in medicine. The fact that it develops with the progression of numerous diseases with high prevalence (NAFLD, viral hepatitis, etc.) makes liver fibrosis an even greater global health problem. Accordingly, it has received much attention from numerous researchers who have developed various in vitro and in vivo models to better understand the mechanisms underlying fibrosis development. All these efforts led to the discovery of numerous agents with antifibrotic properties, with hepatic stellate cells and the extracellular matrix at the center of these pharmacotherapeutic strategies. This review focuses on the current data on numerous in vivo and in vitro models of liver fibrosis and on various pharmacotherapeutic targets in the treatment of liver fibrosis.

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A comprehensive review on 3D tissue models: Biofabrication technologies and preclinical applications

Xie,

Pal,

et al. 2024

Biomaterials

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In vitro modeling of liver fibrosis in 3D microtissues using scalable micropatterning system

Cited by 5 publications

References 57 publications

The native liver as inspiration to create superior in vitro hepatic models

The native liver as inspiration to create superior in vitro hepatic models

Preclinical Models and Promising Pharmacotherapeutic Strategies in Liver Fibrosis: An Update

A comprehensive review on 3D tissue models: Biofabrication technologies and preclinical applications

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